Novel Neuro Applications
Digital Poster
Neuro B
Wednesday, 13 May 2026
This session presents a variety of cutting-edge MRI applications in the brain across species.
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563-01-001.
Development of Interactive MRI-derived Visualization Tools for Neuroanatomy Education in Latin America
Impact: The developed tools provide a resource for neuroanatomy education in Latin America, and the work explores initial real-world application of these tools in an undergraduate neuroscience program. It is hoped this can encourage further exploration of educational MRI-based visualization tools.
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563-01-002.
Training 105 African clinicians and students in open neuroimaging analysis: CAMERA’s dementia research program
Impact: CONNExIN is training a cohort of African researchers to analyze brain MRI data and become local experts capable of training others, thereby strengthening dementia imaging research capacity in low- and middle-income countries (LMICs).
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563-01-003.
Whole-brain 3D high-resolution elastography in mice reveals early changes during AD progression
Impact: Whole-brain MRE with high-resolution in 5XFAD mice showed a significant
cortical stiffness reduction during early AD progression, correlating with
greater Aβ deposition in cortex. This suggests MRE could
serve as a biomarker for early detection of AD.
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563-01-004.
Changes in White matter and total vessel volume are linked to treatment remission in major depressive disorder
Impact: Antidepressant therapy
induced WMV changes in frontal, cingulate, temporal regions along with changes
in total vessel volume, can serve as early response markers. Such differences
between remitted and non-remitted major depressive disorder patients suggest distinct
pathophysiology in these two subgroups.
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563-01-005.
Sodium T2 relaxation-based signal separation in mild TBI: looking at potential sodium MRI biomarkers of injury
Impact: Pilot data suggest that the MSQ separation technique may provide added specificity for detecting subtle ionic changes in mTBI and establishes as a highly sensitive, cellular-level biomarker for early or subtle neurotrauma, paving the way for improved assessment of mTBI.
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563-01-006.
Anatomical brain MRI characterization of the Ts66Yah mouse model of Down Syndrome and effects of in utero DYRK1A inhibition
Impact: Prenatal inhibition of DYRK1A with LCTB21
induces shared and genotype-specific gray-and white matter modulations in
Ts66Yah and wild-type mice, revealing coordinated neurodevelopmental remodeling
and highlighting DYRK1A’s central role in shaping early brain structure across
genotypes.
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563-01-007.
Integrative Analysis of Cortical Morphometric Similarity Network and its Genetic Associations in Epilepsy of Unknown Etiology
Impact: This work elucidates
epilepsy of unknown etiology represents a network disorder characterized by
widespread cortical microstructural disruption. These findings provide
preliminary genetic evidence linking macroscopic network alterations in
early-onset patients, offering novel insights into the pathophysiological
mechanisms underlying this condition.
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563-01-008.
Improved Monitoring of Injectable Biomaterial Implants in Rats Using Dixon-TurboRARE MRI at 9.4T
Impact: Volumetric assessment is critical for implant studies in rat models. Results showed that caliper measurements systematically overestimated implant size, whereas Dixon-based MRI with automated segmentation (SAM) achieved high accuracy and reproducibility, establishing a standardized preclinical imaging framework with translational value.
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563-01-009.
Spatiotemporal Subtyping of Structural Progression in Hippocampal Sclerosis Using SuStaIn and Volumetric Biomarkers
Impact: Volumetric
SuStaIn reveals biologically and clinically relevant HS subtypes characterized
by divergent atrophy patterns, providing critical insights for preoperative
evaluation and the development of individualized therapeutic strategies.
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563-01-010.
Rapid Visualization of the Human Locus Coeruleus at 7T Using CUBE Imaging
Impact: At 7 T MRI, by reducing SAR through CUBE implementation and accelerating acquisition with longer ETL, this study visualized the extremely small and difficult-to-visualize human locus coeruleus in just over two minutes-less than half the scan time of previous studies.
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563-01-011.
Subtype-Specific Locus Coeruleus Degeneration Across Parkinson’s Disease and Multiple System Atrophy on NM-MRI
Impact: Standardized NM-MRI revealed subtype-specific locus coeruleus degeneration across PD and MSA, linking LC integrity with cognitive, motor, and autonomic symptoms. These findings support LC contrast as a reproducible biomarker for disease differentiation and noradrenergic dysfunction monitoring.
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563-01-012.
Reversible Ventral Brainstem Alterations in Chronic Kidney Disease: Voxel-based Morphometry Evidence for Uraemic Brain Injury
Impact: This study identifies reversible ventral brainstem voxel-based morphometry changes as potential imaging biomarkers of uraemic brain involvement in chronic kidney disease, linking apparent post-dialysis normalisation with persistent attentional slowing and offering insights for neuroprotective strategies and monitoring in haemodialysis patients.
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563-01-013.
In Situ Postmortem 7 Tesla MRI of Nigral Iron in Parkinson’s Disease: A Histopathologically Validated Study
Impact: This unique ultra-high-field post-mortem 7 tesla in situ quantitative susceptibility mapping study enabled assessement of nigral iron that aligned with histology. While histopathological validations aligned with expected nigral subregional segmentation patterns using QSM, the small sample size limited statistical power.
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563-01-014.
Brainstem Mapping in Parkinson’s Disease with and without Apathy Using MP2RAGE‑FLAWS MRI at 3T
Impact: This study identifies specific brainstem nuclei as potential imaging biomarkers of apathy in Parkinson’s disease, enabling earlier diagnosis and targeted interventions, and paving the way for future research on brainstem‑limbic network dysfunction and treatment response monitoring.
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