1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada
2Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
4Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Presenting Author: Jianmei Qin
Synopsis
Motivation:
Goals:
Approach:
Results:
Full abstract & presentation
The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.
Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.
To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.
1. W. Li, H. Jiang, N. Song, and J. Xie, “Oxidative Stress Partially Contributes to Iron-Induced Alpha-Synuclein Aggregation in SK-N-SH Cells,” Neurotox. Res., vol. 19, no. 3, pp. 435–442, Apr. 2011, doi: 10.1007/s12640-010-9187-x. [doi]
2. R. J. Ward, F. A. Zucca, J. H. Duyn, R. R. Crichton, and L. Zecca, “The role of iron in brain ageing and neurodegenerative disorders,” Lancet Neurol., vol. 13, no. 10, pp. 1045–1060, Oct. 2014, doi: 10.1016/S1474-4422(14)70117-6. [doi]
3. N. Straumann et al., “Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson’s disease in vivo,” Brain Pathol., vol. 34, no. 6, p. e13288, 2024, doi: 10.1111/bpa.13288. [doi]
4. J. A. Duce, B. X. Wong, H. Durham, J.-C. Devedjian, D. P. Smith, and D. Devos, “Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease,” Mol. Neurodegener., vol. 12, no. 1, p. 45, June 2017, doi: 10.1186/s13024-017-0186-8. [doi]
5. J. Huck et al., “High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps,” Brain Struct. Funct., vol. 224, no. 7, pp. 2467–2485, Sept. 2019, doi: 10.1007/s00429-019-01919-4. [doi]
6. A. Vo et al., “Convergent large-scale network and local vulnerabilities underlie brain atrophy across Parkinson’s disease stages: a worldwide ENIGMA study”.
7. B. T. Thomas Yeo et al., “The organization of the human cerebral cortex estimated by intrinsic functional connectivity,” J. Neurophysiol., vol. 106, no. 3, pp. 1125–1165, Sept. 2011, doi: 10.1152/jn.00338.2011. [doi]
8. L. H. Scholtens, M. A. de Reus, S. C. de Lange, R. Schmidt, and M. P. van den Heuvel, “An MRI Von Economo – Koskinas atlas,” NeuroImage, vol. 170, pp. 249–256, Apr. 2018, doi: 10.1016/j.neuroimage.2016.12.069. [doi]
9. J. Y. Hansen et al., “Mapping neurotransmitter systems to the structural and functional organization of the human neocortex,” Nat. Neurosci., vol. 25, no. 11, pp. 1569–1581, Nov. 2022, doi: 10.1038/s41593-022-01186-3. [doi]
10. R. D. Markello, A. Arnatkeviciute, J.-B. Poline, B. D. Fulcher, A. Fornito, and B. Misic, “Standardizing workflows in imaging transcriptomics with the abagen toolbox,” eLife, vol. 10, p. e72129, Nov. 2021, doi: 10.7554/eLife.72129. [doi]
11. K. Wagstyl et al., “Transcriptional cartography integrates multiscale biology of the human cortex,” eLife, vol. 12, p. RP86933, Feb. 2024, doi: 10.7554/eLife.86933. [doi]
12. K. R. Maynard et al., “Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex,” Nat. Neurosci., vol. 24, no. 3, pp. 425–436, Mar. 2021, doi: 10.1038/s41593-020-00787-0. [doi]
13. Z. He et al., “Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques,” Nat. Neurosci., vol. 20, no. 6, pp. 886–895, June 2017, doi: 10.1038/nn.4548. [doi]
14. Y. Zhang et al., “Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse,” Neuron, vol. 89, no. 1, pp. 37–53, Jan. 2016, doi: 10.1016/j.neuron.2015.11.013. [doi]
15. B. B. Lake et al., “Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain,” Nat. Biotechnol., vol. 36, no. 1, pp. 70–80, Jan. 2018, doi: 10.1038/nbt.4038. [doi]
16. S. Darmanis et al., “A survey of human brain transcriptome diversity at the single cell level,” Proc. Natl. Acad. Sci., vol. 112, no. 23, pp. 7285–7290, June 2015, doi: 10.1073/pnas.1507125112. [doi]
17. M. Li et al., “Integrative functional genomic analysis of human brain development and neuropsychiatric risks,” Science, vol. 362, no. 6420, p. eaat7615, Dec. 2018, doi: 10.1126/science.aat7615. [doi]
18. E. Gómez-Tortosa, J. L. Sanders, K. Newell, and B. T. Hyman, “Cortical neurons expressing calcium binding proteins are spared in dementia with Lewy bodies,” Acta Neuropathol. (Berl.), vol. 101, no. 1, pp. 36–42, Jan. 2001, doi: 10.1007/s004010000270. [doi]