Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
462-03-001 ISMRM Abstract

Associations of Cerebral Arterial Pulsatility and Damping with Vascular Dysfunction, Amyloid Pathology, and Cognitive Decline

Primary: Neuro - Blood Vessels
Secondary: Neuro - Dementia
462-03-001 · Heart and Brain Axis · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row C
Keywords: Neurovascular 7T Hemodynamic 2D Phase-contrast MRI Pulsatility
Accepted
Rui Qian1, Jianing Tang 1, Elizabeth Joe2, Helena Chui2, Lirong Yan1
1Radiology, Northwestern University Feinberg School of Medicine, Chicago, United States of America
2Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, United States of America
Presenting Author: Jianing Tang

Synopsis

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References

1. Mitchell, G. F. Arterial Stiffness and Wave Reflection: Biomarkers of Cardiovascular Risk. Artery Res 3, 56–64 (2009). https://doi.org/10.1016/j.artres.2009.02.002 [doi]
2. Geurts, L. J., Zwanenburg, J. J. M., Klijn, C. J. M., Luijten, P. R. & Biessels, G. J. Higher Pulsatility in Cerebral Perforating Arteries in Patients With Small Vessel Disease Related Stroke, a 7T MRI Study. Stroke 50, 62–68 (2019). https://doi.org/10.1161/strokeaha.118.022516 [doi]
3. Tang J, et al. Comparison of arterial pulsatility of cerebral perforating arteries between dual-VENC and single-VENC phase-contrast MRI at 7T. ISMRM 2023. https://archive.ismrm.org/2023/2297.html
4. Rivera-Rivera, L. A. et al. 4D flow MRI for intracranial hemodynamics assessment in Alzheimer’s disease. J Cereb Blood Flow Metab 36, 1718–1730 (2016). https://doi.org/10.1177/0271678X15617171 [doi]
5. Mestre, H. et al. Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nat Commun 9, 4878 (2018). https://doi.org/10.1038/s41467-018-07318-3 [doi]
6. Iturria-Medina, Y. et al. Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis. Nat Commun 7, 11934 (2016). https://doi.org/10.1038/ncomms11934 [doi]
7. Hughes TM, et al. Arterial stiffness and dementia pathology : atherosclerosis risk in communities (ARIC)-PET study. Neurology 2018;90:e1248-e1256. https://doi.org/10.1212/WNL.0000000000005259 [doi]
8. Tarumi T, et al. Amyloid burden and sleep blood pressure in amnestic mild cognitive impairment. Neurology 2015, 85, 1922–1929. https://doi.org/10.1212/WNL.0000000000002167 [doi]

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http://echo.ismrm.org/p/ISMRM2026/462-03-001