362-03-002 ISMRM Abstract

Linking Glymphatic Clearance Function to Peripheral Inflammation in Stable Schizophrenia

Primary: Brain Function and fMRI - fMRI Analysis

Secondary: Neuro - Psychiatric Disorders

362-03-002 · Neuroimaging Signatures Across the Psychiatric Spectrum · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row C

Keywords: fMRI (resting state) Schizophrenia Cerebrospinal fluid flow Glymphatic system function Inflammatory and Immune-related Markers

Accepted

Chengmin Yang ¹, Huilou Liang², wei cui², Su Lui¹

¹West China Hospital of Sichuan University, Chendu, China

²GE HealthCare MR Research, Beijing, China

Presenting Author: Chengmin Yang

Synopsis

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References

1. Nedergaard M, Goldman SA. Glymphatic failure as a final common pathway to dementia. Science (New York, NY). 2020;370(6512):50-6.

2. Hua L, Zeng X, Zhang K, Zhao Z, Yuan Z. Reduced glymphatic clearance in early psychosis. Molecular psychiatry. 2025;30(10):4665-76.

3. Fultz NE, Bonmassar G, Setsompop K, Stickgold RA, Rosen BR, Polimeni JR, et al. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science (New York, NY). 2019;366(6465):628-31.

4. Schwartz M, Shechter R. Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease. Molecular psychiatry. 2010;15(4):342-54.

5. Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. The Lancet Neurology. 2018;17(11):1016-24.

6. Vieira É LM, Caramelli P, Rocha NP, Freitas Cardoso MDG, de Miranda AS, Teixeira AL, et al. Tumor necrosis factor superfamily molecules are increased in behavioral variant frontotemporal dementia and correlate with cortical atrophy: An exploratory investigation. Journal of neuroimmunology. 2021;354:577531.

7. Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, et al. Aquaporin-4-dependent glymphatic solute transport in the rodent brain. eLife. 2018;7.

8. Zhao F, Li B, Yang W, Ge T, Cui R. Brain-immune interaction mechanisms: Implications for cognitive dysfunction in psychiatric disorders. Cell proliferation. 2022;55(10):e13295.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/362-03-002