Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Neuroimaging Biomarkers Across the Spectrum of Brain Disorders

Neuroimaging Biomarkers Across the Spectrum of Brain Disorders

Digital Poster

Neuro B

Thursday, 14 May 2026

Digital Posters Row J

09:25 - 10:20

Session Number: 669-02

No CME/CE Credit

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This poster session brings together a broad and diverse selection of studies illustrating the wide scope of contemporary neuroimaging research. The presented works span multiple neurological and neuropsychiatric conditions, including neurodegenerative, inflammatory, vascular, metabolic, developmental, and tumoral disorders, as well as methodological and technical developments. Using advanced MRI approaches—ranging from quantitative and multimodal imaging to ultra-high-field techniques and biomarker-oriented analyses—the session highlights how neuroimaging contributes to understanding brain structure, function, metabolism, and disease mechanisms across heterogeneous clinical and research contexts.

Skill Level: Intermediate

		669-02-001. Cerebral blood flow alteration and its association with host gene in long-COVID patients: A transcriptomic-neuroimaging study Yao Wang, Jiankun Dai, Fuqing Zhou Shandong Cancer Hospital, Jinan, Shandong, China Impact: Our findings shed light on the intricate interplay between altered CBF, gene expression, and clinical symptoms in long COVID, potentially guiding future research on CNS outcomes, genetic associations, and therapeutic targets.
		669-02-002. Cerebral Metabolic Stress Links Insulin Resistance, Rather Than Hyperglycemia, to Functional Decline Sri Sai Akkineni, Dhruv Bhagat, Lea Bergeot, Fahad Salman, Ferdinand Schweser, Junghun Cho, Rafeeque Bhadelia, Katherine Tucker, Salil Soman Medical College of Georgia, Augusta, United States of America Impact: This study provides the first neuroimaging evidence linking insulin resistance to cerebral metabolic stress, explaining HOMA-IR's superiority over HbA1c. This establishes OEF as a new, quantifiable target for therapies aimed at preserving brain function in older adults.
		669-02-003. Integrating MR imaging, clinical, and lifestyle data to predict organ-specific aging Veronika Ecker, Tim Förster, Sergios Gatidis, Thomas Küstner, Bin Yang University Hospital of Tuebingen, Tuebingen, Germany Impact: Our multimodal framework allows early detection of accelerated brain and heart aging, providing a foundation for risk stratification and personalized intervention in populations at risk.
		669-02-004. Quantitative oxygen extraction fraction (OEF) mapping in Huntington’s disease Arpita Misra, Ana-Maria Oros-Peusquens, Kathrin Reetz, Imis Dogan, Jörg Schulz, Yi Wang, N. Jon Shah, Junghun Cho George Washington University, Washington, United States of America Impact: This study demonstrates QQ’s feasibility for detecting oxygen-metabolism abnormalities in Huntington’s disease. Our findings suggest that QQ can be effectively applied to investigate the disease’s pathophysiology and contribute to the development of improved therapeutic strategies.
		669-02-005. Dynamic Volumetric Changes of Limbic System in AD Spectrum: A Marker for Progression Monitoring Yuanyuan Zhao, Luoyu Wang, Yihan Suo, Hanjun Hu, Zhongxiang Ding Zhejiang Chinese Medical University, Hangzhou, China Impact: We included the entire limbic system, which is currently missing in the research. The results helped us better understand the changing trends of limbic structure brain regions in the progression of AD.
		669-02-006. Standardising Neuroimaging for Dementia Research in Resource-Limited Settings: Pilot Central Review from the READD-ADSP Study Akanimoh Ekpe, Adesola Adepoju, Benjamin Aribisala, Kafilat Afolabi, Victor Ogaji, Adesola Ogunniyi, Olusegun Baiyewu, Mayowa Ogunronbi, Olufisayo Elugbadebo, Reginald Obiako, Kolawole Wahab, Adefolake Ogundele, Paul Nwani, Godwin Osaigbovo, Judith Boshe, Damas Mlaki, Albertino Damasceno, Yared Zewde, Alfred Njamnshi, Njideka Okubadejo, Margaret Pericak-Vance, Rufus Akinyemi, Godwin Ogbole University College Hospital, Ibadan, Nigeria Impact: Establishing a feasible standardized neuroimaging review infrastructure across African centers which would significantly improve data quality, consistency and readiness for large-scale dementia research. Scaling this framework is expected to strengthen continental neuroimaging collaboration and contribute to global Alzheimer’s disease datasets.
		669-02-007. Iron-Related Susceptibility Changes in the Hypothalamus of Narcolepsy Type 1 Patients Greta Venturi, Lorenzo Motta, Francesco Biscarini, Fabio Pizza, Francesca Punzetti, Martina Gnazzo, Raffaele Lodi, Giuseppe Plazzi, Caterina Tonon IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy Impact: By identifying iron-related and glial changes in the hypothalamus of narcolepsy type 1, this work shows that quantitative susceptibility imaging enables more sensitive, in vivo assessment of brain alterations linked to hypocretin neuron loss, enhancing clinical interpretation beyond conventional imaging.
		669-02-008. Quantitative MRI Biomarkers of Myelin: Cross-Validation and Diagnostic Performance in Multiple Sclerosis James Lo, Sarah Tang, Nathan Chan, Dylan Tran, Jiyo Athertya, Mohamad Amin Cheraghi, Soo Hyun Shin, Jiang Du, Graeme Bydder, Yajun Ma University of California, Berkeley, United States of America Impact: These findings show that quantitative MRI biomarkers MPF, MWF, MMF, and MTR provide complementary yet distinct measures of myelin integrity in MS, with MPF and MTRc offering the highest diagnostic accuracy, supporting their potential as clinical markers for demyelination assessment.
		669-02-009. MRI histogram and VASARI features for predicting CD163+ tumor-associated macrophages in glioblastomas. Jia Kang, qing zhou Lanzhou University Second Hospital, Lanzhou, China Impact: Early noninvasive MRI-based prediction of CD163+ macrophage infiltration in GBM enables improved prognostic stratification, informs personalized treatment planning, and may guide future research into immunotherapeutic targets to enhance patient outcomes.
		669-02-010. 3D T2-Weighted FLAIR Imaging at 7T with Double Inversion Recovery and T2-Prepared Inversion Recovery SPACE Zeyu Liu, Shengzhen Tao, Erik Middlebrooks, Chen Lin, Xiangzhi Zhou Peking Union Medical College Hospital, Beijing, China Impact: Our optimization of T2Prep-IR and DIR modules for 3D T2-weighted FLAIR imaging at 7T produced comparable overall image quality. DIR was found to be preferable for T2 weighted WM-GM contrast, whereas T2Prep-IR provided lower noise levels and reduced SAR.
		669-02-011. Changes in the volume and functional connectivity of the subcortical nuclei in infants with biliary atresia: A multimodal MRI Qi Zhang, Chen Zhang, Yue Cheng First Hospital of Shanxi Medical University, Taiyuan, China Impact: This study provides new insights into the neuropathological mechanisms of infants with BA and lays a scientific foundation for early intervention and neuroprotective treatment.
		669-02-012. Fixel-Based Analysis Reveals Key Pathway of White Matter Injury in Pediatric Spastic Cerebral Palsy Yitong Bian, Xiao Yan, Zhen Jia, Zhe Liu, Xianjun Li, jian Yang The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China Impact: FBA reveals that reduced fiber complexity is a key feature of corticospinal tract damage in SCP. CX serves as a sensitive biomarker for motor impairment, enabling precise assessment of white matter pathology beyond conventional DTI capabilities.
		669-02-013. Associations Between Brain Metabolite Alterations and Clinical Improvements in Children With ASD Following UCB-MNCs Therapy Zhijuan Li, Xiaotong Li, Ning Zheng, Jing Peng, Lixia Zhou The Second Hospital of Hebei Medical University, Shijiazhuang, China Impact: UCB-MNC treatment alleviate core symptoms in children with Autism Spectrum Disorder (ASD). MRS provides imaging evidence for evaluating the efficacy of UCB-MNCs in treating ASD and offers important references for further elucidating the neural mechanisms underlying clinical improvement.
		669-02-014. Optimizing parallel transmission with reduced field-of-view for 7T spinal cord MRI Charles Betemps, Vincent Gras, Joseph Brégeat, Virginie Callot, Aurelien Destruel Aix Marseille Univ, Marseille, France Impact: Reduced-FOV pTx excitation in the spinal cord at 7T can provide high-spatial resolution while maintaining scan times compatible with clinical and hardware constraints. Although additional work is required for in-vivo applications, current work opens great perspectives for improved SC-disease characterization.
		669-02-015. Magnetic Resonance Microscopy of the Postmortem Fixed Human Spinal Cord Govind Nair, Roy Sun, Brandon Bujak, Kevin Hu, Cammille Rood, Katherine Cameron, Silvina Horovitz , Stephen Dodd National institute of of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), BETHESDA, United States of America Impact: Postmortem MRI of the human spinal cord at 75-micron isotropic resolution from one donor presented here revealed several demyelinating lesions along its length. This enabled not only the direct comparison with in-vivo scans but also targeted histopathology.