Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
651-01-002 / 651-01-002 ISMRM Abstract

The Value of DKI and APTw for Preoperative Evaluation of Microsatellite Instability in Endometrial Adenocarcinoma

Primary: Body - Uterus
Secondary: Diffusion - DWI/DTI/DKI
651-01-002 · Pelvic MRI: Bladder, Endometrium, and Rectum · Thursday, 14 May, 8:30 AM–10:06 AM · Power Pitch Theatre 1
651-01-002 · Pelvic MRI: Bladder, Endometrium, and Rectum · Thursday, 14 May, 8:30 AM–10:06 AM · Power Pitch Theatre 1
Keywords: Microsatellite instability Diffusion kurtosis imaging Endometrial Adenocarcinoma Amide proton transfer-weighted imaging
Accepted
Lingyu Chang 1,2, Xiukai Zhao3, Lianhua Cheng1, Pu-Yeh Wu4, Xinghua Xu1, Liang Du2, Xiangshui Meng2, Fang Wang1
1Qilu Hospital of Shandong University, Jinan, China
2Qilu Hospital (Qingdao) of Shandong University, Shandong province, China
3Qingdao Third People's Hospital, China
4GE Healthcare, Beijing, China
Presenting Author: Lingyu Chang

Synopsis

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References

1. Wu X, Snir O, Rottmann D, Wong S, Buza N, Hui P. Minimal microsatellite shift in microsatellite instability high endometrial cancer: a significant pitfall in diagnostic interpretation. Mod Pathol. 2019 May;32(5):650-658. doi: 10.1038/s41379-018-0179-3. Epub 2018 Nov 15. PMID: 30443012. [doi] [pmid]
2. Rousset-Rouviere S, Rochigneux P, Chrétien AS, Fattori S, Gorvel L, Provansal M, Lambaudie E, Olive D, Sabatier R. Endometrial Carcinoma: Immune Microenvironment and Emerging Treatments in Immuno-Oncology. Biomedicines. 2021 Jun 2;9(6):632. doi: 10.3390/biomedicines9060632. PMID: 34199461; PMCID: PMC8228955. [doi] [pmid]
3. Ray KJ, Simard MA, Larkin JR, Coates J, Kinchesh P, Smart SC, Higgins GS, Chappell MA, Sibson NR. Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging. Cancer Res. 2019 Apr 1;79(7):1343-1352. doi: 10.1158/0008-5472.CAN-18-2168. Epub 2019 Jan 24. PMID: 30679178; PMCID: PMC6462213. [doi] [pmid]
4. Jensen JH, Helpern JA, Ramani A, Lu H, Kaczynski K. Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med. 2005 Jun;53(6):1432-40. doi: 10.1002/mrm.20508. PMID: 15906300. [doi] [pmid]
5. Lin Y, Luo X, Yu L, Zhang Y, Zhou J, Jiang Y, Zhang C, Zhang J, Li C, Chen M. Amide proton transfer-weighted MRI for predicting histological grade of hepatocellular carcinoma: comparison with diffusion-weighted imaging. Quant Imaging Med Surg. 2019 Oct;9(10):1641-1651. doi: 10.21037/qims.2019.08.07. PMID: 31728308; PMCID: PMC6828579. [doi] [pmid]
6. Ray KJ, Simard MA, Larkin JR, Coates J, Kinchesh P, Smart SC, Higgins GS, Chappell MA, Sibson NR. Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging. Cancer Res. 2019 Apr 1;79(7):1343-1352. doi: 10.1158/0008-5472.CAN-18-2168. Epub 2019 Jan 24. PMID: 30679178; PMCID: PMC6462213. [doi] [pmid]
7. Howitt BE, Shukla SA, Sholl LM, Ritterhouse LL, Watkins JC, Rodig S, Stover E, Strickland KC, D'Andrea AD, Wu CJ, Matulonis UA, Konstantinopoulos PA. Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1. JAMA Oncol. 2015 Dec;1(9):1319-23. doi: 10.1001/jamaoncol.2015.2151. PMID: 26181000. [doi] [pmid]
8. Akhtar M, Al Hyassat S, Elaiwy O, Rashid S, Al-Nabet ADMH. Classification of Endometrial Carcinoma: New Perspectives Beyond Morphology. Adv Anat Pathol. 2019 Nov;26(6):421-427. doi: 10.1097/PAP.0000000000000251. PMID: 31567131. [doi] [pmid]
9. Addante F, d'Amati A, Santoro A, Angelico G, Inzani F, Arciuolo D, Travaglino A, Raffone A, D'Alessandris N, Scaglione G, Valente M, Tinnirello G, Sfregola S, Padial Urtueta B, Piermattei A, Cianfrini F, Mulè A, Bragantini E, Zannoni GF. Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications. Int J Mol Sci. 2024 Jan 15;25(2):1056. doi: 10.3390/ijms25021056. PMID: 38256131; PMCID: PMC10816607. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/651-01-002