Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
403-01-008 ISMRM Abstract

High‑Resolution Diffusion Tractography Shows Altered Superficial White Matter in Multiple Sclerosis Across the Lifespan

Primary: Diffusion - Tractography
Secondary: Diffusion - DWI/DTI/DKI
403-01-008 · Diffusion Tractography · Tuesday, 12 May, 8:20 AM–10:10 AM · Auditorium 1
Keywords: Multiple Sclerosis Lifespan Superficial White Matter Normal-Appearing White Matter Constrained spherical deconvolution tractography
Accepted
Alejandro Acosta 1, Javier Urbina-Alarcón1, Adithi Madireddy2, Zhongyi Sun1, Carly Weber1, Penelope Smyth3, Gregg Blevins3, Colin Wilbur4, Nabeela Nathoo3, Derek Emery2, Christian Beaulieu1,2
1Biomedical Engineering, University of Alberta, Edmonton, Canada
2Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Canada
3Neurology, University of Alberta, Edmonton, Canada
4Pediatric Neurology, University of Alberta, Edmonton, Canada
Presenting Author: Alejandro Acosta

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Phillips, O. R., Joshi, S. H., Squitieri, F., Sanchez-Castaneda, C., Narr, K., Shattuck, D. W., Caltagirone, C., Sabatini, U., & Di Paola, M. (2016). Major Superficial White Matter Abnormalities in Huntington's Disease. Frontiers in neuroscience, 10, 197. https://doi.org/10.3389/fnins.2016.00197 [doi]
2. Guevara, M., Guevara, P., Román, C., & Mangin, J. F. (2020). Superficial white matter: A review on the dMRI analysis methods and applications. NeuroImage, 212, 116673. https://doi.org/10.1016/j.neuroimage.2020.116673 [doi]
3. Van Dyken, P. C., Khan, A. R., & Palaniyappan, L. (2024). Imaging of the superficial white matter in health and disease. Imaging neuroscience (Cambridge, Mass.), 2, imag-2-00221. https://doi.org/10.1162/imag_a_00221 [doi]
4. Schilling, K., Zhang, F., Román, C., O'Donnell, L. J., & Guevara, P. (2025). Short association fiber tractography: key insights and surprising facts. Brain structure & function, 230(6), 97. https://doi.org/10.1007/s00429-025-02966-w [doi]
5. Granziera, C., Wuerfel, J., Barkhof, F., Calabrese, M., De Stefano, N., Enzinger, C., Evangelou, N., Filippi, M., Geurts, J. J. G., Reich, D. S., Rocca, M. A., Ropele, S., Rovira, À., Sati, P., Toosy, A. T., Vrenken, H., Gandini Wheeler-Kingshott, C. A. M., Kappos, L., & MAGNIMS Study Group (2021). Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis. Brain : a journal of neurology, 144(5), 1296–1311. https://doi.org/10.1093/brain/awab029 [doi]
6. Buyukturkoglu, K., Vergara, C., Fuentealba, V., Tozlu, C., Dahan, J. B., Carroll, B. E., Kuceyeski, A., Riley, C. S., Sumowski, J. F., Oliva, C. G., Sitaram, R., Guevara, P., & Leavitt, V. M. (2022). Machine learning to investigate superficial white matter integrity in early multiple sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 32(1), 36–47. https://doi.org/10.1111/jon.12934 [doi]
7. Komnenić, D., Phillips, O. R., Joshi, S. H., Chien, C., Schmitz-Hübsch, T., Asseyer, S., Paul, F., & Finke, C. (2024). Superficial white matter integrity in neuromyelitis optica spectrum disorder and multiple sclerosis. Multiple sclerosis journal - experimental, translational and clinical, 10(1), 20552173231226107. https://doi.org/10.1177/20552173231226107 [doi]
8. Luo, D., Peng, Y., Zhu, Q., Zheng, Q., Luo, Q., Han, Y., Chen, X., & Li, Y. (2024). U-fiber diffusion kurtosis and susceptibility characteristics in relapsing-remitting multiple sclerosis may be related to cognitive deficits and neurodegeneration. European radiology, 34(3), 1422–1433. https://doi.org/10.1007/s00330-023-10114-3 [doi]
9. Schilling, K. G., Archer, D., Rheault, F., Lyu, I., Huo, Y., Cai, L. Y., Bunge, S. A., Weiner, K. S., Gore, J. C., Anderson, A. W., & Landman, B. A. (2023). Superficial white matter across development, young adulthood, and aging: volume, thickness, and relationship with cortical features. Brain structure & function, 228(3-4), 1019–1031. https://doi.org/10.1007/s00429-023-02642-x [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/403-01-008