551-03-013 / 551-03-013 ISMRM Abstract

Cholinergic Inflammation and Metabolic Dysfunction Predict Dementia Conversion in Alzheimer’s Disease: A 3D-MRSI/PET Study

Primary: Neuro - Alzheimer's Disease

Secondary: Neuro - Dementia

551-03-013 · Advanced MRI Biomarkers of Brain Aging, Vascular Health, and Alzheimer’s Disease · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 1

Keywords: Alzheimer's Disease Neuroinflammation MRSI Metabolic imaging PET-MRI

Accepted

Yue Guan^1,2, Miao Zhang³, Shuoyun Feng¹, Wenli Li ¹, Yudu Li^4,5,6, Yibo Zhao⁴, Wen Jin^4,7, Yaoyu Zhang^1,2, Wenqi Zhang¹, Xinyu Guo¹, Huixiang Zhuang¹, Zhi-Pei Liang^4,7, Yao Li^1,2

¹National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

²Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, China

³Ruijin Hospital, Shanghai, China

⁴Beckman Institute for Advanced Sciences and Technology, University of Illinois at Urbana-Champaign, Champaign, United States of America

⁵The National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Champaign, United States of America

⁶University of Illinois at Urbana-Champaign, Champaign, United States of America

⁷Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Champaign, United States of America

Presenting Author: Wenli Li

Synopsis

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References

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3. Schumacher J, Ray N J, Hamilton C A, et al. Cholinergic white matter pathways in dementia with Lewy bodies and Alzheimer’s disease[J]. Brain, 2022, 145(5): 1773-1784. doi: 10.1093/brain/awab372. [doi]

4. Nemy M, Dyrba M, Brosseron F, et al. Cholinergic white matter pathways along the Alzheimer's disease continuum[J]. Brain, 2023, 146(5): 2075-2088. doi: 10.1093/brain/awac385. [doi]

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7. Zhao Y, Li Y, Jin W, et al. Ultrafast J-resolved magnetic resonance spectroscopic imaging for high-resolution metabolic brain imaging[J]. Nature biomedical engineering, 2025: 1-13. doi: 10.1038/s41551-025-01418-4. [doi]

8. Vu AT, Auerbach E, Lenglet C, et al. High resolution whole brain diffusion imaging at 7 T for the human connectome project[J]. Neuroimage. 2015;122:318-331 doi: 10.1016/j.neuroimage.2015.08.004. [doi]

9. Zhang M, Hu J, Zhang Y, et al. Associations between Aβ deposition and neurometabolic alterations in Alzheimer's disease: Insights from hybrid 3D MRSI‐PET imaging[J]. Alzheimer's & Dementia, 2025, 21(6): e70332. doi: 10.1002/alz.70332. [doi]

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http://echo.ismrm.org/p/ISMRM2026/551-03-013