Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
452-01-010 / 452-01-010 ISMRM Abstract

Neurometabolite and immune alterations in children with perinatal HIV exposure: associations with language outcomes

Primary: Neuro - Infectious Disease
Secondary: Pediatrics - Neuro
452-01-010 · Pediatric Imaging Frontiers · Tuesday, 12 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2
452-01-010 · Pediatric Imaging Frontiers · Tuesday, 12 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2
Keywords: Neuroinflammation Spectroscopy HIV exposure Maternal immune activation Pediatric Brain Imaging
Accepted
Cesc Bertran Cobo 1, Frances C Robertson1,2, Simone R Williams1,3, Tusekile Sarah Kangwa1, Jenna Annandale1, Jessica E Ringshaw1,3, Layla Bradford1,3, Nadia Hoffman1, Heather Zar1,3, Dan Stein1, Kirsten A Donald1, Petrus Naudé1, Catherine Wedderburn1,3
1University of Cape Town, Cape Town, South Africa
2Cape Universities Body Imaging Centre (CUBIC), Cape Town, South Africa
3Red Cross War Memorial Children’s Hospital, Cape Town, South Africa
Presenting Author: Cesc Bertran Cobo

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References

1. Wedderburn CJ, Weldon E, Bertran-Cobo C, Rehman AM, Stein DJ, Gibb DM, et al. Early neurodevelopment of HIV-exposed uninfected children in the era of antiretroviral therapy: a systematic review and meta-analysis. Lancet Child Adolesc Health (2022) 6(6):393–408. doi:10.1016/S2352-4642(22)00071-2 [doi]
2. Han VX, Patel S, Jones HF, Dale RC. Maternal immune activation and neuroinflammation in human neurodevelopmental disorders. Nat Rev Neurol (2021) 17(9):564-579. doi:10.1038/s41582-021-00530-8. [doi]
3. Sevenoaks T, Wedderburn CJ, Donald KA, Barnett W, Zar HJ, Stein DJ, et al. Association of maternal and infant inflammation with neurodevelopment in HIV-exposed uninfected children in a South African birth cohort. Brain Behav Immun (2021) 91:65–73. doi:10.1016/j.bbi.2020.08.021 [doi]
4. Bertran-Cobo C, Robertson F, Kangwa T, Annandale J, Subramoney S, Narr K, et al. Maternal and child immune profiles are associated with neurometabolite measures of early-life neuroinflammation in children who are HIV-exposed and uninfected: a South African birth cohort. Res Sq [Preprint] (2025) 21:rs.3.rs-6169072. doi:10.21203/rs.3.rs-6169072/v2. [doi]
5. Zar HJ, Barnett W, Myer L, Stein DJ, Nicol MP. Investigating the Early-Life Determinants of Illness in Africa: The Drakenstein Child Health Study. Thorax (2015) 70(6):592–4. doi: 10.1136/thoraxjnl-2014-206242 [doi]
6. Stein DJ, Koen N, Donald KA, Adnams CM, Koopowitz S, Lund C, et al. Investigating the Psychosocial Determinants of Child Health in Africa: The Drakenstein Child Health Study. J Neurosci Methods (2015) 252:27–35. doi:10.1016/j.jneumeth.2015.03.016 [doi]
7. Donald KA, Hoogenhout M, du Plooy CP, Wedderburn CJ, Nhapi RT, Barnett W, et al. Drakenstein Child Health Study (DCHS): Investigating Determinants of Early Child Development and Cognition. BMJ Paediatr Open (2018) 2(1):e000282. doi:10.1136/bmjpo-2018-000282 [doi]
8. Williams SR, Robertson FC, Wedderburn CJ, Ringshaw JE, Bradford L, Nyakonda CN, et al. 1H-MRS neurometabolite profiles and motor development in school-aged children who are HIV-exposed uninfected: a birth cohort study. Front Neurosci (2023) 12;17:1251575. doi:10.3389/fnins.2023.1251575. [doi]
9. Provencher SW. Automatic Quantitation of Localized In Vivo 1H Spectra With LCModel. NMR Biomed (2001) 14(4):260–4. doi:10.1002/nbm.698 [doi]
10. Snelling M, Dawes A, Biersteker L, Girdwood E, Tredoux C. The development of a South African Early Learning Outcomes Measure: A South African instrument for measuring early learning program outcomes. Child Care Health Dev (2019) 45(2):257-270. doi:10.1111/cch.12641. [doi]
11. Sánchez SM, Schmidt H, Gallardo G, Anwander A, Brauer J, Friederici AD, et al. White matter brain structure predicts language performance and learning success. Hum Brain Mapp (2023) 44(4):1445-1455. doi:10.1002/hbm.26132. [doi]
12. Wedderburn CJ, Evans C, Yeung S, Gibb DM, Donald KA, Prendergast AJ. Growth and Neurodevelopment of HIV-Exposed Uninfected Children: a Conceptual Framework. Curr HIV/AIDS Rep (2019) 16(6):501-513. doi:10.1007/s11904-019-00459-0. [doi]

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http://echo.ismrm.org/p/ISMRM2026/452-01-010