Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition • 09-14 May 2026

Digital Poster

Multimodal Acquisitions for Brain Function Studies

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Multimodal Acquisitions for Brain Function Studies
Digital Poster
Brain Function & fMRI
Tuesday, 12 May 2026
Digital Posters Row B
16:55 - 17:50
Session Number: 461-06
No CME/CE Credit
multi-modal studies of brain function, using different techniques and approaches in healthy brains and disease
Skill Level: Basic

  Figure 461-06-001.  Simultaneous gas-free calibrated fMRI and fNIRS measurements in human visual cortex: a feasibility study
Giulia Rocco, Lucie Chalet, Sara Pomante, Elizabeth Fear, Francesca Graziano, Davide Di Censo, Manuela Carriero, David Perpetuini, Cosimo Del Gratta, Mauro Gianni Perrucci, Richard Wise, Antonio Chiarelli
University 'G.d'Annunzio' of Chieti-Pescara, Chieti, Italy
Impact: The combined gas-free calibrated fMRI and fNIRS approach enhances the physiological interpretability of metabolic mapping, providing a validated basis for multimodal fusion models and future studies of altered neurovascular coupling in patient populations.
  Figure 461-06-002.  Functional MRI compatible simultaneous cortical wide-field fluorescent Ca2+ and intrinsic oxy/deoxy-hemoglobin imaging
Taekyung Kang, Francesca Mandino, Nicole Allen, Omer Mano, Paul Shamble, Joel Greenwood, Evelyn Lake
Yale University, New Haven, United States of America
Impact: Simultaneous wide-field Ca2+ and fMRI provides two complementary measures of spontaneous brain activity across the mouse cortex. Yet, bridging these measures has proven challenging. The addition of oxy/deoxy-hemoglobin imaging stands to better our understanding of neurovascular coupling within brain networks.
  Figure 461-06-003.  Simultaneous BOLD and ASL-based cerebrovascular reactivity mapping and their relationship with baseline cerebral blood flow
Catarina Domingos, Inés Chavarría, Patricia Figueiredo, César Caballero-Gaudes
Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal
Impact: Our work shows that BOLD-based CVR is confounded by baseline cerebral blood volume and cerebral blood flow, in contrast to Arterial Spin Labelling, hence this should be used to obtain a more reliable estimation of CVR.
  Figure 461-06-004.  Functional PET-MRI reveals flow-metabolism uncoupling and altered aerobic glycolysis in default network during working memory
Shirley Feng, Sean Coursey, Meher Juttukonda, Jennifer Evans, Avery Berman, Kyle Droppa, Jonathan Polimeni, Bruce Rosen, Ovidiu Andronesi, Jingyuan Chen
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
Impact: These findings reveal complex physiological dynamics of the default-mode network under cognitive load, offering insight into disrupted DMN deactivations in mental illness and underscoring the need to revisit assumptions about brain physiology underlying fMRI deactivation.
  Figure 461-06-005.  Functional Electrical Properties Tomography with Simultaneous BOLD fMRI – Null Results with a Visual Task Using GLM and ICA
Jierong Luo, Karin Shmueli
University College London, London, United Kingdom
Impact: We showed that visual task-based fEPT gave null results similar to those from a task-free reference acquisition and inconsistent with simultaneous BOLD-fMRI. This first ICA of task-based fEPT shows that caution is needed with biophysical interpretation of fEPT results.
  Figure 461-06-006.  Multi-echo ASL-BOLD fMRI reveals attenuated inhibitory-control activation following mental fatigue
Manon Roose, Bart Roelands, Maarten Naeyaert, Hubert Raeymaekers, PETER VAN SCHUERBEEK
Vrije Universiteit Brussel, Brussels, Belgium
Impact: Multi-echo ASL-BOLD fMRI enables detection of neural alterations in inhibitory control following mental fatigue, advancing understanding of its impact on cognitive efficiency and providing an approach to assess fatigue-related performance decline.
  Figure 461-06-007.  High-resolution mapping of TMS-induced BOLD responses to motor cortex stimulation across the whole brain using the RF Cap.
Lucia Navarro de Lara, Evgenii Kim, Danyal Bhutto, Mohammad Daneshzand, Aapo Nummenmaa
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
Impact: We present full brain concurrent TMS/fMRI over motor cortex using a dedicated wearable 26-channel head RF coil array, the RF Cap. Results show high temporal and spatial resolution of TMS effects, even at subthreshold stimulation intensities with no muscle activation.
  Figure 461-06-008.  Evaluating the Sensitivity Limit of 3 T Spin-Lock fMRI for Detecting Alpha Oscillations in the Human Brain
Yannick Robert, Roland Wiest, Jessica Bastiaansen, Milena Capiglioni
University of Bern, Bern, Switzerland
Impact: Spin-Lock fMRI has the potential for direct mapping of oscillatory neuronal activity, yet the in vivo sensitivity remains a challenge. This study shows a practical sensitivity limit of 1.5 nT, based on noise level differences in spin-lock and BOLD acquisitions.
  Figure 461-06-009.  Feasibility of a wearable, inductively-coupled 7-channel RF receive array for concurrent 3T TMS/fMRI
Zi Xiong, Jason Stockmann, Lawrence Wald, Aapo Nummenmaa, Lucia Navarro de Lara
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
Impact: We show a flexible, form-fitting, low-cost “RF-Light” receive array for concurrent TMS-MRI scans. The RF-Light is inductively-coupled to remotely-positioned vendor receive array coils, opening up space close to the head and providing full freedom for TMS coil positioning.
  Figure 461-06-010.  Hippocampal connectivity in schizophrenia: a comparison of DASL and BOLD fMRI
Yakun Zhang, Shichun Chen, Jinnat Mahmood, Darcy Miller, Xiang He, Jodi Weinstein, Weiying Dai
The State University of New York at Binghamton, Binghamton, United States of America
Impact: Dynamic ASL (DASL) is more sensitive than BOLD in detecting alterations of hippocampal resting state functional connectivity in schizophrenia. If replicated, these findings could provide new leads into hippocampal dysfunction in schizophrenia, suggesting that DASL adds value for clinical neuroimaging.
  Figure 461-06-011.  Simultaneous two-voxel fMRS and fMRI of the motor cortex at 7T
Anouk Schrantee, Thea Naue, Sara Monteiro, William Clarke, Adam Berrington
Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
Impact: This work validates a two-voxel interleaved fMRS–fMRI protocol at 7T, enabling simultaneous measurement of bilateral neurometabolic and BOLD changes during unilateral movement. The approach paves the way for future studies of interhemispheric coordination and excitation–inhibition dynamics in distributed cortical networks.
  Figure 461-06-012.  Multimodal Imaging of the cingulate cortex in Parkinson's Disease: Implications for Cognitive and Depression
Wei Su, qichao cheng, Feng Xue, Jiaxiang xin, Qianwen Zhang, Xuan Li, LingYang Zeng, Zhengqi Zhu, Chunming Gu, Kaihua Zhang
Shandong Normal University, Jinan, China
Impact: This study highlights altered brain activity, impaired metabolism, and neurochemical imbalances in PD patients, providing insights into cognitive decline and depressive symptoms, potentially guiding early biomarkers and therapeutic strategies.
  Figure 461-06-013.  Assessing the Impact of Aerobic Exercise Capacity on Cerebral Metabolism and Glymphatic Function in Aging by PET-MRI
Anbang Chen, Junqing Zhu, Yuran Zhu, Chunying Wu, Chenxin Ni, Darcy Chew, Daniel Deng, Steven Britton, Lijing Xin, Lauren Koch, Xin Yu
Case Western Reserve University, Cleveland, United States of America
Impact: 
This study reveals that improving aerobic exercise capacity promotes brain health by improving brain metabolism, preserving cerebrovascular integrity, and normalizing waste clearance. These results underscore exercise’s potential to preserve cerebral function and mitigate neurodegenerative processes associated with aging.

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