Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
668-02-001 ISMRM Abstract

1H-MRS brain metabolites as biomarkers of high-altitude hypobaric hypoxia following mild traumatic brain injury in mice

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Neuro - Traumatic Brain Injury
668-02-001 · Spectroscopy and Spectroscopic Imaging: Applications · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row I
Keywords: Preclinical MRS High-altitude adaptation MTBI 1H MRS Hypobaric hypoxia
Accepted
Young Woo Park 1,2, Alexandru Korotcov1,2, Asamoah Bosomtwi1,2,3, Nathan Cramer1,4,5, Xiufen Xu1,4, Dinesh K Deelchand6, Malgorzata Marjanska6, Zygmunt Galdzicki4
1The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, United States of America
2Department of Radiology and Bioengineering, Uniformed Services University of the Health Sciences, Bethesda, United States of America
3Georgia Cancer Center, Augusta University, Augusta, United States of America
4Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, United States of America
6University of Minnesota, CMRR, United States of America
Presenting Author: Young Woo Park

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References

1. Cramer NP, Korotcov A, Bosomtwi A, et al. Neuronal and vascular deficits following chronic adaptation to high altitude. Experimental Neurology. 2019;311:293-304. doi:10.1016/j.expneurol.2018.10.007 [doi]
2. Rauch S, Marzolo M, Dal Cappello T, et al. Severe traumatic brain injury and hypotension is a frequent and lethal combination in multiple trauma patients in mountain areas – an analysis of the prospective international Alpine Trauma Registry. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2021;29(1):61. doi:10.1186/s13049-021-00879-1 [doi]
3. Li AY, Durbin JR, Hannah TC, et al. High altitude modulates concussion incidence, severity, and recovery in young athletes. Brain Injury. 2022;36(6):733-739. doi:10.1080/02699052.2022.2035435 [doi]
4. Yang Y, Peng Y, He S, Wu J, Xie Q, Ma Y. The Clinical Differences of Patients With Traumatic Brain Injury in Plateau and Plain Areas. Front Neurol. 2022;13. doi:10.3389/fneur.2022.848944 [doi]
5. Shaw NA. The neurophysiology of concussion. Prog Neurobiol. 2002;67(4):281-344. doi:10.1016/s0301-0082(02)00018-7 [doi]
6. Silverberg ND, Iverson GL, Cogan A, et al. The American Congress of Rehabilitation Medicine Diagnostic Criteria for Mild Traumatic Brain Injury. Archives of Physical Medicine and Rehabilitation. 2023;104(8):1343-1355. doi:10.1016/j.apmr.2023.03.036 [doi]
7. Korotcov A, Browne CA, Bosomtwi A, et al. A longitudinal neuroimaging study in mice on the effects of chronic high altitude exposure and repetitive traumatic brain injury. In: Proc. Intl. Soc. Mag. Reson. Med. 2023; 2023. https://archive.ismrm.org/2023/1706.html. Accessed October 20, 2025.
8. Logue OC, Cramer NP, Xu X, Perl DP, Galdzicki Z. Alterations of functional properties of hippocampal networks following repetitive closed-head injury. Experimental Neurology. 2016;277:227-243. doi:10.1016/j.expneurol.2015.12.019 [doi]
9. Signoretti S, Di Pietro V, Vagnozzi R, et al. Transient alterations of creatine, creatine phosphate, N-acetylaspartate and high-energy phosphates after mild traumatic brain injury in the rat. Mol Cell Biochem. 2010;333(1-2):269-277. doi:10.1007/s11010-009-0228-9 [doi]
10. Vagnozzi R, Signoretti S, Floris R, et al. Decrease in N-acetylaspartate following concussion may be coupled to decrease in creatine. J Head Trauma Rehabil. 2013;28(4):284-292. doi:10.1097/HTR.0b013e3182795045 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/668-02-001