Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-05-006 ISMRM Abstract

Metabolite changes in the SOD1 transgenic mouse model of ALS using magnetic resonance spectroscopy

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Neuro - Other Neurodegeneration
362-05-006 · Spectroscopy and Spectroscopic Imaging: Neuro II · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row C
Keywords: Metabolism Neurodegeneration Histology Preclinical MRS Amyotrophic lateral sclerosis
Accepted
Colleen Bailey1, Hussein Ghazale2, EunJee Park2,3, Carol Schuurmans2,3,4, Jamie Near 1,5
1Physical Science Platform, Sunnybrook Research Institute, Toronto, Canada
2Biological Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
3Department of Biochemistry, University of Toronto, Toronto, Canada
4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
5Department of Medical Biophysics, University of Toronto, Toronto, Canada
Presenting Author: Jamie Near

Synopsis

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References

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5. Foerster, B. R.; Pomper, M. G.; Callaghan, B. C.; Petrou, M.; Edden, R. A. E.; Mohamed, M. A.; Welsh, R. C.; Carlos, R. C.; Barker, P. B.; Feldman, E. L. An Imbalance Between Excitatory and Inhibitory Neurotransmitters in Amyotrophic Lateral Sclerosis Revealed by Use of 3-T Proton Magnetic Resonance Spectroscopy. JAMA Neurol. 2013, 70 (8), 1009–1016. https://doi.org/10.1001/jamaneurol.2013.234. [doi]
6. Vinsant, S.; Mansfield, C.; Jimenez-Moreno, R.; Del Gaizo Moore, V.; Yoshikawa, M.; Hampton, T. G.; Prevette, D.; Caress, J.; Oppenheim, R. W.; Milligan, C. Characterization of Early Pathogenesis in the SOD1G93A Mouse Model of ALS: Part I, Background and Methods. Brain Behav. 2013, 3 (4), 335–350. https://doi.org/10.1002/brb3.143. [doi]
7. Weerasekera, A.; Sima, D. M.; Dresselaers, T.; Van Huffel, S.; Van Damme, P.; Himmelreich, U. Non-Invasive Assessment of Disease Progression and Neuroprotective Effects of Dietary Coconut Oil Supplementation in the ALS SOD1G93A Mouse Model: A 1H-Magnetic Resonance Spectroscopic Study. NeuroImage Clin. 2018, 20, 1092–1105. https://doi.org/10.1016/j.nicl.2018.09.011. [doi]
8. Lei, H.; Dirren, E.; Poitry-Yamate, C.; Schneider, B. L.; Gruetter, R.; Aebischer, P. Evolution of the Neurochemical Profiles in the G93A-SOD1 Mouse Model of Amyotrophic Lateral Sclerosis. J. Cereb. Blood Flow Metab. 2019, 39 (7), 1283–1298. https://doi.org/10.1177/0271678X18756499. [doi]
9. Fowler, C. F.; Madularu, D.; Dehghani, M.; Devenyi, G. A.; Near, J. Longitudinal Quantification of Metabolites and Macromolecules Reveals Age- and Sex-Related Changes in the Healthy Fischer 344 Rat Brain. Neurobiol. Aging 2021, 101, 109–122. https://doi.org/10.1016/j.neurobiolaging.2020.12.012. [doi]
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http://echo.ismrm.org/p/ISMRM2026/362-05-006