Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-02-010 ISMRM Abstract

Microstructural imaging of Glioblastoma tumours using ultra-strong gradient and multi-dimensional diffusion MRI

Primary: Diffusion - Diffusion Acquisition
Secondary: Diffusion - Diffusion Analysis & Visualization
362-02-010 · Clinical Diffusion Neuro · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row C
Keywords: Glioblastoma Ultra-strong gradients Tumour heterogeneity Radial profiling Tumour progression
Accepted
Muhammad Usman Akbar 1,2, Michael Law1, Jennifer Golten1,3, Najmus Sahar Iqbal3, Elise Gwyther1, George Eralil3, Harpreet Hyare4, Hannah Khirwadkar5, Kathy Seddon6, Matteo Figini7, Eleftheria Panagiotaki7, Florien Siebzehnrubl8, Derek K Jones1, James Powell3, Marco Palombo1,2
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom
2School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom
3Velindre cancer centre, Velindre Rd, CF14 2TL, Cardiff, United Kingdom
4Department of Translational Neuroscience and Stroke, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom
5Swansea Bay University Health Board, Morriston Hospital, United Kingdom
6Public and Patient Representative, Wales Cancer Research Centre, United Kingdom
7Hawkes Institute, Department of Computer Science, University College London, London, United Kingdom
8European Cancer Stem Cell Research Institute, Cardiff University, Cardiff, United Kingdom
Presenting Author: Muhammad Usman Akbar

Synopsis

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References

1. Brandes, Alba A., et al. "Glioblastoma in adults." Critical reviews in oncology/hematology 67.2 (2008): 139-152.
2. Cantidio, Farley Soares, et al. "Glioblastoma—treatment and obstacles." Reports of Practical Oncology and Radiotherapy 27.4 (2022): 744-753.
3. Messina, Carmelo, et al. "Diffusion-weighted imaging in oncology: an update." Cancers 12.6 (2020): 1493.
4. Drake-Pérez, Marta, et al. "Clinical applications of diffusion weighted imaging in neuroradiology." Insights into imaging 9.4 (2018): 535-54
5. O'Connor, James PB, et al. "Imaging intratumor heterogeneity: role in therapy response, resistance, and clinical outcome." Clinical Cancer Research 21.2 (2015): 249-257.
6. Alexander, Daniel C., et al. "Imaging brain microstructure with diffusion MRI: practicality and applications." NMR in Biomedicine 32.4 (2019): e3841.
7. Figini, Matteo, et al. "Comprehensive brain tumour characterisation with VERDICT-MRI: evaluation of cellular and vascular measures validated by histology." Cancers 15.9 (2023): 2490
8. Gerstner, Elizabeth R., Matthew P. Frosch, and Tracy T. Batchelor. "Diffusion magnetic resonance imaging detects pathologically confirmed, nonenhancing tumor progression in a patient with recurrent glioblastoma receiving bevacizumab." Journal of Clinical Oncology 28.6 (2010): e91-e93.
9. Topgaard, Daniel. "Multidimensional diffusion MRI." Journal of magnetic resonance 275 (2017): 98-113.
10. Palombo, Marco, et al. "Joint estimation of relaxation and diffusion tissue parameters for prostate cancer with relaxation-VERDICT MRI." Scientific Reports 13.1 (2023): 2999.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/362-02-010