Teasing Out the Microstructure of the Brain and Nervous System
Oral
Neuro B
Wednesday, 13 May 2026
This session pulls together techniques to image or validate the microstructure of the brain and nervous system.
| 13:40 |
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505-03-001.
Enabling clinical submillimeter FLAWS imaging at 7T with subject-specific dynamic parallel transmit and motion correction
Impact: Equipped with individually tailored
pTx pulses, incoherent undersampling, and a deep
learning-based reconstruction, the proposed FLAWS sequence delivers a
high-resolution fluid
and white matter suppressed contrast along with a
reliable T1-weighted anatomical image, benefiting several clinical
applications at 7T.
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| 13:51 |
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505-03-002.
Cortical myeloarchitectural types in a 75μm isotropic whole human brain ex-vivo dataset
Impact: In ex-vivo, whole human brain data at 75μm isotropic, we show T2* contrast delineates all Vogt&Vogt striate types of myeloarchitecture. This presents an important step towards a whole-brain MRI-based atlas of laminar T2* contrast with close relationship to myeloarchitecture.
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| 14:02 |
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505-03-003.
Mapping the human anterior olfactory nucleus at 7 T using high-performance gradients: Preliminary results of the 7AON study
Impact: Provides the first in vivo, multimodal 7T MRI reference of
the human anterior olfactory nucleus, opening new opportunities for
quantitative and longitudinal mapping of olfactory network changes in aging and
neurodegenerative disease.
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| 14:13 |
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505-03-004.
3D multiscale characterization of qMRI Parameters in resected human hippocampal tissue using X-ray Phase-Contrast Tomography
Impact: Our novel multimodal-multiscale pipeline achieved voxel-wise registration of ultra-high-resolution X-ray tomography (650µm voxelsize) and qMRI. Our approach directly links microstructural features (like cell density and axons) to qMRI contrasts, offering a crucial 3D ground truth validation roadmap for neurological pathologies.
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| 14:24 |
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505-03-005.
Modelling the impact of white matter hyperintensities on normal appearing white matter
Impact: We investigate how white-matter hyperintensities (WMH) affect surrounding “normal”-appearing white matter (NAWM). A broad range of microstructural abnormalities were detected depending on the distance to the nearest WMH, supporting WMH as indicators of diffuse microstructural degeneration and discrete focal damage.
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| 14:35 |
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505-03-006.
Altered Thalamic Soma and Neurite Microstructure in Migraine with Aura on High-Gradient Diffusion MRI
Impact: We investigated thalamic microstructural alterations in patients of migraine with aura using soma and neurite density imaging on the high-gradient performance MRI system. Findings revealed region-specific neuronal-glial remodeling, advancing our understanding of migraine pathophysiology at the cellular level.
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| 14:46 |
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505-03-007.
Visualization of the Extra-Foraminal Cadaveric Vagus Nerve on Submillimetric CISS MRI: SPARC-REVA Study
Impact: MRI visualization of the vagus, cranial nerve X, could be used to direct future interventions including potential percutaneous MRI-guided procedures. Cadaveric imaging can help optimize acquisitions for future in vivo translation.
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| 14:57 |
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505-03-008.
In-vivo Axonal Diameter Mapping at 400 mT/m with Next-Generation Gradient Driver Technology on a High-Performance Gradient.
Impact: Combining innovations in gradient coil design and high-efficiency driver topology enables mesoscale modeling with enhanced sensitivity to previously elusive contrasts—like effective intra-axonal radii. These advancements unlock novel biomarkers and demonstrate a scalable path toward improved clinical diagnostics and therapeutic monitoring.
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| 15:08 |
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505-03-009.
In Vivo Conductivity Tensor MRI Reveals Ionic Microenvironment Alterations in Alzheimer’s Disease
Impact: Conductivity Tensor Imaging (CTI) enables mapping of compartment-specific ionic alterations in Alzheimer’s disease, revealing ionic dysregulation before structural atrophy becomes evident. CTI provides a quantitative, noninvasive biomarker linking cellular ion homeostasis to neurodegenerative progression, potentially improving early diagnosis.
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| 15:19 |
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505-03-010.
Mapping glioma microstructure and histopathological correlates using the TRACED diffusion model
Impact: The TRACED diffusion model provides a novel strategy for quantifying tumor microstructure. In multiple glioma patients, TRACED maps show sensitivity to infiltrative tumor borders and suggest persistence of high-cell fraction regions after treatment. Parameters show promising agreement with histopathology.
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