Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
566-04-013 ISMRM Abstract

Using Linked Independent Component Analysis to Identify Multimodal Biomarkers of Perinatal HIV and Early ART at age 11 years

Primary: Analysis Methods - Data Processing
Secondary: Neuro - Development
566-04-013 · Predicting Neurologic Outcomes · Wednesday, 13 May, 2:35 PM–3:30 PM · Digital Posters Row G
Keywords: Neurodevelopment Children HIV Linked Indepednent Component Analysis
Accepted
Siobhán G Stevenson 1, Joanah S Madzime2,3, Peter Torre, Barbara Laughton, Andre J van der Kouwe1,4,5,6,7,8,9, Ernesta Meintjes1,10,11,12, Frances C Robertson1,10,11,12,13,14, Isaac Khobo
1Human Biology, University of Cape Town, Cape Town, South Africa
2National Institute of Health, Bethesda, United States of America
3NIBIB, National Institute of Health, Bethesda, United States of America
4Massachusetts General Hospital, Boston, United States of America
5Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, United States of America
6Radiology, Harvard Medical School, Boston, United States of America
7Harvard Medical School, Boston, United States of America
8Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
9Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
10University of Cape Town, Cape Town, South Africa
11Neuroscience Institute, University of Cape Town, Cape Town, South Africa
12CUBIC, University of Cape Town, Cape Town, South Africa
13Cape Universities Body Imaging Centre (CUBIC), Cape Town, South Africa
14Department of Human Biology, University of Cape Town, Cape Town, South Africa
Presenting Author: Siobhán G Stevenson

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References

1. UNAIDS, “AIDSinfo | UNAIDS.” Accessed: Aug. 10, 2023. [Online]. Available: https://aidsinfo.unaids.org/
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3. B. Laughton et al., “Five year neurodevelopment outcomes of perinatally HIV-infected children on early limited or deferred continuous antiretroviral therapy,” J Int AIDS Soc, vol. 21, no. 5, p. e25106, May 2018, doi: 10.1002/JIA2.25106. [doi]
4. J. Sui et al., “Structural and Functional Brain Abnormalities in Human Immunodeficiency Virus Disease Revealed by Multimodal Magnetic Resonance Imaging Fusion: Association With Cognitive Function,” Clin Infect Dis, vol. 73, no. 7, p. e2287, Oct. 2021, doi: 10.1093/CID/CIAA1415. [doi]
5. I. L. Khobo et al., “Multimodal magnetic resonance neuroimaging measures characteristic of early cART‐treated pediatric HIV: A feature selection approach,” Hum Brain Mapp, vol. 43, no. 13, p. 4128, Sep. 2022, doi: 10.1002/HBM.25907. [doi]
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7. A. M. Dale, B. Fischl, and M. I. Sereno, “Cortical Surface-Based Analysis: I. Segmentation and Surface Reconstruction,” Neuroimage, vol. 9, no. 2, pp. 179–194, Feb. 1999, doi: 10.1006/NIMG.1998.0395. [doi]
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10. S. M. Smith et al., “Advances in functional and structural MR image analysis and implementation as FSL,” Neuroimage, vol. 23 Suppl 1, no. SUPPL. 1, 2004, doi: 10.1016/J.NEUROIMAGE.2004.07.051. [doi]

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http://echo.ismrm.org/p/ISMRM2026/566-04-013