Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
469-03-015 ISMRM Abstract

Age- and Region-Specific Water Relaxation Atlases for Metabolite Concentration Correction: Comparison of QALAS and DESPOT

Primary: Acquisition & Reconstruction - Quantitative Imaging: relaxometry, multi-parametric, MR Fingerprinting, and synthetic MRI
Secondary: Analysis Methods - Data Processing
469-03-015 · Software and Analysis for MR Spectroscopy and Chemical Shift Imaging · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row J
Keywords: Relaxometry Spectroscopy Atlas Relaxation times
Accepted
Abdelrahman Gad1, Yulu Song1, Gizeaddis Simegn1, Saipavitra Murali-Manohar1, Zahra Shams1, Helge J Zöllner 1, Christopher W Davies-Jenkins1, Dunja Simicic1, Aaron T Gudmundson2, Emily Carter3, Can Ceritoglu4, J Tilak Ratnanather4,5, Vivek Yedavalli1, Georg Oeltzschner1, Borjan Gagoski6,7, Eric C Porges3,8, Richard AE Edden1
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States of America
2The Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, United States of America
3Center for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Clinical and Health Psychology, University of Florida, Gainesville, United States of America
4Center for Imaging Science and Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, United States of America
5F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, United States of America
6Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, United States of America
7Department of Radiology, Harvard Medical School, Boston, United States of America
8Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, United States of America
Presenting Author: Helge J Zöllner

Synopsis

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References

1. Canales-Rodríguez EJ, Alonso-Lana S, Verdolini N, Sarró S, Feria I, Montoro I, Garcia-Ruiz B, Jimenez E, Varo C, Albacete A, Argila-Plaza I, Lluch A, Bonnin CM, Vilella E, Vieta E, Pomarol-Clotet E, Salvador R. Age- and gender-related differences in brain tissue microstructure revealed by multi-component T2 relaxometry. Neurobiol Aging. 2021 Oct;106:68-79. doi: 10.1016/j.neurobiolaging.2021.06.002. Epub 2021 Jun 10. PMID: 34252873. [doi] [pmid]
2. Simegn GL, Gagoski B, Song Y, Dean DC 3rd, Hupfeld KE, Murali-Manohar S, Davies-Jenkins CW, Simičić D, Wisnowski J, Yedavalli V, Gudmundson AT, Zöllner HJ, Oeltzschner G, Edden RAE. Comparison of test-retest reproducibility of DESPOT and 3D-QALAS for water T1 and T2 mapping. bioRxiv [Preprint]. 2024 Aug 19:2024.08.15.608081. doi: 10.1101/2024.08.15.608081. Update in: Quant Imaging Med Surg. 2025 May 1;15(5):3807-3823. doi: 10.21037/qims-24-1870. PMID: 39229114; PMCID: PMC11370424. [doi] [pmid]
3. Ceritoglu C, Tang X, Chow M, Hadjiabadi D, Shah D, Brown T, Burhanullah MH, Trinh H, Hsu JT, Ament KA, Crocetti D, Mori S, Mostofsky SH, Yantis S, Miller MI, Ratnanather JT. Computational analysis of LDDMM for brain mapping. Front Neurosci. 2013 Aug 27;7:151. doi: 10.3389/fnins.2013.00151. PMID: 23986653; PMCID: PMC3753595. [doi] [pmid]
4. Lim IA, Faria AV, Li X, Hsu JT, Airan RD, Mori S, van Zijl PC. Human brain atlas for automated region of interest selection in quantitative susceptibility mapping: application to determine iron content in deep gray matter structures. Neuroimage. 2013 Nov 15;82:449-69. doi: 10.1016/j.neuroimage.2013.05.127. Epub 2013 Jun 12. PMID: 23769915; PMCID: PMC3966481. [doi] [pmid]
5. Ashburner, J., Barnes, G., Chen, C. C., Daunizeau, J., Flandin, G., Friston, K., ... & Penny, W. (2014). SPM12 manual. Wellcome Trust Centre for Neuroimaging, London, UK, 2464(4), 53.
6. Simegn GL, Song Y, Murali-Manohar S, Zöllner HJ, Davies-Jenkins CW, Simicic D, Hupfeld KE, Gudmundson AT, Muska E, Carter E, Hui SCN, Yedavalli V, Oeltzschner G, Dean DC 3rd, Ceritoglu C, Ratnanather JT, Porges E, Edden R. A Water Relaxation Atlas for Age- and Region-Specific Metabolite Concentration Correction at 3 T. NMR Biomed. 2025 Jan;38(1):e5300. doi: 10.1002/nbm.5300. PMID: 39662516; PMCID: PMC12127971. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/469-03-015