Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
363-01-013 ISMRM Abstract

Along-the-Tract Analysis to Characterize White Matter Microstructural Changes in Acute Sport-Related Concussion

Primary: Diffusion - Diffusion Analysis & Visualization
Secondary: Neuro - Traumatic Brain Injury
363-01-013 · Neurological Application of Advanced Diffusion and Quantitative MRI · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row D
Keywords: Mild Traumatic Brain Injury Diffusion MRI Sport-related concussion TRACULA Tract-specific analysis
Accepted
Tayyebeh Ebrahimi1, Syed Salman Shahid1, Ho-Ching Yang1, Timothy B Meier2, Sujuan Gao3, Jaroslaw Harezlak4, Christopher C Giza5, Joshua Goldman6, Kevin M Guskiewicz7, Jason P Mihalik8, Stephen M LaConte9, Stefan M Duma10, Andrew J Saykin1, Steven P Broglio11, Michael A McCrea12, Thomas W McAllister13, Yu-Chien Wu 1
1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, United States of America
2Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, United States of America
3Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, United States of America
4Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, United States of America
5Departments of Neurosurgery and Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, United States of America
6Family Medicine, Ronald Reagan UCLA Medical Center, UCLA Health, Los Angeles, United States of America
7Office of the President, Michigan State University, East Lansing, United States of America
8Department of Exercise and Sport Science, Matthew Gfeller Center, University of North Carolina at Chapel Hill, United States of America
9School of Biomedical Engineering and Sciences, Wake-Forest and Virginia Tech University, Virginia Tech Carilion Research Institute, Roanoke, United States of America
10School of Biomedical Engineering and Sciences, Wake-Forest and Virginia Tech University,Virginia Tech 313 Kelly Hall, Blacksburg, United States of America
11Michigan Concussion Center, University of Michigan, Ann Arbor, United States of America
12Medical College of Wisconsin, Milwaukee, United States of America
13Department of Psychiatry, Indiana University School of Medicine, Indianapolis, United States of America
Presenting Author: Yu-Chien Wu

Synopsis

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References

1. Zhang H, Schneider T, Wheeler-Kingshott CA, Alexander DC. NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. Neuroimage. 2012;61(4):1000-16.
2. Li F, Huang XQ, Yang YC, Li B, Wu QZ, Zhang TJ, et al. Microstructural Brain Abnormalities in Patients with Obsessive-Compulsive Disorder: Diffusion-Tensor MR Imaging Study at 3.0 T. Radiology. 2011;260(1):216-23.
3. Fan Q, Yan X, Wang JJ, Chen Y, Wang XM, Li CB, et al. Abnormalities of White Matter Microstructure in Unmedicated Obsessive-Compulsive Disorder and Changes after Medication. Plos One. 2012;7(4).
4. Benedetti F, Giacosa C, Radaelli D, Poletti S, Pozzi E, Dallaspezia S, et al. Widespread changes of white matter microstructure in obsessive-compulsive disorder: Effect of drug status. Eur Neuropsychopharm. 2013;23(7):581-93.
5. Mustafi SM, Harezlak J, Koch KM, Nencka AS, Meier TB, West JD, et al. Acute White-Matter Abnormalities in Sports-Related Concussion: A Diffusion Tensor Imaging Study from the NCAA-DoD CARE Consortium. J Neurotraum. 2018;35(22):2653-64.
6. O'Donnell LJ, Pasternak O. Does diffusion MRI tell us anything about the white matter? An overview of methods and pitfalls. Schizophr Res. 2015;161(1):133-41.
7. Yendiki A, Panneck P, Srinivasan P, Stevens A, Zollei L, Augustinack J, et al. Automated probabilistic reconstruction of white-matter pathways in health and disease using an atlas of the underlying anatomy. Front Neuroinform. 2011;5:23.
8. Jang SH, Lee HD. Diagnostic Approach to Traumatic Axonal Injury of the Spinothalamic Tract in Individual Patients with Mild Traumatic Brain Injury. Diagnostics. 2019;9(4).
9. Broglio SP, McCrea M, McAllister T, Harezlak J, Katz B, Hack D, et al. A National Study on the Effects of Concussion in Collegiate Athletes and US Military Service Academy Members: The NCAA-DoD Concussion Assessment, Research and Education (CARE) Consortium Structure and Methods. Sports Med. 2017;47(7):1437-51.
10. Behrens TE, Berg HJ, Jbabdi S, Rushworth MF, Woolrich MW. Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? Neuroimage. 2007;34(1):144-55.
11. Ahrens J, Geveci B, Law C, Hansen C, Johnson C. ParaView: An end-user tool for large-data visualization. The visualization handbook. Elsevier. 2005;717:50038-1.
12. Bigler ED. Neuropsychology and clinical neuroscience of persistent post-concussive syndrome. J Int Neuropsych Soc. 2008;14(1):1-22.
13. Budde MD, Janes L, Gold E, Turtzo LC, Frank JA. The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections. Brain. 2011;134:2248-60.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/363-01-013