Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Cancer Imaging and Spectroscopy

Oral

Preclinical

Wednesday, 13 May 2026

Ballroom East

16:00 - 17:50

Moderators: Harish Poptani & Anant Patel

Session Number: 504-04

CME/CE Credit Available

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This oral session will cover MR-based cancer detection and treatment responses, as well as radiation-induced injuries, using preclinical models.

16:00		504-04-001. Nitric Oxide–Induced Methemoglobin as an Endogenous and Autologous MRI Perfusion Contrast Agent at 3T Shiman Wu, Xiaozhu Hao, Pu-Yeh Wu, Zonglin Liu, YAN REN, Zhenwei Yao Hushan Hospital, Fudan University, Shanghai, China Impact: This study introduces the first blood-derived, fully endogenous MRI perfusion contrast method. Nitric oxide–induced methemoglobin (NOCA) provides strong susceptibility effects and intravascular specificity without gadolinium or nanoparticles, offering a promising, safe alternative for quantitative perfusion imaging and clinical translation.
16:11		504-04-002. Integrated Metabolic and Imaging Assessment of mTOR Inhibition by Torin2 in Diffuse Large B-Cell Lymphoma Pradeep Kumar Gupta, Shengchun Wang, Mamta Gupta, Shilpa Rao, Aria Osborne, David Rushmore, David Nelson, Johnvesly Basappa, Mariusz Wasik, Kavindra Nath University of Pennsylvania, Philadelphia, United States of America Impact: ¹H-MRS-detectable metabolites, including lactate, alanine, choline, and taurine, serve as effective biomarkers of mTOR inhibition. This study supports use for noninvasive monitoring of therapeutic response in diffuse large B-cell lymphoma (DLBCL) and highlights its potential in advancing precision metabolic imaging.
16:22		504-04-003. Deuterium MR Spectroscopy of tumor models to examine their balance in glycolytic and oxidative metabolism Andor Veltien, Jack van Asten, Eva Berkhout, Sandra Heskamp, Daan Boreel, Arend Heerschap Radboud University Medical Center, Nijmegen, Netherlands Impact: For this study, 3 types of tumors in increasing glycolytic vs oxidative balance were studied. Deuterium Metabolic Spectroscopy was used to measure the tumor glycolytic flux, a marker for the balance in glycolytic vs oxidative tumor metabolism.
16:33		504-04-004. Evaluation of Chemotherapy Response Using Hyperpolarized ¹³C MRI in PDX Models of Metastatic Prostate Cancer Meetu Wadhwa, Said Al Muzahimi, Ivina Mali, Rosalie Nolley, Andrea Capozzi, Sule Sahin, Jennifer Lewis, Peder Larson, John Kurhanewicz, Donna Peehl, Renuka Sriram University Of California, San Francisco (UCSF), United States of America Impact: Despite similar tumor volume changes after carboplatin treatment, k_PL evolves differently across metastatic sites, highlighting the need to understand therapy-induced microenvironmental differences and their impact on imaging metric quantification (k_PL) for effective clinical translation.
16:44		504-04-005. QSM Evaluates the Antifibrotic Efficacy of Bufalin and Pirfenidone in a Mouse Model of Hepatocellular Carcinoma Yongkang Ma, Pu-Yeh Wu, Jianqi Li, Shuohui Yang Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China Impact: QSM provides a non-invasive, quantitative MRI biomarker for evaluating antifibrotic therapy in HCC, enabling longitudinal monitoring of tumor microenvironment remodeling.
16:55		504-04-006. ¹H-MRS in a Mouse Model of Pancreatic Ductal Adenocarcinoma: Tentative Assignment of Seven Lipids and Twelve Metabolites Diana G. Rotaru, Yanping Sun, Emma Van Praagh, Albrecht Schmid, Russell Posner, Stephen Sastra, Carmine Palermo, Michael Badgley, Daniel Ross, Christoph Juchem, Kenneth Olive Medical University of Vienna, Vienna, Austria Impact: Previously unreported lipids and metabolites were tentatively identified in in vivo pancreatic cancer ¹H-MR spectra. Our findings equip researchers/clinicians with a robust, standardized framework that expands ¹H-MRS capabilities and advances in vivo metabolic profiling in preclinical/clinical pancreatic research.
17:06		504-04-007. Amine-CEST MRI with Gadolinium Contrast Differentiates Tumor Progression from Pseudo-progression/ Radiation Necrosis Blake Benyard, Narayan Datt Soni, Nishi Srivastava, Anshuman Swain, Junyoung Shin, RAVI PRAKASH REDDY NANGA, Nadir Yehya, Yi Fan, Ravinder Reddy, Mohammad Haris University of Pennsylvania, Philadelphia, United States of America Impact: This method has the potential to improve clinical decision-making, optimize treatment strategies, and reduce the need for invasive biopsies in brain tumor patients with post-radiation lesions.
17:17		504-04-008. Effects of brain irradiation on cerebral blood flow, BBB water exchange, vascular integrity, and recognition memory in mice Annet Nakkazi, Duncan Forster, Jennifer Fletcher, Douglas Dyer, Anthony Chalmers, Kaye Williams, Ben Dickie University of Manchester, Manchester, United Kingdom Impact: Understanding normal tissue effects following brain radiotherapy is critical to the management of brain cancer survivors. Our work highlights early and late neurovascular and immune cell changes which may drive cognitive dysfunction, highlighting key areas for future study.
17:28		504-04-009. Hyperpolarized metabolic 13C MR spectroscopy and imaging for differentiation of tumor xenografts in fertilized chicken eggs Miriam Kirst, Raphela Ranjan, Rubén Hernández-Vega, Sandra Sühnel, Nadine Setzer, Tobias Haase b. Lobmeyer, Luca Nagel, Geoffrey Topping, Robert Zürl, Alexander Weisser, Florian Odoj, Volker Rasche, Maximilian Reichert, Franz Schilling TUM School of Medicine and Health, TUM University Hospital, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany Impact: This study shows for the first time a comparison of hyperpolarized ¹³C metabolic MRI of patient-derived and murine tumor xenografts in fertilized chicken eggs. A refinement of the data extraction could yield further insights for metabolic profiling in personalized medicine.
17:39		504-04-010. MRI/MRS Measures of Therapeutic Response in an Aggressive Rat C6 Glioma Model Treated with a Highly Effective Novel agent Abbas Khojasteh, Ralph Hurd, Laura Pisani, Meng Gu, Phil Adamson, Nikita Mishra, Niven Narain, Lawrence Recht, Daniel Spielman Stanford Medicine, Stanford, United States of America Impact: We demonstrate that BPM31510 (currently in Phase II human trials) achieves >90% long-term survival in a rat C6 glioma model, and MRS measures of brain creatine and lipid metabolism are better response predictors as compared to clinically used volumetric metrics.