Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
665-03-006 ISMRM Abstract

Investigating brain network adaptations to light exercise and perceived effort in Fibromyalgia and Long-COVID

Primary: Brain Function and fMRI - Functional Connectivity
Secondary: Neuro - Neuroinflammation
665-03-006 · fMRI: Applications in Neurology and Psychiatry III · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row F
Keywords: Brain Connectivity Functional magnetic resonance imaging Fibromyalgia Chronic fatigue Long Covid
Accepted
Aneurin J Kennerley 1, Oliver J Mundell1, Elisa Zamboni2, Fabio Zambolin1,3,4,5, William J Gregory6,7, Jamie S McPhee1,3,4,5
1Department of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester, United Kingdom
2School of Psychology, School of Psychology, University of Nottingham, Nottingham, United Kingdom
3Manchester Metropolitan University, Manchester, United Kingdom
4Manchester Metropolitan Institute of Sport, Manchester Metropolitan University, Manchester, United Kingdom
5Wolfson ACTIVE Imaging Laboratory, Manchester Metropolitan University, Manchester, United Kingdom
6Rheumatology Department, Salford Care Organisation NHS foundation Trust, Manchester, United Kingdom
7Faculty of Health and Education, Manchester Metropolitan University, Manchester, United Kingdom
Presenting Author: Aneurin J Kennerley

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References

1. Charlton, B.T., Goulding, R.P., Jaspers, R.T., Appelman, B., van Vugt, M., and Wüst, R.C.I. (2025). Skeletal muscle adaptations and post-exertional malaise in long COVID. Trends Endocrinol. Metab. 36, 614–622. https://doi.org/10.1016/j.tem.2024.11.008. [doi]
2. Barhorst, E.E., Boruch, A.E., Cook, D.B., and Lindheimer, J.B. (2021). Pain-related post-exertional malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia: A systematic review and three-level meta-analysis. Pain Med.
3. Zambolin, F., Duro-Ocana, P., Faisal, A., Bagley, L., Gregory, W.J., Jones, A.W., and McPhee, J.S. (2022). Fibromyalgia and Chronic Fatigue Syndromes: A systematic review and meta-analysis of cardiorespiratory fitness and neuromuscular function compared with healthy individuals. PLoS One 17, e0276009. https://doi.org/10.1371/journal.pone.0276009. [doi]
4. Krüger, A.L., Haiduk, B., and Grau, M. (2024). Identifying Factors That Might Affect Outcomes of Exercise-Based Therapies in Long-COVID. Diseases. 12.
5. Fontes, E.B., Okano, A.H., De Guio, F., Schabort, E.J., Min, L.L., Basset, F.A., Stein, D.J., and Noakes, T.D. (2015). Brain activity and perceived exertion during cycling exercise: an fMRI study. Br. J. Sports Med. 49, 556–560. https://doi.org/10.1136/bjsports-2012-091924. [doi]
6. Fontes, E.B., Bortolotti, H., Grandjean da Costa, K., Machado de Campos, B., Castanho, G.K., Hohl, R., Noakes, T., and Min, L.L. (2020). Modulation of cortical and subcortical brain areas at low and high exercise intensities. Br. J. Sports Med. 54, 110–115. https://doi.org/10.1136/bjsports-2018-100295. [doi]
7. Whitfield-Gabrieli, S., and Nieto-Castanon, A. (2012). Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connect. 2, 125–141. https://doi.org/10.1089/brain.2012.0073. [doi]
8. Nieto-Castanon, A. & Whitfield-Gabrieli, S. CONN functional connectivity toolbox: RRID SCR_009550, release 22. (2022). doi:10.56441/hilbertpress.2246.5840 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/665-03-006