362-05-010 ISMRM Abstract

Region and Cell-Type Specific Impacts of Subanesthetic Ketamine on Neurometabolic Activity in Mouse Brain

Primary: Neuro - Psychiatric Disorders

Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods

362-05-010 · Spectroscopy and Spectroscopic Imaging: Neuro II · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row C

Keywords: Glucose metabolism Depression Antidepressant Glutamate Astrocyte

Accepted

Ajay Sarawagi ¹, Sreemantula Arun Kumar¹, Anant B Patel¹

¹NMR MICROIMAGING AND SPECTROSCOPY, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India

Presenting Author: Ajay Sarawagi

Synopsis

Motivation:

Goals:

Approach:

Results:

Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

References

1. Berman, R. M. et al. Antidepressant effects of ketamine in depressed patients. Biol. Psychiatry 47, 351–354 (2000).

2. Chowdhury, G. M. I. et al. Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects. Mol. Psychiatry 22, 120–126 (2017).

3. Abdallah, C. G. et al. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology 43, 2154–2160 (2018).

4. Mishra, P. K., Kumar, A., Behar, K. L. & Patel, A. B. Subanesthetic ketamine reverses neuronal and astroglial metabolic activity deficits in a social defeat model of depression. J. Neurochem. 146, 722–734 (2018).

5. Bélanger, M., Allaman, I. & Magistretti, P. J. Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation. Cell Metab. 14, 724–738 (2011).

6. Sonnay, S. et al. Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate-glutamine cycle in the tree shrew visual cortex. Glia 66, 477–491 (2018).

7. Soni, N. D., Ramesh, A., Roy, D. & Patel, A. B. Brain energy metabolism in intracerebroventricularly administered streptozotocin mouse model of Alzheimer’s disease: A 1 H-[ 13 C]-NMR study. J. Cereb. Blood Flow Metab. 41, 2344–2355 (2021).

8. Bagga, P. et al. Characterization of Cerebral Glutamine Uptake from Blood in the Mouse Brain: Implications for Metabolic Modeling of 13 C NMR Data. J. Cereb. Blood Flow Metab. 34, 1666–1672 (2014).

9. Abdallah, C. G. et al. Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment. Biol. Psychiatry Cogn. Neurosci. Neuroimaging 2, 566–574 (2017).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/362-05-010