Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
467-05-003 ISMRM Abstract

Effect of Diffusion Time on Brain Microstructural Estimation Using Ultra-High Gradient MRI

Primary: Diffusion - Microstructure
Secondary: Physics & Engineering - Gradients
467-05-003 · Frontiers of System Design · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row H
Keywords: Human brain Microstructural Parameter Estimation Ultra High Performance Gradients OGSE Diffusion time
Accepted
Jie Lu1, Xingzhou Chen 1, Haotian Li1, Jiayu Zhu2, Jianmin Yuan2, Dan Wu1
1Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China
2Collaborative Innovation Department, United Imaging Health Care Group Co., Shanghai, China
Presenting Author: Xingzhou Chen

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Ba R, Kang L, Wu D. Time-dependent diffusion magnetic resonance imaging: measurement, modeling, and applications. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE A. 2024;25(10):765-87. doi: 10.1631/jzus.A2400139. [doi]
2. Xu J. Probing neural tissues at small scales: Recent progress of oscillating gradient spin echo (OGSE) neuroimaging in humans. Journal of Neuroscience Methods. 2021;349:109024. doi: https://doi.org/10.1016/j.jneumeth.2020.109024. [doi]
3. Novikov DS, Fieremans E, Jespersen SN, Kiselev VG. Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation. NMR in Biomedicine. 2019;32(4):e3998. doi: https://doi.org/10.1002/nbm.3998. [doi]
4. Ba R, Wang X, Zhang Z, Li Q, Sun Y, Zhang J, et al. Diffusion-time dependent diffusion MRI: effect of diffusion-time on microstructural mapping and prediction of prognostic features in breast cancer. European Radiology. 2023;33(9):6226-37. doi: 10.1007/s00330-023-09623-y. [doi]
5. Jones DK, Alexander DC, Bowtell R, Cercignani M, Dell'Acqua F, McHugh DJ, et al. Microstructural imaging of the human brain with a ‘super-scanner’: 10 key advantages of ultra-strong gradients for diffusion MRI. NeuroImage. 2018;182:8-38. doi: https://doi.org/10.1016/j.neuroimage.2018.05.047. [doi]
6. Ramos-Llordén G, Lee H-H, Davids M, Dietz P, Krug A, Kirsch JE, et al. Ultra-high gradient connectomics and microstructure MRI scanner for imaging of human brain circuits across scales. Nature Biomedical Engineering. 2025. doi: 10.1038/s41551-025-01457-x. [doi]
7. Tan ET, Shih RY, Mitra J, Sprenger T, Hua Y, Bhushan C, et al. Oscillating diffusion‐encoding with a high gradient‐amplitude and high slew‐rate head‐only gradient for human brain imaging. Magnetic Resonance in Medicine. 2020;84(2):950-65. doi: 10.1002/mrm.28180. [doi]
8. Wu D, Kang L, Li H, Ba R, Cao Z, Liu Q, et al. Developing an AI-empowered head-only ultra-high-performance gradient MRI system for high spatiotemporal neuroimaging. NeuroImage. 2024;290:120553. doi: https://doi.org/10.1016/j.neuroimage.2024.120553. [doi]
9. Gore JC, Xu J, Colvin DC, Yankeelov TE, Parsons EC, Does MD. Characterization of tissue structure at varying length scales using temporal diffusion spectroscopy. NMR IN BIOMEDICINE. 2010;23(7):745-56. doi: 10.1002/nbm.1531. [doi]
10. Lee H-H, Papaioannou A, Novikov DS, Fieremans E. In vivo observation and biophysical interpretation of time-dependent diffusion in human cortical gray matter. NEUROIMAGE. 2020;222. doi: 10.1016/j.neuroimage.2020.117054. [doi]
11. Xu J, Devan SP, Shi D, Pamulaparthi A, Yan N, Zu Z, et al. MATI: A GPU-accelerated toolbox for microstructural diffusion MRI simulation and data fitting with a graphical user interface. Magnetic Resonance Imaging. 2025;122:110428. doi: https://doi.org/10.1016/j.mri.2025.110428. [doi]
12. Jiang X, Devan SP, Xie J, Gore JC, Xu J. Improving MR cell size imaging by inclusion of transcytolemmal water exchange. Nmr in Biomedicine. 2022;35(12). doi: 10.1002/nbm.4799. [doi]
13. Dong T, Lee H-H, Zang H, Lee H, Tian Q, Wan L, et al. In vivo cortical microstructure mapping using high-gradient diffusion MRI accounting for intercompartmental water exchange effects. NeuroImage. 2025;314:121258. doi: https://doi.org/10.1016/j.neuroimage.2025.121258. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/467-05-003