Impact: Using QSM and ASL MRI, this study establishes a quantitative link between obesity and brain health. It reveals hidden pathological processes to lay the foundation for preventing obesity-related cognitive decline.

Impact: Obesity may cause functional disruption in the left hippocampus and inferior parietal lobule networks, which are important components of the DMN. The regional fat deposition poses an additional threat to alterations of functional connectivity in the left inferior parietal lobule.

Impact: This study reveals trans-synaptic degeneration in DON, demonstrating that optic nerve damage correlates with optic radiation injury. DTI parameters serve as sensitive biomarkers for disease progression, encouraging future neuroprotective strategies targeting the entire visual pathway.

Impact: Obesity-linked hypo-perfusion in right mid-frontal gyrus and hyper-perfusion in left putamen/right ACC uncover neural correlates of cognitive decline, informing early imaging biomarkers and targeted metabolic-neuroprotective therapies.

Impact: This study reveals that pain catastrophizing modulates IBS symptoms through brain–spinal integration, highlighting cognitive targets for treatment and providing a novel imaging framework to investigate top-down modulation mechanisms in chronic visceral pain disorders.

Impact: Our findings indicated the chronification of LBLP involved a fundamental shift from metabolic stress-driven sensorimotor reorganization to synaptic plasticity-mediated multi-network remodeling, providing a new perspective on the mechanisms underlying pain chronification and establishing a theoretical basis for developing stage-specific interventions.

Impact: Our study suggested the value of hippocampal functional radiomics features for distinguishing cognitively impaired from cognitively preserved low back related leg pain (LBLP) patients and may assisted in developing more appropriate and effective treatment plans for cognitively impaired LBLP patients.

Impact: Our findings reveal the pivotal role of the choroid plexus in connecting age-related hearing loss with cognitive decline, offering a novel target for early detection and intervention.

Impact: MEGA-PRESS technique can quantitatively evaluate changes in GABA metabolism, correlating with pain reduction in HZN. GABA may serve as an imaging biomarker for treatment response, and the right insular cortex as a pivotal therapeutic target.

Impact: Multimodal MRI identifies OFC–thalamus abnormalities linked to stress symptoms and medication variability, offering practical biomarkers for early risk screening and targeted interventions to support adherence and graft survival in kidney transplant recipients.

Impact: Gradient mapping may serve as a novel biomarker for brain network reorganization and cognitive variability in thalassemia.

Impact: By revealing directional alterations in interregional connectivity associated with cognitive deficits after carbon monoxide poisoning, this study provides mechanistic insight into disrupted brain communication and identifies potential targets for future neuromodulatory and rehabilitative interventions for ACOP patients.

Impact: This study reveals training-induced neuroplasticity in soccer players, showing enhanced effective connectivity within and between the DMN and DAN. Findings highlight adaptive neural reorganization supporting cognitive-motor demands and suggest EC metrics as biomarkers of athletic expertise in complex, open-skill sports.

Impact: The WM dysfunction in ESRD patients is driven by the concomitant effects of vascular injury and neurodegeneration, providing insight into the neurobiological underpinnings and holding potential implications for clinical management and therapeutic interventions in ESRD.

Impact: These findings suggest that neurovascular-metabolic dysfunction in CKD is not strictly irreversible. Long-term hemodialysis may promote partial recovery of perfusion–metabolic coupling in memory- and cognition-related structures, in parallel with cognitive improvement.

Impact: We implemented the SLice-Oriented MOtion COrrection (SLOMOCO) method in the HCP pipeline. SLOMOCO-preprocessed datasets reduced motion effects on functional connectivity and revealed sex differences. The developed SLOMOCO scripts, plugged in HCP pre-processing pipeline is publicly available.