Heart and Brain Axis
Digital Poster
Cardiovascular
Tuesday, 12 May 2026
measuring brain and heart motion and flow and their interaction
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462-03-001.
Associations of Cerebral Arterial Pulsatility and Damping with Vascular Dysfunction, Amyloid Pathology, and Cognitive Decline
Impact: Phase-contrast MRI-derived flow pulsatility
metrics, including pulsatility index (PI) and damping factor (DF), can be
useful indicators of vascular dysfunction linking cardiovascular risk with
amyloid pathology and cognitive impairment, which may serve as sensitive
biomarkers for studying AD pathology.
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462-03-002.
MRI in Clinical Practice: Diagnosis of Cardiovascular and Cerebrovascular Diseases through Integrated Neuro-Cardiac MRI
Impact: Integrated neuro-cardiac MRI streamlines diagnostic workflows, reduces patient burden, and enables simultaneous evaluation of brain, heart, and vascular pathology, facilitating early intervention, personalized secondary prevention, and optimized management for patients with hypertension or at risk of stroke.
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462-03-003.
Disease-Specific Alterations in Cortical Morphometry and Heart-Brain Correlations in Dilated and Hypertrophic Cardiomyopathy
Impact: This
study reveals distinct cortical alteration patterns in DCM and HCM, providing
novel neuroimaging evidence for the heart-brain interactions.
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462-03-004.
Variability of Cerebral Flow Response to Oral Fluid Intake using Dual-VENC 4D-Flow-MRI
Impact: Variability
in cerebral flow following oral hydration reveals that individual physiological
responses can influence quantitative 4D-Flow-MRI measurements. Standardizing
pre-scan hydration may substantially improve reproducibility and
interpretability in neurovascular hemodynamic studies.
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462-03-005.
The Association of Cardiac Morphology and Function with Brain Structure and Cognitive Function: A Population-Based Study
Impact: This study elucidates the
heart-brain axis by linking the LV indices to brain structure and cognitive
function. The absence of mediation by brain volume suggests alternative
neurovascular or metabolic pathways underlying cardiovascular-related cognitive
impairment in aging populations.
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462-03-006.
Caffeine Shifts Brain-Body Coupling Dynamics During Mental Effort: A Multimodal EEG-fMRI Study
Impact: This study demonstrates the role of caffeine in
transitioning brain-body interactions from bidirectional to cortical-dominant
coupling during cognitive tasks. Findings inform caffeine timing for
cognitive performance and establish a framework for investigating how
pharmacological arousal modulates directionality in
clinical contexts.
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462-03-007.
Retrospective Cardiac-Resolved 4D Flow MRI of Cerebrospinal Fluid Dynamics under Different Respiratory States
Impact: This study
demonstrates the feasibility of retrospective 4D flow MRI for characterizing
CSF flow dynamics and highlights its potential to provide physiologically relevant,
cardiorespiratory driven CSF flow information for advancing research and
clinical evaluation of brain fluid circulation.
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462-03-008.
Deep Breathing Modulates Intracranial Compliance, A Non-invasive RT-PC MRI Approach for Compliance-like Quantification
Impact: A single-breath RT-PC paradigm enables
dynamic, non-invasive assessment of intracranial volume coupling. The
ΔCBV/ΔCSFV ratio serves as a compliance-like index, offering a rapid and
repeatable approach to probe brain compliance modulation under physiological
perturbation.
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462-03-009.
Posture Dependence of Cerebral Spinal Fluid and Blood Flow by Phase Contrast MRI at 3T
Impact: Our findings suggest a close coupling between blood flow and CSF
dynamics and a reduction of CSF circulation during prone versus supine posture.
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462-03-010.
Preliminary Protocol Sensitivity Analysis of Quantitative Amplified MRI
Impact: Insight of protocol design and motion mitigation for reliable quantitative-amplified MRI. Implementing recommended in situ acquisition guidelines can minimize non-physiological displacements and inform on data quality.
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462-03-011.
Poroelastic Inversion of the Human Brain at 3T using Amplified MRI
Impact: Integrating aMRI displacements with poroelastic inversion enables quantitative brain mechanics at cardiac frequencies without external drivers. Further refining inversion stability and validating against MRE could provide clinically relevant stiffness maps, informing cerebrovascular‑brain coupling, and biomarker development in low resource settings.
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462-03-012.
Multi-Modality and Multi-Variable Assessment of Intracranial Flow and Motion in Chiari I Malformation: A Preliminary Study
Impact: The
multi-modality, multi-variable data can provide a basis for better
understanding CMI and for parameterizing physical and computational models.
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462-03-013.
Alterations in Neurovascular Coupling in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
Impact: This study demonstrated impaired whole-brain
neurovascular coupling and abnormal regional CBF/fALFF ratios in MTLE-HS,
providing novel clues for deciphering the pathological mechanisms from the
interaction between cerebral blood perfusion and local neural activity.
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462-03-014.
CSF flow is driven by carotid stroke volume during inspiration and IJV flow during deep breathing
Impact: CSF flow is affected by respiration. We show that normal and deep inspiration both change CSF flow and show evidence that both decreased carotid stroke volume and increased IJV flow during inspiration drive this flow change.
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