Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

New Frontiers in CEST MRI

Oral

Contrast Mechanisms

Wednesday, 13 May 2026

Meeting Room 1.40

13:40 - 15:30

Moderators: Xiang Xu & Ouri Cohen

Session Number: 507-03

No CME/CE Credit

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This oral session features abstracts on novel pulse sequences, reconstruction methods, and emerging applications of CEST imaging.

Skill Level: Advanced

13:40		507-03-001. Introduction Ouri Cohen Memorial Sloan Kettering Cancer Center, New York, United States of America
13:51		507-03-002. Optimizing 3T GlucoCEST MRI for Bladder Cancer: Effects of Glucose Concentration, pH, and Sequence Parameters Jing-Lu Li, Wen-Li Yang, Yu-Tao Jiang, Yun Xu, Yong-Sheng Xiang, Pu-Yeh Wu, Pei-Jun Wang, Fang Wang, Ai-Jun Shen Tongji Hospital, School of Medicine, Tongji University, Shanghai, China Impact: The optimized 3T glucoCEST MRI protocol demonstrates reliable, contrast-free detection of bladder cancer, enhancing metabolic imaging sensitivity. It supports glucoCEST as a promising, non-invasive imaging biomarker reflecting tumor glucose metabolism and microenvironment acidity, potentially improving diagnosis and treatment monitoring.
14:02		507-03-003. Endogenous CEST Signals Enable Simultaneous In Vivo pH and Temperature Mapping: A Proof-of-Principle Study Philip Boyd, Jana Lechner, Jannis Wirtz, Vanessa Franke, Mark Ladd, Peter Bachert, Andreas Korzowski German Cancer Research Center (DKFZ), Heidelberg, Germany Impact: We present the first method for non-invasive, high-resolution in vivo pH and temperature mapping using endogenous CEST imaging. By simultaneously quantifying these fundamental physiological parameters, our approach provides powerful biomarkers with broad potential for disease detection, characterization and treatment monitoring.
14:13		507-03-004. Application of quantitative guanidinium CEST-based pH mapping in healthy and pathological leg muscles at 3T Valentin Henriet, Pierre-Yves Baudin, Benjamin Marty, Marc Lapert, Harmen Reyngoudt Institute of Myology, Paris, France Impact: High-resolution pH mapping with CEST-MRI is sensitive to subtle pathophysiological changes, enabling assessment of cellular homeostasis and early detection of cellular disturbances, positioning CEST-based pH as a promising predictive biomarker for neuromuscular disorders.
14:24		507-03-005. Spectral-Spatial Deep Learning for Quantitative gagCEST Mapping of Lumbar Intervertebral Discs Mohamed Ali Goundi, Karl Ludger Radke, Matthias Georg Deitermann, Timm Joachim Filler, Hans-Joerg Wittsack, Daniel Benjamin Abrar, Gerald Antoch, Anja Müller-Lutz Medical Faculty, Heinrich Heine University Düsseldorf (DE), Düsseldorf, Germany Impact: A spectral–spatial fusion model trained on anatomically realistic gagCEST simulations enables quantitative mapping of GAG concentration in lumbar intervertebral discs (IVDs), providing a reproducible framework that could support the future development of compositional MRI biomarkers for early disc degeneration.
14:35		507-03-006. 3D EPTI-CEST: Snapshot and distortion-free whole-brain 3D CEST MRI Jian Wu, Paul Weiser, Ovidiu Andronesi, Zijing Dong, Fuyixue Wang Massachusetts General Hospital and Harvard Medical School, Boston, United States of America Impact: The proposed 3D-EPTI-CEST enables snapshot, distortion-free whole-brain CEST imaging at 2-mm-iso at both 3T and 7T, providing reliable CEST contrast strongly correlated with reference metabolite concentration (as demonstrated in phantom) and high image quality (as in ex-vivo and in-vivo experiments).
14:46		507-03-007. Spatial-Frequency Feature Learning for Fast Amide Contrast Mapping from Sparse CEST Offsets PEI CAI, Ziyan Wang, Jiawen Wang, Huabin Zhang, Shihao Zeng, Ka Fung Henry Mak, Lequan Yu, Jianpan Huang The University of Hong Kong, Hong Kong, China Impact: This study demonstrates that incorporating spatial–frequency feature learning enables accurate amide contrast reconstruction from sparse CEST data, significantly reducing acquisition and fitting time while maintaining quantitative integrity, paving the way for rapid multi-contrast molecular MRI.
14:57		507-03-008. Quantitative 7 T CEST Imaging of Metabolic Integrity in Multiple Sclerosis: Aging and Lesion effects Sebastián Navarrete, Milena Capiglioni, Stefanie Marti, Lukas Pirpamer, Richard McKinley, Robert Hoepner, León Betancourt, Piotr Radojewski Universidad de Concepción, Concepción, Chile Impact: This study shows that 7T CEST captures age-dependent and lesion-volume contrast differences between MS and healthy tissues, suggesting a possible link between metabolic integrity and MS pathology.
15:08		507-03-009. Towards Reliable CEST Imaging of the Breast: Evaluation of Fat Correction Strategies at 3T Neele Kempa, Petr Menshchikov, Mark Ladd, Peter Bachert, Andreas Korzowski, Philip Boyd German Cancer Research Center (DKFZ), Heidelberg, Germany Impact: We systematically evaluated fat correction strategies for CEST breast imaging in healthy volunteers. The identified optimal approach brings forward clinical applications in breast cancer imaging and screening, and may further benefit CEST studies in other fat-containing body regions.
15:19		507-03-010. In Vivo Human Brain CEST MRI at 11.7T: First Results Camélia Ressam, Joseph Brégeat, Alfredo Lopez Kolkovsky, Alexis Amadon, Alexandre Vignaud, Aurélien Massire, Son Chu, Shajan Gunamony, Nicolas Boulant, Vincent Gras, Franck Mauconduit, Luisa Ciobanu CEA NeuroSpin, Paris-Saclay University, CNRS, Gif-Sur-Yvette, France Impact: This study demonstrates effective mitigation of B₁⁺ inhomogeneity, establishing the feasibility of CEST imaging at 11.7T and paving the way for future investigations of gray-white matter contrast and metabolite-weighted signals in the human brain at ultra-high-field.