Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
502-03-010 ISMRM Abstract

Quantification of White Matter Perivascular Spaces in Children with Autism Spectrum Disorder and Healthy Controls Using WPSS

Primary: Neuro - Neurofluids
Secondary: Pediatrics - Neuro
502-03-010 · Defining "Normal" in Pediatric Brain MRI · Wednesday, 13 May, 1:40 PM–3:30 PM · Hall 1B
Keywords: Glymphatics Pediatric Neurofluids Deep Learning Segmentation Brain MRI
Accepted
Chiara Girardi 1, Denis Peruzzo2, Francesca Castellotti1, Elisa Mani3, Fabiola Lanteri3, Valentina Mariani3, Nivedita Agarwal1
1Neuroradiology Unit, Scientific Insitute IRCCS Eugenio Medea, Bosisio Parini (LC), Italy
2Neuroimaging Lab, Scientific Insitute IRCCS Eugenio Medea, Bosisio Parini (LC), Italy
3Child Psychopathology Unit, Scientific Insitute IRCCS Eugenio Medea, Bosisio Parini (LC), Italy
Presenting Author: Chiara Girardi

Synopsis

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References

1. Garic D, McKinstry RC, Rutsohn J, et al. Enlarged Perivascular Spaces in Infancy and Autism Diagnosis, Cerebrospinal Fluid Volume, and Later Sleep Problems. JAMA Netw Open. 2023;6(12):E2348341. doi:10.1001/jamanetworkopen.2023.48341 [doi]
2. Sotgiu S, Cavassa V, Puci MV, et al. Enlarged perivascular spaces under the dorso-lateral prefrontal cortex and severity of autism. Sci Rep. 2025;15(1):8142. doi:10.1038/s41598-025-92913-w [doi]
3. Lan H, Lynch KM, Custer R, et al. Weakly supervised perivascular spaces segmentation with salient guidance of Frangi filter. Magn Reson Med. 2023;89(6):2419-2431. doi:10.1002/mrm.29593 [doi]
4. Frigerio G, Rizzato G, Peruzzo D, et al. Perivascular Space Burden in Children With Autism Spectrum Disorder Correlates With Neurodevelopmental Severity. J Magn Reson Imaging. Published online 2025:1-11. doi:10.1002/jmri.70023 [doi]
5. Lee JK, Andrews DS, Ozonoff S, et al. Longitudinal Evaluation of Cerebral Growth Across Childhood in Boys and Girls With Autism Spectrum Disorder. Biol Psychiatry. 2021;90(5):286-294. doi:10.1016/j.biopsych.2020.10.014 [doi]
6. Shen MD, Ph D, Kim SH, et al. Increased Extra-axial Cerebrospinal Fluid in High-Risk Infants Who Later Develop Autism. Biol Psychiatry. 2018;82(3):186-193. doi:10.1016/j.biopsych.2017.02.1095.Increased [doi]

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http://echo.ismrm.org/p/ISMRM2026/502-03-010