Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
563-01-014 ISMRM Abstract

Brainstem Mapping in Parkinson’s Disease with and without Apathy Using MP2RAGE‑FLAWS MRI at 3T

Primary: Neuro - Parkinson's Disease
Secondary: Analysis Methods - Segmentation and Detection
563-01-014 · Novel Neuro Applications · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row D
Keywords: Parkinson's Disease 3T MRI MP2RAGE-FLAWS Brainstem Mapping Apathy
Accepted
Hui Zhang 1, Pubing Yuan1, Miriam Vignando2, Shirley Yin Yu Pang3, Yushan Feng1, Tom Hilbert4,5,6, Gian Franco Piredda4, Celia M. Dong7, Juan Wei8, Mitul Mehta2, David H.K. Shum1, Ka Fung Henry Mak9
1Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, Hong Kong
2Department of Neuroimaging, King's College London, London, United Kingdom
3Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong
4Swiss Innovation Hub, Siemens Healthineers International AG, Lausanne, Switzerland
5LTS5, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
6Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
7University Research Facility in Behavioral and Systems Neuroscience, The Hong Kong Polytechnic University, Hong Kong, Hong Kong
8MR Collaborations, Siemens Healthineers Ltd., Beijing, China
9Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Presenting Author: Hui Zhang

Synopsis

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References

1. Han JW, Ahn YD, Kim W-S, et al. Psychiatric manifestation in patients with Parkinson's disease. Journal of Korean medical science. 2018;33(47):e300. doi: 10.3346/jkms.2018.33.e300 [doi]
2. Bloem BR, Okun MS, Klein C. Parkinson's disease. The Lancet. 2021;397(10291):2284-2303. doi: 10.1016/S0140-6736(21)00218-X [doi]
3. Gazes Y, Suzuki H, Morris LA, et al. A transdiagnostic, multi-modal approach to understanding apathy: Methodological and analytical framework. Neuroimage Rep. Dec 2025;5(4):100289. doi:10.1016/j.ynirp.2025.100289 [doi]
4. Urushibata Y, Kuribayashi H, Fujimoto K, et al. Advantages of fluid and white matter suppression (FLAWS) with MP2RAGE compared with double inversion recovery turbo spin echo (DIR-TSE) at 7T. Eur J Radiol. Jul 2019;116:160-164. doi:10.1016/j.ejrad.2019.04.019 [doi]
5. Mueller SG. Mapping internal brainstem structures using MP2RAGE derived T1 weighted and T1 relaxation images at 3 and 7 T. Hum Brain Mapp. Jun 1 2020;41(8):2173-2186. doi:10.1002/hbm.24938 [doi]
6. Béreau M, Van Waes V, Servant M, Magnin E, Tatu L, Anheim M. Apathy in Parkinson’s disease: Clinical patterns and neurobiological basis. Cells. 2023;12(12):1599. doi: 10.3390/cells12121599 [doi]
7. Moqadam R, Azizi H, Brzezinski-Rittner A, et al. Apathy progression is associated with brain atrophy and white matter damage in Parkinson's disease. Brain Commun. 2025;7(5):fcaf355. doi:10.1093/braincomms/fcaf355 [doi]
8. Prange S, Metereau E, Maillet A, et al. Early limbic microstructural alterations in apathy and depression in de novo Parkinson's disease. Mov Disord. Nov 2019;34(11):1644-1654. doi:10.1002/mds.27793 [doi]

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http://echo.ismrm.org/p/ISMRM2026/563-01-014