Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-05-001 ISMRM Abstract

Spatially Resolved Measurements Mapping 129Xe T2-Star in Pulmonary Membrane Tissue and Red Blood Cells

Accepted
Anna Costelle 1, Suphachart Leewiwatwong2, John P Mugler3, Seth N Lee1, David Mummy1,4, Bastiaan Driehuys1,2,4
1Medical Physics Graduate Program, Duke University, Durham, United States of America
2Department of Biomedical Engineering, Duke University, Durham, United States of America
3School of Medicine, University of Virginia, Charlottesville, United States of America
4Department of Radiology, Duke University, Durham, United States of America
Presenting Author: Anna Costelle

Synopsis

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References

1. Niedbalski PJ, Hall CS, Castro M, Eddy RL, Rayment JH, Svenningsen S, Parraga G, Zanette B, Santyr GE, Thomen RP, et al. Protocols for multi-site trials using hyperpolarized (129) Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the (129) Xe MRI clinical trials consortium. Magn Reson Med. 2021;86:2966-2986. doi: 10.1002/mrm.28985 [doi]
2. Kaushik SS, Robertson SH, Freeman MS, He M, Kelly KT, Roos JE, Rackley CR, Foster WM, McAdams HP, Driehuys B. Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition. Magn Reson Med. 2016;75:1434-1443. doi: 10.1002/mrm.25675 [doi]
3. Leewiwatwong S, Bechtel A, Mummy D, Zhang S, Lu J, Costelle A, Cleveland ZI, Willmering M, Parra-Robles J, Fain S, et al. Establishing standardized healthy reference distributions and values for multisite (129)Xe gas exchange MRI/MR spectroscopy at 3 T across major scanner platforms. Magn Reson Med. 2025;94:1684-1699. doi: 10.1002/mrm.30586 [doi]
4. Xu X, Norquay G, Parnell SR, Deppe MH, Ajraoui S, Hashoian R, Marshall H, Griffiths PD, Parra-Robles J, Wild JM. Hyperpolarized 129Xe gas lung MRI-SNR and T2* comparisons at 1.5 T and 3 T. Magn Reson Med. 2012;68:1900-1904. doi: 10.1002/mrm.24190 [doi]
5. Willmering M, Matheson A, Niedbalski P, Cleveland Z, Walkup L, Woods J. Assessment of Sequence and Assumption Imperfections on 1-point Dixon 129Xe Gas Exchange MRI Metrics. In: ISMRM Annual Meeting. Honolulu, HI; 2025.
6. Mata J, Guan S, Qing K, Tustison N, Shim Y, Mugler JP, 3rd, Altes T, Huaromo J, Mehrad B. Evaluation of Regional Lung Function in Pulmonary Fibrosis with Xenon-129 MRI. Tomography. 2021;7:452-465. doi: 10.3390/tomography7030039 [doi]
7. Guan S, Tustison N, Qing K, Shim YM, Mugler J, 3rd, Altes T, Albon D, Froh D, Mehrad B, Patrie J, et al. 3D Single-Breath Chemical Shift Imaging Hyperpolarized Xe-129 MRI of Healthy, CF, IPF, and COPD Subjects. Tomography. 2022;8:2574-2587. doi: 10.3390/tomography8050215 [doi]
8. Bier EA, Robertson SH, Schrank GM, Rackley C, Mammarappallil JG, Rajagopal S, McAdams HP, Driehuys B. A protocol for quantifying cardiogenic oscillations in dynamic (129) Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis. NMR Biomed. 2019;32:e4029. doi: 10.1002/nbm.4029 [doi]
9. Haacke EM. Magnetic resonance imaging : physical principles and sequence design. J. Wiley & Sons; 1999.
10. Collier GJ, Eaden JA, Hughes PJC, Bianchi SM, Stewart NJ, Weatherley ND, Norquay G, Schulte RF, Wild JM. Dissolved (129) Xe lung MRI with four-echo 3D radial spectroscopic imaging: Quantification of regional gas transfer in idiopathic pulmonary fibrosis. Magn Reson Med. 2021;85:2622-2633. doi: 10.1002/mrm.28609 [doi]

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