Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Body, Cardiovascular, and Musculoskeletal Systems in Small Animals

Body, Cardiovascular, and Musculoskeletal Systems in Small Animals

Digital Poster

Preclinical

Tuesday, 12 May 2026

Digital Posters Row C

14:35 - 15:30

Session Number: 462-04

No CME/CE Credit

Similar Sessions

Preclinical, multiparametric MR evaluation of the body, cardiovascular, and musculoskeletal systems

		462-04-001. Swimming Attenuates Paraspinal Muscle Degeneration in Rats with Discogenic Low Back Pain: A Multimodal MRI Study Jiaqiu Jiang, Bo He, Lisha Nie Department of Medical Imaging，the First Affiliated Hospital of Kunming Medical University, Kunming, China Impact: Provides quantitative, noninvasive MRI markers of exercise-induced paraspinal muscle remodeling, enabling objective monitoring and mechanism-informed rehabilitation. These markers support responder stratification and dosing in trials and can be standardized across centers to accelerate clinical translation.
		462-04-002. Redox imaging of Duchenne muscular dystrophy in mdx mice using in vivo DNP-MRI Fuminori Hyodo, Hinako Eto, Elhelaly Abselazim, Shoya Shiromizu, Hirohiko Imai, Yoshifumi Noda, Hiroki Kato, Murata Masaharu, Masayuki Matsuo Gifu University, Gifu, Japan Impact: In vivo DNP-MRI using the redox probe CmP detected increased radical reduction in mdx mice, reflecting macrophage activity despite reduced mitochondrial content. This noninvasive imaging effectively evaluates local skeletal muscle inflammation in Duchenne muscular dystrophy.
		462-04-003. DTI FA/MD Quantify Cyr61–Wnt/β-Catenin Remodeling in Sarcopenic Rat Muscle xiaoling kui, Lisha Nie, Bo He Medical imaging department，First Affiliated Hospital of Kunming Medical University, Kunming, China Impact: DTI FA/ MD deliver a quantitative, noninvasive readout of Cyr61–Wnt remodeling (ECM expansion, slow-twitch shift). This guides go/no-go for anti-Cyr61/Wnt or anti-fibrotics, reduces biopsy burden, and supports dose selection and target engagement in sarcopenia trials.
		462-04-004. Multi-parametric qMRI of Quadriceps Muscle to Characterize Osteoarthritis in a Post-Traumatic OA Mice Model Shantanu Sinha, Sheronda Statum, Sophia Dwek, Kevin Burt, Yajun Ma, Aurea Borges, Carla Scanzello, Usha Sinha, Christine Chung University of California, Berkeley, United States of America Impact: Knee osteoarthritis (kOA) is a huge societal burden with no pharmaceutical treatments available; impairment in muscle quality may drive functional disability. Characterization of quadriceps muscle structural remodeling may lead to optimized rehabilitation strategies that may improve functional outcomes.
		462-04-005. Multimodal MRI with Superparamagnetic Nanoprobe Evaluates Bone Marrow Hypoxia and Type H Vessel Damage in Diabetic Rabbits Haoran Lei, Weiyin Vivian Liu, Yunfei Zha Renmin Hospital of Wuhan University, Wuhan, China Impact: This study establishes a non-invasive imaging platform for quantifying bone marrow hypoxia and type H vessel impairment in diabetic osteopathy. It provides crucial translational evidence for targeting the bone marrow microenvironment, enabling early intervention and personalized treatment strategies.
		462-04-006. DCE-MRI reveals age-related bone-marrow dysfunction in immunocompromised mice Ana Gomes, Dominique Bonnet, Bernard Siow The Francis Crick Institute, London, United Kingdom Impact: DCE-MRI revealed age-related bone marrow vascular dysfunction in NSG mice, specifically reduced vascular density and increased leakiness. These changes, influenced by sex, highlight sex-dependent vascular aging mechanisms in immunocompromised environments and may help guide future therapeutic strategies.
		462-04-007. 3.0T Multi-Parametric MRI Assessment of Knee Cartilage Degeneration and Its Molecular Correlates with β-Catenin and MMP-13 Muqing Luo, Weiyin Vivian Liu, Yinqi Liu, Mengtian Ma, Kun Zhang The First Hospital of Hunan University of Chinese Medicine, ChangSha, China Impact: The combined use of 3.0T T2 and T1ρ mapping enables quantitative, non-invasive evaluation of early knee cartilage degeneration while reflecting molecular changes in β-catenin and MMP-13. This approach shows significant potential for translational research and preclinical assessment of osteoarthritis interventions.
		462-04-008. Effects of ACL Transection on Articular Cartilage via Quantitative µMRI Rabbit Model Austin Tetmeyer, Amanveer Singh, Hannah Mantebea, Farid Badar, Michael Newton, Kevin Baker, Yang Xia Oakland University, Rochester, United States of America Impact: The results of this project provide evidence of early, zone-specific degradation of articular cartilage post-ACL injury, guiding others towards µMRI-based, non-invasive, early diagnostics for other types of injury-related osteoarthritis.
		462-04-009. Differential Effects of T2DM and HFD on Rat Body Tissues: A Quantitative mDixon-Quant Evaluation Jujia Li, Jian Zhao, Ying Liu, Ning Zheng, Qian Meng, Shuo Chen, Xiaojian Zhang Hebei Medical University Third Hospital, shijiazhuang, China Impact: The differential impact of hyperglycemic and high-fat diets on rat tissues exhibit distinct target organ specificity. It can be quantitatively assessed using mDixon-Quant-based imaging.
		462-04-010. In Vivo MRI Visualization of the Interstitial Fluid Flow outside of brain in the Vascular Adventitia Dong Wei, Juncen Wu, Wenchao Yang, Zijian Zhou, Hongyi Li, Peng Hu ShanghaiTech University, Shanghai, China Impact: This study provides in vivo MRI evidence that subcutaneously injected contrast flows along vascular adventitia—not within the lumen—confirming interstitial fluid movement around abdominal and lower-limb vessels.
		462-04-011. Assessment of Gas Exchange Function of the Lung in Anemia Using Hyperpolarized 129Xe MR Hongchuang Li, Haidong Li, Ming Zhang, xiaoling liu, Qi Chen, Xiuchao Zhao, Yeqing Han, Xin Zhou State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China Impact: This study demonstrated the feasibility of using¹²⁹Xe MRI to investigate the changes in local pulmonary gas exchange function during anemia, providing a new perspective for understanding the mechanisms underlying the relationship between anemia and pulmonary function alterations.
		462-04-012. Therapeutic Effects Assessment in Acute Lung Injury Using Hyperpolarized 129Xe Magnetic Resonance Yu Zheng, Haidong Li, Ming Zhang, xiaoling liu, Hongchuang Li, Mingyan Yu, Wenjie Wang, Jiawei Zhu, Xiuchao Zhao, Haofeng Li, Siya Wei, Yeqing Han, Xin Zhou State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences - Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, China Impact: These results demonstrate the potential of hyperpolarized ¹²⁹Xe MR as a non-invasive and sensitive selection for continued application in interventional studies on ALI
		462-04-013. Motion-robust keyhole-accelerated CEST MRI of fasting-induced biochemical remodeling in the liver Zoheb Ahasan, Samantha Condo, Victoria Laney, Weiguo Li, Kejia Cai University of Illinois Chicago, Chicago, United States of America Impact: This study establishes motion-robust CEST MRI as a noninvasive biomarker for hepatic metabolic remodeling, enabling spatially resolved monitoring of fasting and disease-related biochemical changes. It opens avenues for studying dynamic liver metabolism, fibrosis progression, and therapeutic response in vivo.
		462-04-014. Diffusion Kurtosis Imaging of Renal Microstructural Changes During Chronic Liver Disease Progression in Rats Jiaming Qin, Shuangshuang Xie, Chen Zhang, Wen Shen Nankai University, Tianjin, China Impact: As a noninvasive technique, DKI can detect renal microstructural injury during chronic liver disease progression, enabling early identification of renal damage before serum creatinine abnormalities and aiding timely protection to reduce chronic kidney disease risk.
		462-04-015. Preliminary results of novel ultra-small TiO2 nanoparticles with iron oxide on rats with acute and chronic kidney diseases Khallil Chaim, Mayara Uchiyama, Katia Neves, Robson Guimaraes, Victor Santana, Maria Heloisa Shimizu, Luzia Furukawa LIM44, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil Impact: A new design of ultra-small paramagnetic nanoparticles (UPNs) as contrast agents can be associated with different classes of molecules, conferring selectivity and other desirable properties for molecular diagnosis. The results indicate a promising use, including in patients with kidney disease.
		462-04-016. Predicting kidney disease progression due to AKI and assessing susceptibility to AKI using resting state MRI Edwin Baldelomar, Jennifer Charlton, Kevin Bennett Washington University School of Medicine, St. Louis, United States of America Impact: rsMRI of the kidney may allow the early detection of risk of CKD after AKI, and may be used to assess susceptibility to AKI in healthy subjects. rsMRI could enable noninvasive assessment of risk and disease after AKI in humans.