Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
366-04-005 ISMRM Abstract

Cu-MNP-PEGs Enable MRI-Guided Hyperthermia-Enhanced Chemodynamic Therapy against Glioblastoma through Cuproptosis

Primary: Preclinical Animal & in vitro MR - Probes & Targets
Secondary: Preclinical Animal & in vitro MR - Small Animals
366-04-005 · Probes and Targets · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row G
Keywords: Magnetic Resonance Imaging (MRI) Glioblastoma Melanin Nanoparticle Cuproptosis Hyperthermia-Enhanced Chemodynamic Therapy
Accepted
Ying Shi 1, Wenshuang Wang1, Pengfei Liu1, jianxiu lian2,3,4
1The First Affiliated Hospital of Harbin Medical University, Harbin, China
2Philips Healthcare, Guangzhou, China
3Clinical and Technical Support, Philips Healthcare (Beijing), Beijing, China
4Philips Healthcare (Beijing), Beijing, China
Presenting Author: Ying Shi

Synopsis

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References

1. Brian M A, Timothy F C (2017) Adult Glioblastoma, J Clin Oncol 35 (21). 10.1200/jco.2017.73.0119. [doi]
2. Jigisha P T, Therese A D, Craig H, et al. (2014) Epidemiologic and molecular prognostic review of glioblastoma, Cancer Epidemiol Biomarkers Prev 23 (10). 10.1158/1055-9965.Epi-14-0275. [doi]
3. Elena O, Paz M-M, María O-C, et al. (2024) Glioblastoma Therapy: Past, Present and Future, Int J Mol Sci 25 (5). 10.3390/ijms25052529. [doi]
4. Yue Y, Zhao X. (2021) Melanin-Like Nanomedicine in Photothermal Therapy Applications. Int J Mol Sci 22(1):399.
5. Lesley J, Scott.(2018). Gadobutrol: A Review in Contrast-Enhanced MRI and MRA. Clin Drug Investig, 38(8), 773-784. doi:10.1007/s40261-018-0674-9 [doi]
6. Jia, W H, Tian H L, Jiang J W, et al.(2022). Brain-Targeted HFn-Cu-REGO Nanoplatform for Site-Specific Delivery and Manipulation of Autophagy and Cuproptosis in Glioblastoma. Small, 19(2), e2205354. doi:10.1002/smll.202205354 [doi]
7. Tsvetkov P, Coy S, Petrova B, et al.(2022). Copper induces cell death by targeting lipoylated TCA cycle proteins. Science, 375(6586), 1254-1261. doi:10.1126/science.abf0529 [doi]
8. Huang C H., Chang E, Zheng L, et al.(2023). Tumor protease-activated theranostic nanoparticles for MRI-guided glioblastoma therapy. Theranostics, 13(6), 1745-1758. doi:10.7150/thno.79342 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/366-04-005