Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Altered Metabolism Across Healthy Aging and Neurological Disorders

Altered Metabolism Across Healthy Aging and Neurological Disorders

Oral

Neuro B

Tuesday, 12 May 2026

Ballroom East

08:20 - 10:10

Moderators: Malgorzata Marjanska & Guglielmo Genovese

Session Number: 404-02

CME/CE Credit Available

Similar Sessions

In this session, presentations on neurochemical alterations measured in the healthy aging brain, at rest or during activation, are followed by advanced MRS(I) applications in various neurological diseases, including multiple sclerosis, stroke, and gliomas. The methodologies employed range from proton single-voxel MRS and spectroscopic imaging to deuterium metabolic imaging.

Skill Level: Intermediate

08:20		404-02-001. Neurochemical Indicators of Cognitive Performance assessed by 7T MR Spectroscopy in the Aging Adult Brain Connectome Cohort Eva-Maria Ratai, Malgorzata Marjanska, Yue Hong, Yiwen Zhang, Melissa Terpstra, Guglielmo Genovese, Jeromy Thotland, Michael Wolf, Meher Juttukonda, Jan Kufer, Christa Michel, Courtney Accorsi, Adam Khay, Essa Yacoub, Petra Lenzini, Lauren Antonucci, Gayathri Vijayaraghavan, Steven Arnold, Robert Welsh, Jennifer Elam, Dara Ghahremani,, Carlos Cruchaga, Matthew Glasser, Michael Harms, Pauline Maki, Susan Bookheimer, Helen Lavretsky, Thomas Nichols, Beau Ances, David Salat Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America Impact: This study enhances our understanding of cognitive aging by revealing neurochemical patterns linked to preserved cognitive abilities in older adults, highlighting the role of MR spectroscopy in evaluating neuronal resilience in aging.
08:31		404-02-002. Aging alters the brain’s metabolic response to intense exercise: evidence from edited 1H-MR spectroscopy Lisa Krishnamurthy, Muhammad Saleh, Anastasia Bohsali, Elizabeth Krupinski, Joe Nocera, Keith McGregor, Tom Novak, Kevin Mammino, Venkatagiri Krishnamurthy Emory University School of Medicine, Atlanta, United States of America Impact: We highlight the utility of edited MRS to detect age-related differences in lactate transport and brain metabolism. Understanding these mechanisms may guide exercise interventions to improve and preserve brain health across the lifespan.
08:42		404-02-003. Functional 7T MRS Reveals Age-Related Metabolic Dynamics during Processing Speed Antonia Kaiser, Ying Xiao, Mark Widmaier, Lijing Xin CIBM Center for Biomedical Imaging, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland Impact: This study provides the first demonstration of dynamic glutamate, lactate, and GSH modulation during a cognitive task in humans and reveals their attenuation with aging. Functional 7T MRS enables direct assessment of neurometabolic efficiency underlying cognitive performance and decline.
08:53		404-02-004. In vivo biochemical subtyping of multiple sclerosis lesions using 7T 3D CRT free induction decay MRSI Rebeka Rumbak, Anita Kloss-Brandstätter, Fabian Niess, Bernhard Strasser, Lukas Hingerl, Stanislav Motyka, Thomas Berger, Guenther Grabner, Paulus Rommer, Wolfgang Bogner, Assunta Dal-Bianco, Eva Niess Medical University of Vienna, Vienna, Austria Impact: 7T CRT FID 3D-MRSI enables metabolic characterization of individual MS lesions, revealing reproducible biochemical phenotypes linked to paramagnetic rims, oxidative stress, tissue repair, and disability. This framework advances quantitative lesion-centric stratification for mechanistic studies and therapeutic monitoring in multiple sclerosis.
09:04		404-02-005. Altered GABA and Glx levels: MRI markers correlate with clinical disability in relapsing-remitting multiple sclerosis Ying Shi, Zhongkai Zhou, jianxiu lian, Pengfei Liu The First Affiliated Hospital of Harbin Medical University, Harbin, China Impact: GABA and Glx detected by MEGA-PRESS MRS were utilized for investigating correlations between metabolic abnormalities in GM atrophy regions and clinical disability.
09:15		404-02-006. Neurometabolic Network Remodeling Predicts Functional Recovery After Ischemic Stroke: A Longitudinal J-resolved 3D-MRSI Study Ziyu Meng, Shuoyun Feng, Chang Xu, Tianyao Wang, Yibo Zhao, Yudu Li, Wen Jin, Zhi-Pei Liang, Yao Li National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China Impact: Whole-brain metabolic connectomics provides a mechanistic, patient-level biomarker of stroke recovery. By linking neuronal and neurotransmitter network reorganization to lesional metabolism and clinical outcome, it provided novel biomarkers for personalized prognosis, treatment selection, and implementation of network-targeted, metabolically-guided rehabilitation strategies.
09:26		404-02-007. Relationships between key brain tumor metabolites in grade 2-3 astrocytoma and oligodendroglioma Dunja Simicic, Seyma Alcicek, Lindsay Blair, Max Saint-Germain, Helge Zoellner, Zsombor Ritter, Jaishri Blakeley, Christopher Davies-Jenkins, Matthias Holdhoff, John Laterra, Chetan Bettegowda, Karisa Schreck, Doris Lin, Peter Barker, David Kamson, Georg Oeltzschner Johns Hopkins University School of Medicine, Baltimore, United States of America Impact: 2HG-total choline-glutamine associations appear in astrocytoma (but not oligodendroglioma) and grade-2 (but not grade-3) glioma. This suggests distinct metabolic mechanisms in different molecular tumor types, as well as (together with glutamine differences between grades 2-3) metabolic shifts during malignant transformation.
09:37		404-02-008. Glycine as an Imaging Biomarker of Rapid Glioma Proliferation and Predictor of Recurrence: A Study With Glycine-Targeted MRS Xiaozhu Hao, Kai Huang, Yefeng Yao, Zhenwei Yao Huashan Hospital, Fudan University, China Impact: Glycine-targeted MRS provides an in vivo biomarker for assessing glioma invasiveness, that Gly+ indicates rapid proliferation and higher recurrence risk, aiding in optimizing treatment strategies.
09:48		404-02-009. Deuterium metabolic imaging for assessing response to chemoradiotherapy in high grade glioma: a multisite study Alixander Khan, Otso Arponen, Giorgia Carnicelli, Ines Horvat-Menih, Nikolaj Bøgh, Maria Zamora Morales, Esben Hansen, Ashley Grimmer, Elizabeth Latimer, Nichlas Vous Christensen, Michael Væggemose, Uffe Kjærgaard, Sebastian Bauer, Jonathan Birchall, Joshua Kaggie, Rolf Schulte, Anders Vittrup, Ane Iversen, Matthew Locke, Marta Wylot, Fiona Harris, Tomasz Matys, Raj Jena, Slávka Lukacova, Mary McLean, Christoffer Laustsen, Ferdia Gallagher Aarhus University, Aarhus, Denmark Impact: Our findings suggest DMI can non-invasively measure treatment response in high grade glioma following chemoradiotherapy. The relationship between metabolic measurements and prognosis for patients supports further investigation into the application of DMI for oncological treatment response.
09:59		404-02-010. Characterizing mutant IDH glioma and their treatment responses in vivo using proton MRS and deuterated α-ketoglutarate Donghyun Hong, Peder Larson, Sabrina Ronen University Of California, San Francisco (UCSF), United States of America Impact: This is the first study demonstrating that proton spectroscopy after deuterated α-ketoglutarate infusion enables noninvasive monitoring of normal and glioma metabolism and treatment response, identifying a clinically translatable approach for characterizing and tracking mutant IDH tumors in patients.