Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-05-013 ISMRM Abstract

Identification of Downfield Resonances in Human Brain Using 3T MRS:Comparison of Metabolite-Cycling and Narrowband Excitation

Accepted
Ajin Joy1, Andres Saucedo2, Paul M Macey3, Karin Nielsen-Saines4, Rajakumar Nagarajan 5,6, uzay emir7,8,9,10, Arun Karlamangla4, Ebrahim Haroon, Michael A Thomas2
1Department of Radiological Sciences, David Geffen School of Medicine at University of California, Los Angeles, United States of America
2Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, United States of America
3University of California Los Angeles, Los Angeles, United States of America
4David Geffen School of Medicine, University of California Los Angeles, Los Angeles, United States of America
5Human Magnetic Resonance Center, University of Massachusetts Amherst, Amherst, United States of America
6Human Magnetic Resonance Center, Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, United States of America
7University of North Carolina at Chapel Hill, Chapel Hill, United States of America
8Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
9Lampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
10Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
Presenting Author: Rajakumar Nagarajan

Synopsis

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References

1. Cuenoud B, Ipek O, Shevlyakova M, et al. Brain NAD is associated with ATP energy production and membrane phospholipid turnover in humans. Frontiers in Aging Neuroscience 2020;12:609517.
2. de Graaf RA, Behar KL. Detection of cerebral NAD(+) by in vivo (1)H NMR spectroscopy. NMR Biomed. 2014;27:802-809.
3. de Graaf RA, de Feyter HM, Brown PB, Nixon T, Rothman D, Behar K. Detection of cerebral NAD(+) in humans at 7T. Magn Reson Med. 2017;78:828-835.
4. Bagga P, Hariharan H, Wilson NE, et al. Single-voxel 1H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD+) in humans at 7T using a 32-channel volume coil. Magn Reson Med. 2020;83:806-814.
5. Dziadosz M, Hoefemann M, Doring A, et al. Quantification of NAD+ in human brain with 1HMR spectroscopy at 3 T: Comparison of three localization techniques with different handling of water magnetization. Magn Reason Med 2022;88:1027-1038
6. Wilson NE, Elliott MA, Nanga RPR, et al. Optimization of 1H-MRS methods for large-volume acquisition of low-concentration downfield resonances at 3T and 7 T. Magn Reason Med 2025;93:18-30;
7. Swago S, Wilson NE, Elliott MA, Reddy R, Witschey WR, Nanga RPR. Quantification of Tryptophan and NAD +  Proton Magnetization Exchange With Water Using Downfield  1 HMRS in the Human Brain at 7 T.Magn Reson Med. 2025 Oct 14.
8. Nanga RPR, Elliott MA, Swain A, et al. Identification of new resonances in downfield (1)HMRS of human calf muscle in vivo: Potentially metabolites precursors for skeletal muscle NAD. Magn Reson Med 2023;90:1166-1177..
9. Özdemir İ, Etyemez S, Barker PB. High-field downfield MR spectroscopic imaging in the human brain. Magn Reson Med. 2024 Sep;92(3):890-899. Epub 2024 Mar 12.
10. Swago S, Elliott MA, Nanga RPR, Wilson NE, Cember A, Reddy R, Witschey WR. Quantification of cross-relaxation in downfield (1) H MRS at 7 T in human calf muscle. Magn Reson Med. 2023 Jul;90(1):11-20. Epub 2023 Feb 18.
11. Borbath T, Murali-Manohar S, Wright AM, Henning A. In vivo characterization of downfield peaks at 9.4 T: T(2) relaxation times, quantification, pH estimation, and assignments. Magn Reson Med. 2021 Feb;85(2):587-600. Epub 2020 Aug 11.
12. Fichtner ND, Giapitzakis IA, Avdievich N, Mekle R, Zaldivar D, Henning A, Kreis R. In vivo characterization of the downfield part of (1) H MR spectra of human brain at 9.4 T:Magnetization exchange with water and relation to conventionally determined metabolite content. Magn Reson Med. 2018 Jun;79(6):2863-2873. Epub 2017 Oct 16.
13. Sarma MK, Henning A. In Vivo Characterization and Identification of Novel Resonances in the Downfield ¹H MRS of Human Skeletal Muscle/Calf Muscle at 3T. Proc. Intl. Soc. Mag. Reson. Med. 33 (2025) 4514.
14. Dreher W, Leibfritz D. New method for the simultaneous detection of metabolites and water in localized in vivo 1H nuclear magnetic resonance spectroscopy. Magn Reson Med. 2005;54(1):190‐195.
15. Hock A, MacMillan EL, Fuchs A, Kreis R, Boesiger P, Kollias SS, Henning A. Non‐water‐suppressed proton MR spectroscopy improves spectral quality in the human spinal cord. Magn Reson Med. 2013;69(5):1253‐1260.
16. Emir UE, Burns B, Chiew M, Jezzard P, Thomas MA. Non-water-suppressed short echo-time magnetic resonance spectroscopic imaging using a concentric ring k-space trajectory. NMR Biomed 2017;30e3714.
17. Peereboom SM, Kozerke S. Metabolite-cycled echo-planar spectroscopic imaging of the human heart. Magn Reason Med 2022;88:1516-1527.
18. Garwood M, DeLaBarre L. The return of the frequency sweep: designing adiabatic pulses for contemporary NMR. J Magn Reson 2001;153:155-177.
19. Scheenen, T. W., Klomp, D. W., Wijnen, J. P. & Heerschap, A. Short echo time 1H-MRSI of the human brain at 3T with minimal chemical shift displacement errors using adiabatic refocusing pulses. Magn Reason Med 2008;59:1–6.
20. Ogg RJ, Kingsley R, Taylor JS (1994) WET, a T1-and B1-insensitive water-suppression method for in vivo localized 1H NMR spectroscopy. J Magn Reson Ser B 104(1):1–10
21. Považan M, Schär M, Gillen J, Barker PB. Magnetic resonance spectroscopic imaging of downfield proton resonances in the human brain at 3 T. Magnetic resonance in medicine. 2022 Apr;87(4):1661-72.
22. McReynolds MR, Chellappa K, Baur JA. Age-related NAD+ decline. Experimental gerontology. 2020 Jun 1;134:110888.
23. Vinten KT, Tretowicz MM, Coskun E, et al. NAD+ precursor supplementation in human ageing: Clinical evidence and challenges. Nat Metab 2025; 7:1974-1990.

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