460-02-015 Registered Abstract

Quantitative 7T Deuterium Metabolic Imaging for Assessing Glucose Metabolism in Alzheimer’s Disease

Primary: Contrast Mechanisms - Deuterium

Secondary: Neuro - Alzheimer's Disease

460-02-015 · From Bench to Bedside: All About the Brain in Health and Alzheimer’s Disease · Tuesday, 12 May, 9:15 AM–10:10 AM · Digital Posters Row A

Keywords: Alzheimer's Disease 7T Deuterium Metabolic Imaging 3D magnetic resonance spectroscopic imaging Glucose metabolism

Accepted

Masha Novoselova ^1,2, Jabrane Karkouri^1,2, Orsolya Vittay³, John O'Brien⁴, Joshua D Kaggie⁵, Tomasz Matys^3,5, James B Rowe², Chris Rodgers^1,2

¹Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom

²Department of clinical neurosciences, University of Cambridge, Cambridge, United Kingdom

³Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

⁴Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom

⁵Department of Radiology, University of Cambridge, Cambridge, United Kingdom

Presenting Author: Masha Novoselova

Synopsis

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References

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2. de Graaf, R. A., Hendriks, A. D., Klomp, D. W. J., Kumaragamage, C., Welting, D., Arteaga de Castro, C. S., Brown, P. B., McIntyre, S., Nixon, T. W., Prompers, J. J., & De Feyter, H. M. (2020). On the magnetic field dependence of deuterium metabolic imaging. NMR in biomedicine, 33(3), e4235. https://doi.org/10.1002/nbm.4235 [doi]

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4. Karkouri, J., Novoselova, M., Miller, S., Zhang, M., Constantinou, A., Graf, C., Atkinson, D., Tramm, B., Schillak, S., Mair, R., Brindle, K., Rodgers, C. T. (2025). Absolute quantification of brain deuterium metabolic imaging in healthy volunteers and glioblastoma patients at 7T. medRxiv. https://doi.org/10.1101/2025.10.08.25337571 [doi]

5. Khan, A. S., Peterson, K. A., Vittay, O. I., McLean, M. A., Kaggie, J. D., O'Brien, J. T., Rowe, J. B., Gallagher, F. A., & Matys, T. (2024). Deuterium Metabolic Imaging of Alzheimer Disease at 3-T Magnetic Field Strength: A Pilot Case-Control Study. Radiology, 312(1), e232407. https://doi.org/10.1148/radiol.232407 [doi]

6. Purvis, L. A. B., Clarke, W. T., Biasiolli, L., Valkovič, L., Robson, M. D., & Rodgers, C. T. (2017). OXSA: An open-source magnetic resonance spectroscopy analysis toolbox in MATLAB. PloS one, 12(9), e0185356. https://doi.org/10.1371/journal.pone.0185356 [doi]

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8. Chen, Y., Wang, J., Cui, C., Su, Y., Jing, D., Wu, L., Liang, P., & Liang, Z. (2021). Evaluating the association between brain atrophy, hypometabolism, and cognitive decline in Alzheimer's disease: a PET/MRI study. Aging, 13(5), 7228–7246. https://doi.org/10.18632/aging.202580 [doi]

9. Sodré, M. E., Wießner, I., Irfan, M., Schenck, C. H., & Mota-Rolim, S. A. (2023). Awake or Sleeping? Maybe Both… A Review of Sleep-Related Dissociative States. Journal of clinical medicine, 12(12), 3876. https://doi.org/10.3390/jcm12123876 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/460-02-015