Brain Physiology and Pain
Digital Poster
Brain Function & fMRI
Tuesday, 12 May 2026
Digital poster session with a dual topic: pain and brain physiology
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460-01-001.
Whole-brain cerebrovascular reactivity mapping at 10.5 Tesla
Impact: Demonstrated feasible at 10.5 T, whole-brain cerebrovascular reactivity
mapping without hypercapnia challenges using resting-state or intermittent
breath-modulation BOLD fMRI is believed to hold broad utility for human
neuroscience, facilitating accurate fMRI interpretation while detecting subtle
cerebrovascular changes due to aging.
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460-01-002.
Assessing the Minimum Number of Breath-Holds Required for Stable CMRO₂ and OEF Estimates Using Breath-Hold Calibrated fMRI
Impact: This
study demonstrates the potential for rapid, low-burden estimation of grey matter
CMRO2 and OEF using a reduced number of breath-holds in a calibrated
fMRI technique, supporting the feasibility of streamlined methods for future
clinical use and cerebral metabolic research.
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460-01-003.
Relationship between resting-state BOLD functional connectivity and baseline cerebrovascular physiology
Impact: Our study demonstrates that baseline CBF and CVR influence BOLD-FC, potentially confounding its reliability and interpretation across populations. Interestingly, these correlations disappear when CVR is examined with ASL instead of BOLD.
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460-01-004.
The Beating Brain: Frequency Shifts and Power Changes in Cardiorespiratory Rhythms during Motor Activation
Impact: By integrating accelerated EPI with ASL perfusion MRI, this study links intrinsic cardiac- and respiratory-driven fluctuations with cerebral perfusion. The approach provides a framework for exploring how physiological coupling and neurovascular regulation jointly shape perfusion dynamics in health and disease.
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460-01-005.
Using calibrated BOLD to measure transient changes in the metabolic rate of oxygen: comparing CBF-venous CBV coupling models
Impact: We established that the Windkessel model with
stiffness and viscoelastic coefficients more accurately estimates CMRO2
with calibrated BOLD than the Grubb relationship. This may allow for CMRO2
dynamics to be more fully understood under a range of conditions, like
resting-state.
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460-01-006.
Dual-acquisition calibrated fMRI improves CMRO₂ and CBF/BOLD coupling in resting state compared to conventional dual-echo ASL
Impact: Studying resting-state beyond BOLD provides richer insight into brain physiology. A novel dual-acquisition calibrated fMRI sequence showed more reliable multimodal functional connectivity and CBF/BOLD coupling than a standard dual-echo ASL, supporting its potential for future calibrated fMRI resting-state studies.
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460-01-007.
Thalamic Iron Deposition and Oxygen Metabolism Reflect Consciousness Levels after Traumatic Brain Injury: A QSM Study
Impact: Quantitative susceptibility mapping revealed that thalamic magnetic susceptibility and oxygen extraction fraction are linked to consciousness levels after traumatic brain injury, suggesting their potential as imaging biomarkers for assessing neuropathological mechanisms and prognosis in post-traumatic disorders of consciousness.
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460-01-008.
Longitudinal Changes in Brain Functional Connectivity Following Spinal Injections for Chronic Low Back Pain
Impact: This work links pain relief after spinal injections to brain network reorganization, advancing understanding of central pain modulation and identifying potential imaging biomarkers of treatment response.
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460-01-009.
The EEG-CMRO2 association and its implications for resting-state fMRI
Impact: EEG power and coherence are linked to CMRO2, CBF, and OEF in a sex-dependent manner, while metabolism and hemodynamics partially mediate EEG–fMRI associations, highlighting the necessity of multimodal approaches to fully understand neuronal and hemodynamic contributions to resting-state connectivity.
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460-01-010.
Altered Salience–Frontoparietal Network Dynamics in Vestibular Migraine: A Dynamic ICA Study
Impact: This study identifies dynamic network biomarkers for vestibular migraine, suggesting new targets for neuromodulation therapies. It enables future research into how network flexibility influences symptom chronicity and treatment response.
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460-01-011.
Resting-State fMRI Biomarker of Primary Headache and Its Modulation by Osteopathic Therapy
Impact: OMT increased connectivity within pain-related brain regions in individuals with primary headaches, shifting network organization toward healthy patterns. These findings enhance understanding of OMT’s neural effects and support its potential as a targeted, non-pharmacological approach for restoring normal pain-network function.
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460-01-012.
Mechanical Pressure Pain Evokes Predominantly Phasic Onset Responses Across Brain and Spinal Cord
Impact: Mechanical pressure pain evokes primarily phasic onset
responses across brain and spinal cord, and recovering their temporal dynamics
requires appropriately timed FIR-style analyses that standard boxcar-plus-HRF
models smear or entirely miss.
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460-01-013.
Pain and Cognitive Performance in Fibromyalgia: A Simultaneous Brain-Spinal Cord fMRI Study
Impact: We revealed that higher clinical pain intensity is associated with lower cognitive performance and cortical activity in fibromyalgia patients. Decreased corticospinal connectivity during a working memory task provide new insights on the neural substrates of pain-related cognitive impairments in fibromyalgia.
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460-01-014.
The Science of Calm: Functional connectivity insights into ASMR and Meditation for Well-being
Impact: Integrating Autonomous Sensory Meridian Response (ASMR) and meditation findings shows these relaxation practices engage distinct yet convergent neural systems—meditation emphasizing introspective regulation and ASMR emphasizing sensory–reward processing. This dual mechanism offers new perspectives for personalized stress and emotional regulation strategies.
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