Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
651-02-011 / 651-02-011 ISMRM Abstract

Dynamic Diffusion Weighted Imaging Reveals Impaired Glymphatic Cerebrospinal Fluid Dynamics in cSVD Pathogenesis

Primary: Neuro - Stroke and Cerebrovascular Disorders
Secondary: Diffusion - Diffusion Analysis & Visualization
651-02-011 · Diffusion Modeling To Map Tissue Microstructure · Thursday, 14 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
651-02-011 · Diffusion Modeling To Map Tissue Microstructure · Thursday, 14 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
Keywords: Cerebral small vessel disease Glymphatic system (GS) Perivascular spaces (PVS) Cerebrospinal fluid (CSF) dynamics Dynamic diffusion-weighted imaging
Accepted
Yurong Ma 1, Songhong Yue1, Na Han1, Mingsong Tang1,2, Yuhui Xiong3, Guangxu Han3, Yanli Jiang1, Pengfei Wang1, Jing Zhang1,2,4,5
1Department of Magnetic Resonance, Lanzhou, China
2The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China
3GE HealthCare MR Research, Beijing, China
4Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou, China, Department of Magnetic Resonance, Lanzhou, China
5Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou, China, Department of Magnetic Resonance, Lanzhou, China
Presenting Author: Yurong Ma

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References

1. [1] VAN DEN BRINK H, DOUBAL F N, DUERING M. Advanced MRI in cerebral small vessel disease [J]. Int J Stroke, 2023, 18(1): 28-35.doi: 10.1177/17474930221091879. [doi]
2. [2] TER TELGTE A, DUERING M. Cerebral Small Vessel Disease: Advancing Knowledge With Neuroimaging [J]. Stroke, 2024, 55(6): 1686-8. doi: 10.1161/STROKEAHA.123.044294. [doi]
3. [3] BLAIR G W, THRIPPLETON M J, SHI Y, et al. Intracranial hemodynamic relationships in patients with cerebral small vessel disease [J]. Neurology, 2020, 94(21): e2258-e69.doi: 10.1212/WNL.0000000000009483. [doi]
4. [4] DUERING M, BIESSELS G J, BRODTMANN A, et al. Neuroimaging standards for research into small vessel disease-advances since 2013 [J]. Lancet Neurol, 2023, 22(7): 602-18.doi: 10.1016/S1474-4422(23)00131-X. [doi]
5. [5] HAN G, JIAO B, ZHANG Y, et al. Arterial pulsation dependence of perivascular cerebrospinal fluid flow measured by dynamic diffusion tensor imaging in the human brain [J]. Neuroimage, 2024, 297: 120653.doi: 10.1016/j.neuroimage.2024.120653. [doi]
6. [6] WEN Q, WRIGHT A, TONG Y, et al. Paravascular fluid dynamics reveal arterial stiffness assessed using dynamic diffusion‐weighted imaging [J]. NMR in Biomedicine, 2023, 37(2).doi: 10.1002/nbm.5048. [doi]
7. [7] CHUANG S Y, WANG P N, CHEN L K, et al. Associations of Blood Pressure and Carotid Flow Velocity with Brain Volume and Cerebral Small Vessel Disease in a Community-Based Population [J]. Transl Stroke Res, 2021, 12(2): 248-58.doi: 10.1007/s12975-020-00836-7. [doi]
8. [8] YAMADA S, OTANI T, II S, et al. Modeling cerebrospinal fluid dynamics across the entire intracranial space through integration of four-dimensional flow and intravoxel incoherent motion magnetic resonance imaging [J]. Fluids Barriers CNS, 2024, 21(1): 47.doi: 10.1186/s12987-024-00552-6. [doi]

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http://echo.ismrm.org/p/ISMRM2026/651-02-011