Magnetization Transfer and Relaxometry
Digital Poster
Contrast Mechanisms
Wednesday, 13 May 2026
This session presents recent advances in magnetization transfer and relaxometry, including methodological developments and emerging applications.
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569-06-001.
Reproducibility of advanced Multi-Parameter-Mapping with ihMTsat using segmented 3D-EPI at 7T
Impact: Segmented 3D-EPI–based MPM and ihMTsat at 7T enable rapid whole-brain myelin-related mapping. PD and R1 show high reliability, ihMTsat offers increased myelin specificity but reduced stability compared to MTsat, emphasizing the need for further research to address inherent limitations.
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569-06-002.
Sensitivity of literature T1 mapping methods to the underlying magnetization transfer parameters
Impact: Understanding the biophysical underpinning of T1-abnormalities—by virtue of T1's sensitivity to the underlying magnetization transfer parameters—aids comparisons between T1 mapping sequences and clinical studies using them.
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569-06-003.
Spatial variations of macromolecular and transverse relaxation properties across the substantia nigra
Impact: Our work suggests that neuromelanin-sensitive MT contrast likely reflects lower
macromolecular or higher free-water fractions rather than neuromelanin itself. Quantitative
multimodal imaging characterization of the SN reveals biologically
heterogeneous subregions and may be employed to delineate nigral subnuclei in
vivo.
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569-06-004.
Elementary Steps of Magnetization Transfer at the Lipid-Water Interface as Observed by High-Resolution MAS NMR
Impact: HR-MAS NMR spectroscopy allows for the
direct visualization of elementary magnetization transfer steps at the
water-lipid bilayer interface on a molecular level. This clarifies the role of
the hydroxyl group in MT.
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569-06-005.
Pulsed Off-Resonance MT with Intrinsic Blood Suppression: Modeling with an Extended EPG Framework and Experimental Results
Impact: This work introduces an extended EPG simulation framework and a compact pulsed MT approach that inherently suppresses blood signal and enhance MT contrast without added sequence complexity, potentially improving MT imaging in highly vascular organs such as the liver.
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569-06-006.
Curved ZTE Spokes Enable Quiet and Efficient MT Ratio Imaging
Impact: Reducing acoustic noise in MRI enhances patient comfort and accessibility. Our silent MTR sequence enables clinicians and
researchers to assess myelination across diverse populations, including children and
individuals who are sensitive to scanner noise.
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569-06-007.
Iron sensitivity of longitudinal and transverse relaxation rates in the post-mortem human brain
Impact: Post-mortem quantitative MRI demonstrates that $R_2^*$ robustly reflects tissue iron concentration, while $R_1$ shows weaker and structure-dependent associations. These findings highlight the complexity of longitudinal relaxation mechanisms and question the reliability of $R_1$ as an iron-sensitive measure in brain tissue.
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569-06-008.
Multi-echo unbalanced steady state relaxometry via optimization of extended phase graph signal model with T2*
Impact: An updated signal model for unbalanced steady-state imaging enables single acquisition relaxometry, laying the foundation for future work in quantitative mapping using these sequences.
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569-06-009.
Model-Based Deep Learning Reconstruction for Highly Accelerated Submillimeter T2* Mapping at 7T
Impact: This study demonstrates the efficacy of model-based reconstruction
for highly accelerated acquisitions, enabling 0.6 mm
isotropic $T_{2}^*$ mapping of the brain in under 3.5 minutes at 7T, thus
allowing submillimeter resolution $T_{2}^*$ contrast at clinically compatible
scan times.
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569-06-010.
Evolution of Age-Related Brain Iron Accumulation Studied By Quantitative MRI
Impact: We demonstrate the utility of R2* mapping for noninvasive quantification of brain iron across the lifespan and between species. The results provide insights into the evolution of brain iron accumulation, a key factor in human brain aging.
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569-06-011.
Subject-Specific Normative Modeling and Voxel-Wise Quantification of Manganese Clearance Dynamics in the Human Brain
Impact: We
developed an individualized, voxel-wise quantification of brain manganese clearance
using quantitative MRI. It enables standardized regional kinetic analysis,
improves sensitivity to subtle recovery, and can be extended to
multi-parametric mapping of manganese, iron, gadolinium, and other contrast
agents.
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569-06-012.
Imaging of brain tumour invasion at Ultra-Low field by Field-Cycling Imaging: ex vivo Clinical Validation
Impact: Ultra-low-field
using FCI technology reveals glioma invasion and peritumoural regions from ex
vivo samples and in vivo patients. This may address an unmet
clinical need by guiding surgical and therapeutic strategies to be improved
through targeting of the peritumoural region.
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569-06-013.
Interactive effects of Ferumoxytol and gadolinium-based contrast agents in agar and saline phantoms
Impact: This
study provides a quantitative assessment of dual-contrast agent MRI, showing
that gadolinium and ferumoxytol interact non-linearly in relaxivity behaviour.
Understanding their interaction helps to guide optimization of in vivo
dual-agent imaging protocols.
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569-06-014.
Full-Passage Adiabatic Pulse Correction for Artifact-Free Spine T1rho Imaging
Impact: The stretched-type AFP T1rho pulse significantly improves robustness to B₀ and B₁ inhomogeneities, enabling nearly artifact-free spine imaging for clinical applications, including potential for use postoperatively in patients with metal implants.
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569-06-015.
Magnetic Resonance Fingerprinting for Characterization of Mediastinal Masses: A Feasibility Study
Impact: Diagnostic
uncertainty in mediastinal masses remains substantial, often leading to
unnecessary surgery or delayed treatment. Magnetic resonance fingerprinting
provides quantitative T1 and T2 mapping that may enhance noninvasive
differentiation of benign and malignant masses, improving diagnostic confidence patient management.
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569-06-016.
Variable T1 in deep brain stimulation targets requires patient-specific optimization of inversion recovery protocols at 7T
Impact: Deep brain stimulation requires accurate,
patient-specific visualization of target nuclei. However, their visibility on inversion-recovery
contrasts differs across patients. We demonstrate that this can be explained by
varying T1-values, suggesting that visualization can be improved through individualized
synthetic inversion contrasts.
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