Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
503-01-001 ISMRM Abstract

Imaging Cerebral Blood Perfusion and Oxygen Metabolism in Sickle Cell Disease Using Velocity Selective Arterial Spin Labeling

Primary: Neuro - Stroke and Cerebrovascular Disorders
Secondary: Contrast Mechanisms - Arterial Spin Labelling
503-01-001 · Innovative Methods To Understand Stroke · Wednesday, 13 May, 8:20 AM–10:10 AM · Auditorium 1
Accepted
YANHUA CHEN1, Aliyah Alick2, Chenming Pu1, Dan Zhu3,4, Doris Lin 5, Qin Qin3,4, Eboni Lance2,6, Feng Xu5,7
1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, United States of America
2Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, United States of America
3Department of Radiology, University of Washington School of Medicine, SEALLTE, United States of America
4Diagnostic Imaging Sciences Center (DISC), University of Washington School of Medicine, SEALLTE, United States of America
5The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States of America
6Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
7F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, United States of America
Presenting Author: Doris Lin

Synopsis

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References

1. Wang Y, Fellah S, Fields ME, et al. Cerebral Oxygen Metabolic Stress, Microstructural Injury, and Infarction in Adults With Sickle Cell Disease. Neurology. 2021;97(9):e902-e912. doi:10.1212/WNL.0000000000012404 [doi]
2. Jordan LC, Gindville MC, Scott AO, et al. Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia. Brain. 2016;139(Pt 3):738-750. doi:10.1093/brain/awv397 [doi]
3. Watchmaker JM, Juttukonda MR, Davis LT, et al. Hemodynamic mechanisms underlying elevated oxygen extraction fraction (OEF) in moyamoya and sickle cell anemia patients. J Cereb Blood Flow Metab. 2018;38(9):1618-1630. doi:10.1177/0271678X16682509 [doi]
4. Václavů L, Petr J, Petersen ET, et al. Cerebral oxygen metabolism in adults with sickle cell disease. Am J Hematol. 2020;95(4):401-412. doi:10.1002/ajh.25727 [doi]
5. Vu C, Bush A, Choi S, et al. Reduced global cerebral oxygen metabolic rate in sickle cell disease and chronic anemias. Am J Hematol. 2021;96(8):901-913. doi:10.1002/ajh.26203 [doi]
6. Bush AM, Coates TD, Wood JC. Diminished cerebral oxygen extraction and metabolic rate in sickle cell disease using T2 relaxation under spin tagging MRI. Magn Reson Med. 2018;80(1):294-303. doi:10.1002/mrm.27015 [doi]
7. Li W, Xu X, Liu P, et al. Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T2 -based oxygenation calibrations. Magn Reson Med. 2020;83(3):1066-1080. doi:10.1002/mrm.27972 [doi]
8. Juttukonda MR, Donahue MJ, Davis LT, et al. Preliminary evidence for cerebral capillary shunting in adults with sickle cell anemia. J Cereb Blood Flow Metab. 2019;39(6):1099-1110. doi:10.1177/0271678X17746808 [doi]
9. Lin Z, McIntyre T, Jiang D, et al. Brain Oxygen Extraction and Metabolism in Pediatric Patients With Sickle Cell Disease: Comparison of Four Calibration Models. Front Physiol. 2022;13:814979. doi:10.3389/fphys.2022.814979 [doi]
10. Fellah S, Ying C, Wang Y, et al. Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls. J Cereb Blood Flow Metab. 2024;44(8):1404-1416. doi:10.1177/0271678X241237072 [doi]
11. Bush A, Borzage M, Detterich J, et al. Empirical model of human blood transverse relaxation at 3 T improves MRI T2 oximetry. Magn Reson Med. 2017;77(6):2364-2371. doi:10.1002/mrm.26311 [doi]
12. Bush A, Vu C, Choi S, et al. Calibration of T2 oximetry MRI for subjects with sickle cell disease. Magn Reson Med. 2021;86(2):1019-1028. doi:10.1002/mrm.28757 [doi]
13. Qin Q, van Zijl PCM. Velocity-selective-inversion prepared arterial spin labeling. Magn Reson Med. 2016;76(4):1136-1148. doi:10.1002/mrm.26010 [doi]
14. Qin Q, Qu Y, Li W, et al. Cerebral blood volume mapping using Fourier-transform-based velocity-selective saturation pulse trains. Magn Reson Med. 2019;81(6):3544-3554. doi:10.1002/mrm.27668 [doi]
15. Li W, Liu D, van Zijl PCM, Qin Q. Three-dimensional whole-brain mapping of cerebral blood volume and venous cerebral blood volume using Fourier transform-based velocity-selective pulse trains. Magn Reson Med. 2021;86(3):1420-1433. doi:10.1002/mrm.28815 [doi]
16. Qin Q, Strouse JJ, van Zijl PCM. Fast measurement of blood T1 in the human jugular vein at 3 Tesla. Magn Reson Med. 2011;65(5):1297-1304. doi:10.1002/mrm.22723 [doi]
17. Qin Q, Grgac K, van Zijl PCM. Determination of whole-brain oxygen extraction fractions by fast measurement of blood T(2) in the jugular vein. Magn Reson Med. 2011;65(2):471-479. doi:10.1002/mrm.22556 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/503-01-001