Impact: This study provides a novel perspective on the destructing effect of PSD on individual’s brain dymamics that may jeopardize the professional excellence, and informed the potential utility of brain criticality metrics for the treatment response assessment of neuro behavioral therapy.

Impact: This study highlights shared and distinct brain alterations in schizophrenia and obesity, emphasizing the insula’s key role. These findings may guide future research on metabolic–neural mechanisms and inform targeted interventions for obesity prevention in schizophrenia.

Impact: For the first time, our study provided the underlying molecular basis of altered brain activity, neurovascular coupling, and neuropsychiatric symptoms in COVID-19 survivors.

Impact: This study revealed that alterations in brain functional connectivity in pSS patients and exhibited temporal variability. It indicates that functional connectivity methods (GFC, DC, VMHC), particularly combining static and dynamic indicators, offer novel insights into early diagnosis and mechanism studies.

Impact: Time-varying thalamic connectivity abnormalities accompany fatigue development in multiple sclerosis. Distinct thalamo-cortical connectivity patterns, particularly involving insular, frontal, and cingulate regions, highlight progressive network dysregulation underlying fatigue emergence and chronicity, offering potential biomarkers for early fatigue identification and targeted intervention.