Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
462-01-001 ISMRM Abstract

Delineation and Characterization of Magnetization Transfer Attenuated Tumour Sub-Regions using Unsupervised Clustering

Primary: Neuro - Tumors
Secondary: Contrast Mechanisms - Magnetization Transfer
462-01-001 · Contrast Mechanisms Potpourri Including Registered/Clinical Abstracts · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row C
Keywords: Brain Metastasis Clustering analysis Gaussian Mixture Model Tumor habitat Magnetization Transfer Ratio
Accepted
Céline Dubroy-McArdle 1,2, Wilfred W Lam3, Greg Stanisz3,4,5, Dafna Sussman1,2,6
1Electrical, Computer and Biomedical Engineering, Toronto Metropolitan University, Toronto, Canada
2Institute for Biomedical Engineering, Science and Technology (iBEST), St. Michael's Hospital, Toronto, Canada
3Department of Physical Sciences, Sunnybrook Research Institute, Toronto, Canada
4Department of Medical Biophysics, University of Toronto, Toronto, Canada
5Department of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland
6Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Canada
Presenting Author: Céline Dubroy-McArdle

Synopsis

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References

1. Achrol AS, Rennert RC, Anders C, Soffietti R, Ahluwalia MS, Nayak L, et al. Brain metastases. Vol. 5, Nature Reviews Disease Primers. Nature Publishing Group; 2019. doi:10.1038/s41572-018-0055-y. [doi]
2. Mitchell DK, Kwon HJ, Kubica PA, Huff WX, O’Regan R, Dey M. Brain metastases: An update on the multi-disciplinary approach of clinical management. Neurochirurgie. 2022;68(2):69-85. doi:10.1016/j.neuchi.2021.04.001. [doi]
3. Gondi V, Bauman G, Bradfield L, Burri SH, Cabrera AR, Cunningham DA, et al. Radiation Therapy for Brain Metastases: An ASTRO Clinical Practice Guideline. Pract Radiat Oncol. 2022 Jul 1;12(4):265–82. doi:10.1016/j.prro.2022.02.003. [doi]
4. Mehrabian H, Detsky J, Soliman H, Sahgal A, Stanisz GJ. Advanced magnetic resonance imaging techniques in management of brain metastases. Front Oncol. 2019;9. doi: 10.3389/fonc.2019.00440. [doi]
5. Lam WW, Oakden W, Karami E, Koletar MM, Murray L, Liu SK, Sadeghi-Naini A, Stanisz GJ. An automated segmentation pipeline for intratumoural regions in animal xenografts using machine learning and Saturation Transfer MRI. Scientific Reports. 2020 May; 10(1). doi:10.1038/s41598-020-64912-6 [doi]
6. Chan RW, Lam W, Chen H, Murray L, Zhang B, Theriault A, et al. Is pulsed saturation transfer sufficient for differentiating radiation necrosis from tumor progression in brain metastases? Neurooncol Adv. 2024 Jan 1;6(1). doi:10.1093/noajnl/vdae132. [doi]
7. Mehrabian H, Desmond KL, Soliman H, Sahgal A, Stanisz GJ. Differentiation between radiation necrosis and tumor progression using chemical exchange saturation transfer. Clinical Cancer Research. 2017 Jul 15;23(14):3667–75. doi:10.1158/1078-0432.CCR-16-2265. [doi]

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http://echo.ismrm.org/p/ISMRM2026/462-01-001