Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-02-007 ISMRM Abstract

Dynamic diffusion-weighted imaging reveals compromised paravascular pulsatility in alzheimer’s disease mice at 9.4T

Primary: Diffusion - DWI/DTI/DKI
Secondary: Physics & Engineering - High-Field MRI
663-02-007 · Diffusion: DWI/DTI/DKI · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row D
Keywords: Alzheimer's Disease Glymphatic system (GS) Perivascular spaces (PVS) Cerebrospinal fluid (CSF) dynamics DynDWI
Accepted
Yuqin Min1, Huang Ning1,2, Mingyan Wu1,3, Xiangwei Zhu1,3, Qiuting Wen4, Xingfeng Shao1,5, Fuhua Yan1,2,5
1Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Advanced Technology Research Institute, Shanghai United Imaging Co., Ltd, Shanghai, China
4Indiana University School of Medicine, Indianapolis, United States of America
5College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Presenting Author: Jiekai Zhu

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References

1. Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Science translational medicine. 2012;4(147):147ra11-ra11. doi: 10.1126/scitranslmed.3003748 [doi]
2. Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. The Lancet Neurology. 2018;17(11):1016-24. doi:10.1016/S1474-4422(18)30318-1 [doi]
3. Harrison IF, Siow B, Akilo AB, Evans PG, Ismail O, Ohene Y, et al. Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI. Elife. 2018;7:e34028. doi: 10.7554/eLife.34028 [doi]
4. Hirschler L, Runderkamp BA, Decker A, van Harten TW, Scheyhing P, Ehses P, et al. Region-specific drivers of CSF mobility measured with MRI in humans. Nature Neuroscience. 2025:1-10. doi: 10.1038/s41593-025-02073-3 [doi]
5. Wen Q, Tong Y, Zhou X, Dzemidzic M, Ho CY, Wu Y-C. Assessing pulsatile waveforms of paravascular cerebrospinal fluid dynamics within the glymphatic pathways using dynamic diffusion-weighted imaging (dDWI). Neuroimage. 2022;260:119464. doi: 10.1016/j.neuroimage.2022.119464 [doi]
6. Peng W, Achariyar T M, Li B, et al. Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease[J]. Neurobiology of disease, 2016, 93: 215-225. doi: 10.1016/j.nbd.2016.05.015 [doi]
7. Mestre H, Tithof J, Du T, et al. Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension[J]. Nature communications, 2018, 9(1): 4878. doi: 10.1038/s41467-018-07318-3 [doi]
8. Bedussi B, Almasian M, de Vos J, et al. Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow[J]. Journal of Cerebral Blood Flow & Metabolism, 2018, 38(4): 719-726. doi: 10.1177/0271678X17737984 [doi]

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http://echo.ismrm.org/p/ISMRM2026/663-02-007