Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition • 09-14 May 2026
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465-06-001.
Evaluation of Ultra-high b-value diffusion MRI on the NexGen 7T scanner with high-performance head gradients
Impact: The cumulative gains in SNR offered by ultra-high field, coupled with high-performance gradients, enable ultra-high b-values (up to 40,000 s/mm2) in diffusion brain imaging, a benefit to brain microstructure analysis that may resolve changes in neurological diseases.
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465-06-002.
High-fidelity 3D dMRI using Slab-shifted Harmonization Acquisition and Reconstruction with Profile Encoding Network (SHARPEN)
Impact: We present a method that improves the image quality for high-resolution
3D multi-slab diffusion MRI. We demonstrate high-fidelity submillimeter diffusion
MRI with potential to provide more fine-grained depictions of human brain microstructure and
connectivity.
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465-06-003.
Diffusion relaxometry in a clinical time frame
Impact: This study presents a fast diffusion relaxometry sequence combining DWI with multiple inversion and echo times, enabling selective tissue nulling of CSF, gray matter, and white matter. It supports multidimensional tissue characterization within clinically feasible scan durations.
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465-06-004.
Single-shot MOLED delivers rapid T2+ADC mapping for preoperative typing of meningioma, glioma, and schwannoma
Impact: Single-shot MQMOLED delivers rapid, registration-free, multiparametric maps that enhance preoperative differentiation of meningioma, glioma, and schwannoma, supporting individualized planning and reducing dependence on longer, multi-sequence workflows.
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465-06-005.
Optimized gradient waveforms for isotropic diffusion and restriction weighting via double-isotropic matched encoding (DIME)
Impact: Our design reduces diffusion-time bias, enabling more accurate parameter estimation and interpretation for models that omits such effects. It is optimizable for target MRI hardware and includes explicit control of concomitant gradient effects and nerve-stimulation, improving usability and safety.
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465-06-006.
Simultaneous measurement of glutamate and lactate and quantification of creatine diffusion with optimised DW-MRS protocol
Impact: Optimised protocol for
functional diffusion-weighted MRS maximizes measurement accuracy for simultaneous
evaluation of neurometabolite concentrations and diffusion changes, providing a
holistic picture of neurotransmission, metabolic and microstructural changes
associated with neuronal activity.
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465-06-007.
Eddy current pre‐compensation gradients design for diffusion preparation
Impact: Numerically optimized pre-compensation gradients
(PreENCODE) mitigate eddy-current–induced signal loss in diffusion-prepared
imaging without additional hardware or scan time. In phantom and brain,
PreENCODE successfully reduced eddy currents for 2RFE and 3RFE preparations.
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465-06-008.
Optimized Slice-specific Shimming of Whole-body DWI in High-BMI Subjects
Impact: Substantial improvements in fat suppression and diagnostic image quality in whole-body DWI of high-BMI subjects were achieved using a data-guided slice-specific shimming optimization, demonstrating the feasibility of this technique in challenging clinical conditions where conventional volumetric shimming often fails.
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465-06-009.
Non-CPMG diffusion-weighted turbo spin-echo imaging
Impact: A non-CPMG TSE echo train is measured at short TE and data reconstructed using a matrix inversion approach. Compared to the standard implementation sensitivity is improved by more than a factor more than 2.5 offering improved diagnosis and broader utilisation.
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465-06-010.
Direction-interleaved spirals for direct estimation of mean diffusion-weighted images
Impact: Direction-interleaved spirals provide
an approach for direct estimation of mean diffusion at sub-mm resolution, which has a wide array of applications, from oncological screening to IVIM. This
proof of concept motivates further investigation and validation of the obtained
contrast.
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465-06-011.
CL+μGUIDE: Posterior-Guided Sequence Optimisation for Multidimensional MRI
Impact: Our Machine Learning–based optimisation method enables subselection of multidimensional MRI measurements using posterior distributions, preserving parameter estimation accuracy with five-fold fewer acquisitions. This posterior-guided framework improves protocol design, reducing acquisition time without compromising fidelity.
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465-06-012.
Diffusion MRI with high spatial resolution and high b-values on a clinical 7T MRI scanner with enhanced gradient capabilities
Impact: We leverage stronger gradients on a clinical 7T scanner (Siemens
Terra.X) to further increase the spatial and angular resolution of the 7T HCP
diffusion protocol, closing any gaps with diffusion imaging on modern clinical
3T scanners.
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465-06-013.
Deep Probabilistic Multishell Undersampling for Diffusion Spectrum Imaging
Impact: The proposed Deep Probabilistic Multishell Undersampling (DPMU)
framework learns microstructure-specific optimal sampling patterns,
significantly reducing scan time while preserving the accuracy of microstructure
mapping.
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465-06-014.
Single-Slab 3D Brain DWI with Motion-Compensated Diffusion Encoding: Repeatability and SNR Evaluation
Impact: Higher-order motion-compensated diffusion encoding
enables stable, single-slab 3D-DWI with reduced ghosting and anticipated SNR.
The technique can advance diffusion MRI methodology, potentially facilitating
high-resolution, reproducible imaging for better lesion detection and more
detailed quantitative microstructural analysis.
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465-06-015.
Optimized Experimental Design for In Vivo SANDI Microstructural Imaging with Ultra-Strong Gradient Diffusion MRI
Impact: Diffusion MRI requires long scan times and high energy due to complex
protocols. We applied the TADRED
framework for joint acquisition optimization and parameter
estimation, outperforming typical approaches. TADRED can facilitate efficient, information-rich dMRI acquisitions for clinical and research use.
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465-06-016.
Comparative Evaluation of Orbital DWI Image Quality Using RESOLVE, EPI, and ZOOMit Techniques
Impact: Under strictly controlled conditions (i.e., identical scan times), the performance of three DWI sequences was evaluated for orbital imaging. Compared to other sequences, RESOLVE provided superior image quality for diagnosis, with less distortion, sharper edges, and higher tissue contrast.
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