Advances in ASL
Digital Poster
Contrast Mechanisms
Thursday, 14 May 2026
This session presents the latest advances in arterial spin labeling
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661-01-001.
Evaluating Cerebral Blood Flow in Chronic Fatigue Syndrome Using Velocity-selective Arterial Spin Labeling MRI
Impact: This study identifies neurovascular
dysfunction as a potential contributor to fatigue and cognitive symptoms in
ME/CFS and Long COVID. Non-contrast velocity-selective ASL MRI detection of
regional cerebral hypoperfusion offers a promising biomarker for understanding,
monitoring, and treating neuroimmune disorders.
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661-01-002.
High Resolution Multi-delay ASL using a Hybrid k-d Sampling Strategy at 7T
Impact: This work enables high-resolution multi-delay ASL
at 7T by adaptively balancing spatial resolution and SNR, supporting improved simultaneous
assessment of cerebral blood flow and arterial transit time in the same scan
time as single-delay ASL.
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661-01-003.
Simplified Method for Assessing Blood-CSF Barrier Function in Humans using multi-TE / PLD pCASL
Impact: Single-kernel delivery model using the optimal
echo-time from multi-TE/PLD pCASL data well localized blood-to-CSF regions near
the choroid-plexus and ventricles, Consistent-ATT-CSF(2.8–3.0 s) fast-CSF-uptake(≤60s, p<0.005) comparable to two-compartmental models.
This can significantly reduce fitting-complexity/scan-time, facilitating
broader dissemination of neurofluid-dynamic assessments.
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661-01-004.
Blood–Brain-Barrier Water Permeability Imaging Using An Accelerated Background Suppressed Stack-of-Spirals mTE-pCASL MRI
Impact: mTE-pCASL with
accelerated stack-of-spirals readout offers a clinically feasible tool to
reliably measure BBB water permeability.
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661-01-005.
A 3D-printed phantom for validating pre-clinical ASL cerebral perfusion measurements.
Impact: A 3D-printed perfusion phantom has been designed to optimise and validate ASL methods. It will be used to improve
the quantitative accuracy and reproducibility of ASL perfusion measurements,
providing a robust framework for refining method performance prior in vivo
application.
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661-01-006.
The value of ASL and synthetic MRI for characterizing gray matter heterotopia in patients with epilepsy
Impact: For the first time, our study showed showed ASL and syMRI can quantitatively characterize the differences between GMH and NGM, thereby establishing a foundation for future research in this field.
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661-01-007.
The value of m-ASL in evaluating territorial perfusion injury in patients with posterior circulation ischemic stroke
Impact: This study enables accurate assessment of posterior circulation perfusion in PCIS patients and detailed mapping of perfusion impairment patterns across different vascular territories and infarct lesions, providing comprehensive imaging support for understanding its hemodynamic injury mechanisms.
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661-01-008.
B1+ and slice profile effects on dynamic ASL signal evolution with optimized flip angle trains
Impact: This closed-form variable flip angle formula stabilizes dynamic ASL signal intensity across the readout, enabling higher-quality angiograms for vascular diseases. However, this study shows that B1+ inhomogeneities and slice profiles must be carefully considered.
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661-01-009.
A latent space optimization framework for arterial spin labeling-based cerebral blood flow maps reconstruction
Impact: ASL
suffers from poor SNR and longer scan time, limiting its clinical utility. A
lightweight deep learning framework, PSO-optimized VQVAE, enables
reconstruction of accurate CBF maps from fewer acquisitions, improving the
adaptability of contrast-free ASL perfusion imaging in clinical practice.
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661-01-010.
Voxelwise T2-Corrected Multi-TE ASL for Perfusion and Permeability Difference in Gliomas and Meningiomas
Impact: Voxelwise T2-corrected multi-TE ASL approach resulted in a noninvasive assessment of cerebral blood flow (CBF) and water exchange (Tex) measures in meningiomas and gliomas. Meningiomas exhibited higher corrected-CBF and Tex than gliomas.
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661-01-011.
Achieving Vendor-Agnostic Perfusion Imaging with PCASL using the Pulseq Framework
Impact: This study
presents a Pulseq-based PCASL sequence that achieves vendor-agnostic perfusion
imaging while holding promise to reduce inter-scanner variability in CBF
quantification across different vendor scanners, enabling standardized,
reproducible multi-center ASL studies and open-source sequence deployment in
clinical research.
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661-01-012.
Renal Perfusion at midfield (0.6T) using Arterial Spin Labeling; feasibility and comparison to 3T
Impact: Renal
perfusion measurements at 0.6T using FAIR-ASL are comparable to those obtained
at 3T. This study demonstrates the potential of midfield MRI combined with ASL
to enable accessible, non-invasive evaluation of renal hemodynamics relevant to
physiologic and/or therapeutic monitoring
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661-01-013.
Contrast-free Imaging of Blood Brain Barrier Water Exchange in Depression
Impact: This project
uses in vivo neuroimaging to characterize BBB function in individuals with MDD. Non-contrast
MRI of BBB water exchange may serve as an imaging biomarker for neuroimmune
involvement in depression.
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661-01-014.
Temporal evolution acquisition (TEA) based ASL for arterial blood T2 mapping at 5 T
Impact: The proposed variable RFA TEA-ASL technique combined with EPG-based dictionary fitting enables more accurate and noise-robust arterial blood $T_2$ quantification at 5T, advancing the reliability of multi-echo ASL for assessing blood-brain barrier water exchange or oxygen extraction fraction.
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661-01-015.
Laminar and Subfield-Specific Microvascular Pulsatility of the Human Hippocampus in 7T MRI
Impact: We introduce a 7 T MRI–based hippocampal microvascular volumetric pulsatility index (mvPI), revealing region- and layer-specific vascular dynamics coupled with CSF pulsation, offering new insight into hippocampal vascular regulation and neurovascular–CSF interactions.
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