Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Diffusion Tractography

Oral

Diffusion

Tuesday, 12 May 2026

Auditorium 1

08:20 - 10:10

Moderators: Maryam Seif & Julien Cohen-Adad

Session Number: 403-01

CME/CE Credit Available

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This oral session showcases advances in diffusion MRI tractography spanning methodological innovation, neuroanatomical investigation, and clinical application. Presentations will highlight novel algorithmic approaches for improved fiber reconstruction, new insights into white matter organization and connectivity, and emerging uses of tractography in presurgical planning, neurological disease characterization, and treatment monitoring.

Skill Level: Intermediate

08:20		403-01-001. From Fixels to Tracts: Overcoming Limitations of Fixel-Based Inference with STRIFE Simone Zanoni, Robert Smith, Jinglei Lv, Fernando Calamante The University of Sydney, Sydney, Australia Impact: We introduce a novel modification for Fixel-Based Analysis (FBA) that enables Statistical TRact-wise Inference from Fixel-level Effects (STRIFE). STRIFE directly yields bundle-defined effects without relying on subjective post-hoc attribution of fixel results to specific tracts, thereby improving interpretability.
08:31		403-01-002. Motion-Robust Tractography through Single-Shot Triple-Echo SMS-EPI with Dynamic Field and Motion Correction Liam Timms, Miriam Hewlett, Cemre Ariyurek, Hongli Fan, Stephen Cauley, Sila Kurugol, Onur Afacan Boston Children's Hospital, Boston, United States of America Impact: Our single-shot triple-echo SMS-EPI sequence enables dynamic, slice-wise correction of motion and susceptibility artifacts. This provides more robust, accurate brain tractography in the presence of severe motion, facilitating reliable diffusion imaging for pediatric and uncooperative patient populations.
08:42		403-01-003. Directional derivatives for neuromodulation targeting: revealing topographic features in connectivity-sensitive regions Simona Leserri, Kalle Saarinen, Dogu Baran Aydogan University of Eastern Finland, Kuopio, Finland Impact: Directional derivative images provide a new contrast for studying subject-specific white-matter connectivity organization. The information they reveal enables research on topographic brain variability and interpretation of white-matter architecture. These images may serve as valuable planning tools for neuromodulation interventions.
08:53		403-01-004. Combined MR – histology – micron-resolution fiber mapping towards multimodal microscopic validation of MRI Andy Liu, Yixin Wang, Matthew Choi, Derek Days, Michael Zeineh, Marios Georgiadis Stanford Medicine, Stanford, United States of America Impact: Showing that micron-resolution fiber orientations from ComSLI can be precisely mapped to MRI volume fata from human specimens, we aim to enable detailed validation and optimization of MR tractography, and combined MR-histology-microtractography investigations.
09:04		403-01-005. Across-scales connectivity mapping of the marmoset brain Runjia Lin, Tianjia Zhu, Minhui Ouyang, Hao Huang University of Pennsylvania, Philadelphia, United States of America Impact: Ground-truth viral tracing, ex vivo ultra-high resolution dMRI, and in vivo regular dMRI offer invaluable insight into the brain connectivity at the level of µm, 100 µm and 1000 µm. We developed a method enabling direct integration of across-scales connectivity.
09:15		403-01-006. Diffusion tractography maps pathways that explain direct and indirect electrophysiological connectivity S Shailja, Dian Lyu, Gustavo Chau Loo Kung, Leili Mortazavi, Erpeng Dai, Karl Deisseroth, Vivek Buch, Josef Parvizi, Jennifer McNab Stanford University, Stanford, United States of America Impact: We show that tractography can reliably and non-invasively map electrophysiological signaling. This has broader implications for both scientific research and clinical practice including guidance for placement of electrodes in functional neurosurgeries.
09:26		403-01-007. White Matter Neural Circuit in the Human Brain: A Cluster-Level Identification via Ensemble Tractography Zhonghua Wan, Chengzhe Zhang, Yu Xie, Yifei He, Jiaolong Qin, Huifeng Zhang, Xiaoming Liu, Ye Wu School of Computer Science and Technology, Nanjing University of Science and Technology, Nanjing, China Impact: This research presents a detailed, anatomically consistent neural circuit atlas constructed via fiber clustering. This provides future researchers with a high-fidelity data resource for studying brain structural connectivity, thereby deepening our understanding of brain organization.
09:37		403-01-008. High‑Resolution Diffusion Tractography Shows Altered Superficial White Matter in Multiple Sclerosis Across the Lifespan Alejandro Acosta, Javier Urbina-Alarcón, Adithi Madireddy, Zhongyi Sun, Carly Weber, Penelope Smyth, Gregg Blevins, Colin Wilbur, Nabeela Nathoo, Derek Emery, Christian Beaulieu University of Alberta, Edmonton, Canada Impact: Diffusion tractography identified microstructural abnormalities of the under-studied normal-appearing superficial white matter in multiple sclerosis (MS) across the lifespan. This highlights the broad impact of MS on the brain and may provide insight on regional demyelination and disease progression.
09:48		403-01-009. Toward patient-specific prediction of recurrence directions in glioblastoma: a tractography-based Index of Tumor Invasiveness Elena Cantoni, Giovanni Sighinolfi, Gianluca Carlini, Gianfranco Vornetti, Paola Berardi, Caterina Tonon, Raffaele Lodi, David Neil Manners IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy Impact: The Index of Tumor Invasiveness (ITI) provides an individualized, directionally anisotropic estimation of glioblastoma infiltration pathways, enabling enhanced target delineation for precision radiotherapy with reduced irradiation of healthy tissue, with potential applications extending to neurosurgical planning and refined oncologic characterization.
09:59		403-01-010. Detection of white matter degeneration of the visual pathway via diffusion-weighted MRI Daniela Coutiño, Judith Guerrero, César Domínguez-Frausto, Marlene Garcia-Guillén, Ricardo Coronado-Leija, Erick Hernández-Gutiérrez, Maxime Descoteaux, Martin Ayala, Mariana Badillo, Luis Concha Universidad Nacional Autonoma de Mexico, Queretaro, Mexico Impact: This study reveals that advanced methods for dMRI can noninvasively detect axonal degeneration in regions with crossing fibers (optic chiasm) and correlate with clinical parameters. This can extend for other regions with complex fiber configuration and different neurodegenerative diseases.