Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
503-01-004 ISMRM Abstract

Evaluation of Cerebral Oxygen Metabolism in Patients with Carotid Steno-occlusive Disease by 3D Constrained Quantitative BOLD

Primary: Neuro - Stroke and Cerebrovascular Disorders
Secondary: Brain Function and fMRI - fMRI Analysis
503-01-004 · Innovative Methods To Understand Stroke · Wednesday, 13 May, 8:20 AM–10:10 AM · Auditorium 1
Keywords: Oxygen extraction fraction Quantitative BOLD Quantitative Susceptibility Mapping (QSM) Cerebral Oxygen Metabolism Steno occlusive disease
Accepted
Kathryn Jaroszynski 1,2, Jeffrey B Dennison1, Christopher G Favilla3, Hyunyeol Lee1,4, Felix W Wehrli1
1Department of Radiology, University of Pennsylvania, Philadelphia, United States of America
2Department of Bioengineering, University of Pennsylvania, Philadelphia, United States of America
3Department of Neurology, University of Pennsylvania, Philadelphia, United States of America
4Kyungpook National University, Daegu, Korea, Republic of
Presenting Author: Kathryn Jaroszynski

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References

1. 1. Rodgers ZB, Detre JA, Wehrli FW. MRI-based methods for quantification of the cerebral metabolic rate of oxygen. J Cereb Blood Flow Metab. Jul 2016;36(7):1165-85. doi:10.1177/0271678X16643090 [doi]
2. 2. Cui B, Zhang T, Ma Y, et al. Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease. Eur J Nucl Med Mol Imaging. Jul 2020;47(7):1668-1677. doi:10.1007/s00259-019-04551-w [doi]
3. 3. Gottler J, Kaczmarz S, Kallmayer M, et al. Flow-metabolism uncoupling in patients with asymptomatic unilateral carotid artery stenosis assessed by multi-modal magnetic resonance imaging. J Cereb Blood Flow Metab. Nov 2019;39(11):2132-2143. doi:10.1177/0271678X18783369 [doi]
4. 4. Gupta A, Baradaran H, Schweitzer AD, et al. Oxygen extraction fraction and stroke risk in patients with carotid stenosis or occlusion: a systematic review and meta-analysis. AJNR Am J Neuroradiol. Feb 2014;35(2):250-5. doi:10.3174/ajnr.A3668 [doi]
5. 5. van Laar PJ, van der Grond J, Bremmer JP, Klijn CJ, Hendrikse J. Assessment of the contribution of the external carotid artery to brain perfusion in patients with internal carotid artery occlusion. Stroke. Nov 2008;39(11):3003-8. doi:10.1161/STROKEAHA.108.514265 [doi]
6. 6. Jaroszynski KM, Lee, H., Langham, M.C., Wehrli, F.W. Comparison of brain oxygen metabolic parameters between constrained qBOLD and whole-brain oximetric methods at baseline and in response to a physiologic stimulus. NMR in Biomedicine. 2025;doi:10.1002/nbm.70120 [doi]
7. 7. Lee H, Wehrli FW. Whole-brain 3D mapping of oxygen metabolism using constrained quantitative BOLD. Neuroimage. Apr 15 2022;250:118952. doi:10.1016/j.neuroimage.2022.118952 [doi]
8. 8. Lee H, Xu J, Fernandez-Seara MA, Wehrli FW. Validation of a new 3D quantitative BOLD based cerebral oxygen extraction mapping. J Cereb Blood Flow Metab. Jan 30 2024;44(7):1184-1198. doi:10.1177/0271678X231220332 [doi]
9. 9. Xu F, Ge Y, Lu H. Noninvasive quantification of whole-brain cerebral metabolic rate of oxygen (CMRO2) by MRI. Magn Reson Med. Jul 2009;62(1):141-8. doi:10.1002/mrm.21994 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/503-01-004