Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026
· Cape Town, South Africa
404-03-007
ISMRM Abstract
Neuroinflammation Induced Changes in Brain Energy Metabolism in A Mouse Model of Astrogliosis using 2H MR Spectroscopy
Primary:
Neuro - Neuroinflammation
Secondary:
Preclinical Animal & in vitro MR - Biomarkers
404-03-007 · Multiscale MRI in Neuroinflammation
· Tuesday, 12 May, 1:40 PM–3:30 PM · Ballroom East
Keywords:Alzheimer's DiseaseNeuroinflammationBrain energy metabolismAstrogliosisDeuterium MRS
Accepted
Narayan Datt Soni1, Dipak Roy1, Abeer Mathur1, Anshuman Swain1, Sunil K Khokhar1, Paul S Jacobs1, Blake A Benyard 1, Halvor Juul1, Dushyant Kumar1, RAVI PRAKASH REDDY NANGA1, Ravinder Reddy1, Mohammad Haris1
1Department of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), University of Pennsylvania, Philadelphia, United States of America
Presenting Author: Blake A Benyard
Synopsis
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2. Zhang, Y., Chen, H., Li, R., Sterling K, Song, W. Amyloid β-based therapy for Alzheimer's disease: challenges, successes and future. Signal Transduct Target Ther. 2023, 8(1):248.
3. Kepp KP, Robakis NK, Høilund-Carlsen PF, Sensi SL, Vissel B. The amyloid cascade hypothesis: an updated critical review. Brain 2023, 146(10):3969-3990.
4. Soni ND, Ramesh A, Roy D, Patel AB. Brain energy metabolism in intracerebroventricularly administered streptozotocin mouse model of Alzheimer's disease: A 1H-[13C]-NMR study. J Cereb Blood Flow Metab. 2021, 41(9):2344-2355.
5. Patel AB, Tiwari V, Veeraiah P, Saba K. Increased astroglial activity and reduced neuronal function across brain in AβPP-PS1 mouse model of Alzheimer's disease. J Cereb Blood Flow Metab. 2018, 38(7):1213-1226.
6. Newcombe EA, Camats-Perna J, Silva ML, Valmas N, Huat TJ, Medeiros R. Inflammation: the link between comorbidities, genetics, and Alzheimer's disease. J Neuroinflammation. 2018, 15(1):276.
7. Griciuc A and Tanzi RE. The role of innate immune genes in Alzheimer's disease. Curr Opin Neurol. 2021, 34(2):228-236.
8. Boyd RJ, Avramopoulos D, Jantzie LL, McCallion AS. Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases. J Neuroinflammation. 2022, 19(1):223.
9. Long C, Fritts A, Broadway J, Brawman-Mintzer O, Mintzer J. Neuroinflammation: A Driving Force in the Onset and Progression of Alzheimer's Disease. J Clin Med. 2025, 14(2):331.
10. Chakravorty A, Jetto CT, Manjithaya R. Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer's Disease Pathogenesis. Front Aging Neurosci. 2019, 11:311.
11. Soni ND, Swain A, Jacobs P. In vivo assessment of beta-hydroxybutyrate metabolism in mouse brain using deuterium ((2) H) MRS. Magn Reson Med. 2023, 90:259-269.
12. Lu M, Zhu XH, Zhang Y. Quantitative assessment of brain glucose metabolic rates using in vivo deuterium magnetic resonance spectroscopy. J Cereb Blood Flow Metab. 2017, 37:3518-3530.
13. Nam MH, Ko HY, Kim D, Lee S, Park YM, Hyeon SJ, Won W, Chung JI, Kim SY, Jo HH, Oh KT, Han YE, Lee GH, Ju YH, Lee H, Kim H, Heo J, Bhalla M, Kim KJ, Kwon J, Stein TD, Kong M, Lee H, Lee SE, Oh SJ, Chun JH, Park MA, Park KD, Ryu H, Yun M, Lee CJ. Visualizing reactive astrocyte-neuron interaction in Alzheimer's disease using 11C-acetate and 18F-FDG. Brain 2023, 46(7):2957-2974.
14. Song KH, Ge X, Engelbach JA, Thio LL, Neil JJ, Ackerman JJH, Garbow JR. Subcutaneous deuterated-substrate administration in mice: An alternative to tail vein infusion. Magn Reson Med. 2024, 91(2):681-686.