Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition • 09-14 May 2026

Digital Poster

Segmentation for Neuro Applications

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Segmentation for Neuro Applications
Digital Poster
Analysis Methods
Wednesday, 13 May 2026
Digital Posters Row E
16:55 - 17:50
Session Number: 564-06
No CME/CE Credit
This digital poster session features advanced work on segmentation in MRI, with a strong emphasis on neuroanatomical structures, brain pathologies, and methodological robustness. The abstracts cover a wide range of applications including deep brain nuclei, white-matter tracts, cerebellar and thalamic structures, tumors, stroke, vascular anatomy, and functional speech imaging. Methodological themes include multi-sequence learning, physics-informed modeling, contrast translation, failure detection, privacy-preserving preprocessing, and diffusion-based segmentation. These Abstracts highlight the diversity and maturity of contemporary segmentation research in brain and head-and-neck MRI, with a clear trajectory toward reliable clinical and intraoperative deployment.
Skill Level: Basic

  Figure 564-06-001.  Multi-Sequence Learning Improves Robustness and Accuracy of Substantia Nigra Segmentation in Neuromelanin-Sensitive MRI
Oliver Welsh, Kilian Hett, Anna Bosman, Daniel Claassen, Paula Trujillo
University of Pretoria, Pretoria, South Africa
Impact: Our multi-sequence training and custom preprocessing pipeline significantly improves segmentation robustness on unseen sequence types. This emphasises the importance of heterogeneous data for training deep-learning models and advancing the clinical scalability of NM-MRI-based neurodegenerative disease assessment.
  Figure 564-06-002.  Fast and Reliable Failure Detection for Image Segmentation Using Pairwise Dice Similarity
Tommaso Di Noto, Ian Cherabier, Lina Bacha, Punith Bidarakka Venkategowda, Keerthi Prabhu M, Silvia Pistocchi, Vincent Dunet, Attapon Jantarato, Manuela Vaneckova, Emmanuelle Le Bars, Jeremy Deverdun, Nicolas Menjot de Champfleur, Jonathan Disselhorst, Bénédicte Maréchal
Siemens Healthineers International AG, Lausanne, Switzerland
Impact: This work helps improve the safety and reliability of AI in medical image segmentation by detecting when results may be inaccurate, supporting better patient care and building trust in automated tools for healthcare professionals and patients.
  Figure 564-06-003.  UltimateSynth Deep-brain Net (UDN): Deep Brain Segmentation of Any MRI Contrast and Age via Physics-Informed Deep Learning
Rhea Adams, Khoi Huynh, Walter Zhao, Zhicheng Wu, Eunate Alzaga Goñi, Hengji Chen, Angela Noecker, Andreas Seas, Benjamin Succop Jr, Stephen Harward II, Cameron McIntyre, Pew-Thian Yap, Dan Ma
Case Western Reserve University, Cleveland, United States of America
Impact: UDN is the first tool to segment clinically relevant deep-brain structures in one minute across all MR contrast types, and is also the first to do so across the entire human lifespan, including both healthy and pathological data.
  Figure 564-06-004.  nnU-Net for automatic segmentation of the parasagittal dura in autistic children using 3D T2-FLAIR
Francesca Castellotti, Nivedita Agarwal, Ruth O'Gorman Tuura, Raimund Kottke, Chiara Girardi, Tommaso Ciceri
Scientific Insitute IRCCS Eugenio Medea, Bosisio Parini (LC), Italy
Impact: This study provides a tool for automatic segmentation and quantification of the parasagittal dura in children with autism spectrum disorder to advance the understanding of its role in neurodevelopmental and neuroinflammatory processes.
  Figure 564-06-005.  OMT and tensor SVD based deep learning model for segmentation and predicting genetic markers of glioma: a multicenter study
Zhengyang Zhu, Han Wang, Huiquan Yang, Yang Song, Mengying Xu, Xin Zhang, Bing Zhang
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
Impact: Accurate characterization of glioma is essential for effective clinical decision-making. Most current studies involve a limited number of patients. This research introduces a novel deep learning model based on OMT to predict molecular markers using international multicenter datasets.
  Figure 564-06-006.  Cross-Domain Transfer Learning and Comparative Analysis of U-Net Architectures for Head and Neck Tumor Segmentation
Khushi Singh, Sourav Basak, Sankar Misra, Subhanon Bera, Sourav Bhaduri
St. Xavier’s College (Autonomous), Kolkata, India
Impact: The study demonstrates that nn-U-Net-architecture can be reliable during the segmentation of head and neck tumor MRI data, and transfer learning may be used to generalize brain tumor segmentation to Head and neck tumor segmentation.
  Figure 564-06-007.  MRI contrast translation for full-brain segmentation from T2-weighted contrasts
Sebastian Rassmann, David Kügler, Martin Reuter
German Center for Neurodegenerative Diseases (DZNE e.V.), Bonn, Germany
Impact: 
We establish an image translation predicting high-quality T1w from T2w or FLAIR images. This enables accurate full-brain segmentation using FastSurfer without requiring T1w acquisition.
  Figure 564-06-008.  Balancing Privacy and Utility in Brain MRI: Effects of Invasive vs. Geometry-Preserving Defacing Methods
Yuli Wang, Yuwei Dai, Haoyue Guan, Cheng-Yi Li, Vora Maulik, Danica Cecil, Ayon Nandi, Jing Wu, Paul Zhang, Justin Honce, Chengzhang Zhu, Haris Sair, Leonora Balaj, Zhicheng Jiao, Yaou Liu, Cheng Tin Lin, Ihab Kamel, Li Yang, Harrison Bai
Johns Hopkins University School of Medicine, Baltimore, United States of America
Impact: Invasive defacing degrades segmentation, Evans-ratio reliability, and VLM reasoning, while geometry-preserving defacing maintains near-baseline performance. These results provide immediate guidance for repositories and labs to satisfy privacy mandates without sacrificing clinical or research utility.
  Figure 564-06-009.  Segmentation of thalamic nuclei from Local Diffusion MRI Features: a comparison of clustering schemes
Debottama Das, Ali Bilgin, manojkumar saranathan
University of Arizona, Tucson, United States of America
Impact: This study advances diffusion-based thalamic segmentation by systematically comparing MSMT-CSD and NODDI features across clustering algorithms, improving hemispheric consistency and establishing a reproducible framework that enhances the reliability and interpretability of thalamic parcellation for future neuroimaging analyses.
  Figure 564-06-010.  2D U-Net Segmentation of Multi-target Deep Brain Stimulation Lead Trajectories on Postoperative Imaging
Eric Cito, Jacob Ellison, Anoushka Shah, Samantha Chan, Naomi Gong, Skyler Deutsch, Sarah Wang, Jill Ostrem, Janine Lupo, Melanie Morrison
University of California San Francisco, San Francisco, United States of America
Impact: No reliable open-source tools exist to segment deep brain stimulation lead trajectories. Leveraging deep learning to achieve fast yet reliable segmentation, our tool can be applied widely to inform surgical targeting strategies and to better understand variance in clinical outcomes.
  Figure 564-06-011.  Intraoperative fast fibre tract segmentation in paediatric tumour patients
Dana Kanel, Fiona Young, Kiran Seunarine, Nikhita Nandi, Annemarie Knill, Enrico De Vita, Kshitij Mankad, Chris Clark, Kristian Aquilina, Jonathan Clayden
University College London, London, United Kingdom
Impact: Tractfinder offers a clinical alternative to tractography for segmenting white matter tracts in tumour patients. It requires minimal processing time and expertise while accounting for tract displacement from space-occupying lesions, with potential to improve tract segmentation methods in clinical practice.
  Figure 564-06-012.  Deep Learning-Based Segmentation of Cerebellar Peduncles Using Diffusion MRI
Soumen Ghosh, Susmita Saha, Diogo Shiraishi, Thiago Rezende, Ian Harding, TRACK-FA Neuroimaging Consortium
The University of Queensland, Brisbane, Australia
Impact: This framework provides a robust automated segmentation of the cerebellar peduncles, enabling reproducible imaging biomarkers for disease monitoring and clinical trials. Its strong intra-cohort performance highlights its potential for future generalization across cerebellar degeneration datasets.
  Figure 564-06-013.  Deep Learning for Automated Meningioma Segmentation: Toward Clinical Integration and Workflow Efficiency
Laxmi Muralidharan, James Ruffle, Ebru Fenney, Anand Pandit, Hani Marcus, Parashkev Nachev, Harpreet Hyare
University College London, London, United Kingdom
Impact: A fully automated deep learning approach enables accurate, reproducible meningioma segmentation, outperforming existing methods. This technology offers substantial potential to standardise volumetric analysis and streamline radiological workflows, improving consistency, efficiency, and decision-making in clinical neuroimaging.
  Figure 564-06-014.  Development and Validation of Automated Intracranial Vessel Segmentation Based on a Heterogeneous MR Angiography Dataset
Pei-Hsuan Kuo, Wei-Chen Chen, Shih-Pin Chen, Chia-Hung Wu, Jiing-Feng Lirng, Shuu-Jiun Wang, Chia-Feng Lu
National Yang Ming Chiao Tung University, Taipei, Taiwan
Impact: This study developed an automated vessel segmentation model for intracranial arteries with satisfactory generalizability across different scanner types and cerebrovascular conditions. The proposed model could detect longitudinal changes in cerebrovascular diseases.
  Figure 564-06-015.  High-Resolution 4D Speech MRI using Compressed Sensing and Deep Learning Segmentation
Eric Schrauben, Roos Boekema, Lisette van der Molen, Ludwig Smeele, Engelbert AJM Schulten, Aart Nederveen
Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
Impact: Tongue function is critical for speech and swallowing, yet current 2D or low-resolution 3D imaging limits assessment. Our approach enables high-resolution visualization of vocal tract dynamics, with the future goal of identifying functional impairments and guiding targeted speech therapy strategies.
  Figure 564-06-016.  Automated White Matter Lesion Detection Among People Living with HIV: A Preliminary Analysis
Sophia Wang, Yannan Yu, David Saloner, Felicia Chow, Jared Narvid
UCSF, San Francisco, United States of America
Impact: Patients with HIV have a greater burden and severity of small vessel disease. In these populations, quantitative WMH assessment can provide a reliable representation for lesion severity, offering more granular data on clinical monitoring currently described with the Fazekas score.

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