Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Novel Contrast Mechanisms I

Digital Poster

Contrast Mechanisms

Wednesday, 13 May 2026

Digital Posters Row H

16:00 - 16:55

Session Number: 567-05

No CME/CE Credit

Similar Sessions

This session highlights recent advances in novel MRI contrast mechanisms including physical principles, technical development, and emerging applications.

		567-05-001. Dark-Blood Late Gadolinium Enhancement Imaging with Unbalanced Steady-State Free Precession Bora Bozdag, Tess Wallace, Manuel Morales, Patrick Pierce, Scott Johnson, Warren Manning, Robert Edelman, Reza Nezafat University of Oxford, Oxford, United Kingdom Impact: Current dark-blood LGE techniques require a dedicated preparation module or timing constraints to achieve blood suppression. The proposed IR-uSSFP-Echo sequence intrinsically nulls the blood signal, allowing further optimization of contrast for scar visualization.
		567-05-002. Whiteout sign (WOS) and narrow middle domain (mD), repeatability and consistency on all vendor systems Paul Condron, Daniel Cornfeld, Mark Bydder, Tracy Melzer, Gil Newburn, Eryn Kwon, Taylor Emsden, Miriam Scadeng, Samantha Holdsworth, Graeme Bydder Mātai Medical Research Institute, Gisborne, New Zealand Impact: We describe how to exploit the middle Domain (mD) to depict the whiteout sign on different MR systems. Different methods of inversion pulse application change the observed T₁s of tissues and need to be compensated for to produce consistent results.
		567-05-003. Preclinical Sequence Optimization for 129Xe HyperCEST MRI Applications Using a Phantom Simulating In Vivo Relaxation Times Hannah Gerbeth, Leonard Bender, Luca Kempny, Alexandra Lipka, Viktoria Bayer, Samuel Lehr, Leif Schröder German Cancer Research Center (DKFZ), Heidelberg, Germany Impact: The growing demand for non-gadolinium MRI contrast agents highlights the relevance of advancing xenon biosensor technologies. This in vitro phantom solution facilitates translation of ¹²⁹Xe HyperCEST toward clinical use by enabling efficient optimization of imaging protocols under controlled, reproducible conditions.
		567-05-004. Radiofrequency switchable contrast agents for unambiguous image labelling Gary Zabow, Stephen Dodd, Alan Koretsky National Institute of Standards and Technology, Boulder, United States of America Impact: Contrast agents are often confused with background image features, signal voids, and/or noise. The new imaging mechanism described here enables agents that can be reversibly turned on and off, thus removing conventional image contrast ambiguities that confound MRI studies.
		567-05-005. Reduction of water exchange in normal aging and Alzheimer’s disease measured with T2-selective saturation imaging Manuel Taso, Christopher Brown, Ruby Bouhassira, Rupal Bhavsar, Geoffrey Aguirre, David Wolk, John Detre University of Pennsylvania, Philadelphia, United States of America Impact: This work leverages novel methods studying water exchange, demonstrating signal changes associated with aging and Alzheimer's disease, potentially suggesting brain waste clearance alterations with distinctive spatial patterns between aging and AD.
		567-05-006. Equation-based k-space boosting increases arterial-phase CNR in gadoxetate-enhanced liver MRI: a preclinical evaluation. Felix Kreis, Gregor Jost, Gunnar Schuetz, Sebastian Gerz, Andreas Bolz, Hubertus Pietsch Bayer AG, Berlin, Germany Impact: An equation-based k-space boosting algorithm raised arterial-phase CNR of gadoxetate-enhanced liver MRI to levels comparable with an extracellular agent in a porcine model, potentially improving lesion conspicuity, diagnostic confidence, and enabling single-agent protocols without repeat examinations.
		567-05-007. Isolation and labelling for MRI-based tracking of orange-derived extracellular vesicles as drug delivery nanosystems Chiara Romiti, Diego Alberti, Silvio Aime, Giovanni Camussi, Margherita Pomatto, Carla Carrera, Lucia Massari, Massimo Cedrino, Simonetta Geninatti Crich University of Turin, Turin, Italy Impact: This study establishes a labelling method for orange-derived extracellular vesicles (EVs), enabling non-invasive MRI tracking of a novel class of nanocarriers. It supports future in vivo research for EVs from edible sources, owning a huge potential for oral delivery applications.
		567-05-008. Signal enhancement of gadoquatrane for routine clinical pulse sequences: a phantom study in human plasma Gregor Jost, Hubertus Pietsch Bayer AG, Berlin, Germany Impact: Gadoquatrane is a novel tetrameric, macrocyclic gadolinium-based contrast agent (GBCA) with high r1-relaxivity currently in clinical development. The characterization of the signal enhancement properties with standard clinical pulse sequences is important for a potential clinical use at lower gadolinium dose.
		567-05-009. USPIO-enhanced MRI in the brain: the in vivo relaxivities r1 and r2* of Ferumoxtran-10 at 3T Rik van den Elshout, José Marques, Jack van Asten, Patrik Zamecnik, Dylan Henssen, Tom Scheenen Radboud University Medical Center, Nijmegen, Netherlands Impact: We established reference values for the blood in vivo relaxivities of an USPIO at 3T. Future work can use these reference values to quantify blood volume in T1 imaging at high spatial resolution
		567-05-010. Multinuclear Low-field Pre-clinical MRI Scanner Gonzalo Rodriguez, Sergey Korchak, Charlotte von Petersdorff-Campen, Oscar Sucre, Jan Felger, Ruhuai Mei, Stefan Glöggler Max Planck for Multidisciplinary Sciences, Göttingen, Germany Impact: We introduced a multinuclear low-field scanner optimized for pre-clinical investigations at 66 mT. This platform will enable the development of hyperpolarized contrast agents specifically targeted for the low field regime.
		567-05-011. A novel temperature-regulated dynamic phantom for MRI calibration against a biochemical reaction reference standard Max Bullock, Fraser Hill-Casey, rafat chowdhury, lorna smith, Christoph Müller, Vencel Somai, Fiona Gong, Morayo Adebakin, Pascal P.R. Ruetten, Ilai Schwartz, Shonit Punwani, Xavier Golay, Aaron Oliver-Taylor Impact: We demonstrate a thermally stabilised (36.3 °C ± 0.2 °C) dynamic phantom that acts as a reproducible calibration standard for physiologically relevant hyperpolarised ¹³C MRI studies, enabling site-to-site harmonisation of metabolic studies.
		567-05-012. Tracking fixation effects in Gray Matter: comparative qMRI analysis of ex-vivo temporal lobes Laura Bogs, Nina Luethi, Francisco Fritz, Jan Malte Oeschger, Sophie Otte, Noemie Sura, Thomas Sauvigny, Laurin Mordhorst, Thorsten Feiweier, Mattias Heinrich, Siawoosh Mohammadi University of Lübeck, Lübeck, Germany Impact: This work shows that fixation models can describe changes of qMRI parameters occurring at different time-intervals during fixation of whole brain and temporal lobe specimens. Therefore, they might help translate MRI-histology relationships obtained from fixed ex-vivo samples to in-vivo settings.
		567-05-013. A Comparative Study of Brain/Liver MR Image Quality between PETMR and standalone MR scanners in Clinical Practice Dandan Hu, Jun Chen, Pin Lv, Hailong Zhang, Jiaming Lu, Bing Zhang, Xin Zhang, Ming Li Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China Impact: This study confirms that uPMR 790’s PET detector does not impair MR quality, supporting its clinical use and providing a basis for multi-center MR studies.
		567-05-014. Impact of Magnetization Transfer on Diffusion Microstructure Estimates in Rodent Gray Matter Andreea Hertanu, Lucas Soustelle, Guillaume Duhamel, Olivier Girard Aix Marseille Univ, Marseille, France Impact: In this work we show that in gray matter, the extra-cellular space exhibits greater MT-sensitivity than the intra-neurite compartment, opposite to the pattern previously reported in white matter, highlighting new opportunities to exploit this property.
		567-05-015. MRI in clinical practice: rapid and contrast-free MRI exams of neurovascular pathologies using MR-STAT Martin Schilder, Edwin Versteeg, Stefano Mandija, Oscar van der Heide, Fei Xu, Jan Willem Dankbaar, Mervyn D.I. Vergouwen, Ynte Ruigrok, Tristan P.C. van Doormaal, Irene van der Schaaf, Cornelis van den Berg, Alessandro Sbrizzi UMC Utrecht, Utrecht, Netherlands Impact: Expensive diagnostic MRI protocols and frequent follow-ups for neurovascular populations burden individual patients, healthcare systems and society. MR-STAT offers a rapid, contrast-free alternative, aiming to streamline neurovascular diagnostics and reduce scan time while maintaining diagnostic accuracy.
		567-05-016. Cross-scanner and cross-field-strengths validation of liver MRI biomarkers in healthy volunteer Xiandan Shang, Dandan Kou, Xie Yingxin, Jun Chen, Xiance Zhao, Bo yu Jiang, Fei Xiang, Ming Li, Xin Zhang, Hongyan Zhu, Zengping Lin, Yang Yang Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China Impact: This study provides important evidence for repeatability and agreement of liver 2D MRE, PDFF and R2* across different scanners among 3T and 5T, which is crucial for establishing standardized calibration in multi-center quantitative MRI studies.