Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - Innovative Methods To Understand Stroke

Innovative Methods To Understand Stroke

Oral

Neuro A

Wednesday, 13 May 2026

Auditorium 1

08:20 - 10:10

Moderators: Scott McNally & Venkatagiri Krishnamurthy

Session Number: 503-01

CME/CE Credit Available

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This oral session comprises a comprehensive range of clinical MRI methods, aiming to understand ischemic stroke, utilising the state-of-the-art and leading-edge approaches.

Skill Level: Basic,Intermediate,Advanced

08:20		503-01-001. Imaging Cerebral Blood Perfusion and Oxygen Metabolism in Sickle Cell Disease Using Velocity Selective Arterial Spin Labeling Yanhua Chen, Aliyah Alick, Chenming Pu, Dan Zhu, Doris Lin, Qin Qin, Eboni Lance, Feng Xu Johns Hopkins University School of Medicine, Baltimore, United States of America Impact: Sickle cell disease increases the risk of stroke and other neurological complications. This study highlights the significance of employing hemoglobin type-specific methodologies to accurately assess cerebral blood flow, oxygen extraction fraction, and cerebral metabolic rate of oxygen.
08:31		503-01-002. Combination of Plaque Characteristics of Middle Cerebral Artery and Hemodynamics Reveals Mechanisms of Border-Zone Infarcts Shan-Shan Wu, Ling Wang, Xian Ru, Deng-Ling Zhao Zhongda Hospital, Medical School, Southeast University, Nanjing, China Impact: By integrating HRMR-VWI and CFD analysis, this study reveals distinct plaque characteristics and hemodynamic variations underlying IBZ and CBZ infarcts in symptomatic MCA stenosis, providing mechanistic insight into stroke pathogenesis and supporting individualized, mechanism-based prevention strategies.
08:42		503-01-003. Permeability changes measured by dynamic contrast enhancement and revascularization surgery in patients with moyamoya disease Shoko Hara, Misaki Miyasaka, Yosuke Ishii, Shihori Hayashi, Motoki Inaji, Kenji Ishii, Yoji Tanaka, Taketoshi Maehara Institute of Science Tokyo, Tokyo, Japan Impact: In patients with moyamoya disease, blood brain barrier (BBB) dysfunction may correlate with hemodynamic disturbances and be reversible after revascularization surgery. Further investigation is needed to clarify whether BBB dysfunction affects cognition in this disease population.
08:53		503-01-004. Evaluation of Cerebral Oxygen Metabolism in Patients with Carotid Steno-occlusive Disease by 3D Constrained Quantitative BOLD Kathryn Jaroszynski, Jeffrey Dennison, Christopher Favilla, Hyunyeol Lee, Felix Wehrli University of Pennsylvania, Philadelphia, United States of America Impact: This study illustrates the potential of constrained qBOLD MRI for clinical evaluation and characterization of steno-occlusive disease. CqBOLD showed reductions in CBF and increases in OEF in a small group of patients diagnosed with internal carotid occlusion or severe stenosis.
09:04		503-01-005. Investigating perfusion deficits in carotid artery stenosis: single- vs. multi-delay Arterial Spin Labeling MRI Gabriel Hoffmann, Lena Schmitzer, Matthias van Osch, Lena Vaclavu, Cornelius Berberich, Julia Ten Pas, Tim Bitter, Jens Göttler, Daniela Branzan, Jan Kirschke, Christine Preibisch, Stephan Kaczmarz Technical University of Munich, Munich, Germany Impact: Stenosis-induced reduced perfusion (CBF) can be reliably detected in high-grade stenosis either by single PLD or time-encoded multi-PLD pCASL. Between both, CBF_te-pCASL is the more sensitive marker, as it is also associated with stenosis degree and has reduced ATT bias.
09:15		503-01-006. MRI in Clinical Practice: NeuroMix-based fast MRI protocol can replace CT/CT angiography for emergent workup of dizziness. Hugo Decker, Richard Baron, Amy Bui, Ian Brown, Michael Losak, Ryan Ribeira, Andrew Stromberg, Katie Kvam, Neil Schwartz, Stefan Skare, Nancy Fischbein, Greg Zaharchuk Stanford University, Stanford, United States of America Impact: For dizzy patients in the Emergency Department, a fast MRI Brain and MRA protocol provides superior diagnosis over CT/CTA, improving patient management and outcomes by enabling definitive exclusion of stroke without increasing length of stay.
09:26		503-01-007. Better Plasticity is Dynamic: Cortical Thickness Trajectories Predict Post-Stroke Motor Recovery Jiayouzheng Li, Yi Shan, Yinshan Wang, Chongjing Luo, Jie Xu, Jing Liu, Xinian Zuo, Jie Lu Xuanwu Hospital, Capital Medical University, Beijing, China Impact: We reveal that post-stroke motor recovery is linked to dynamic cortical thickening, rather than a static high thickness, highlighting the need for longitudinal monitoring to guide therapies that promote beneficial structural plasticity.
09:37		503-01-008. Assessment of pulsatility in the aging brain with 3D amplified MRI Caitlin Neher, Tyson Lam, Fargol RezayAraghi, Mehmet Kurt University of Washington, Seattle, United States of America Impact: This study provides a novel, non-invasive assessment of pulsatile motion in the aging brain using high-resolution 3D amplified MRI. The results show signifcantly reduced pulsatility in the aging deep gray matter and preliminary indications of sex-specific displacement trajectories in aging.
09:48		503-01-009. Enhanced Detection of Neuroplasticity After Stroke Using Multi-Band fMRI and Lesion-Centered connectivity Modeling Himanshu Singh, Sparsh Singh, Vishnu V. Y., S Senthil Kumaran, Leve Joseph Devarajan Sebastian, Ajay Garg All India Institute of Medical Sciences, New Delhi, India Impact: This study shows that single-band and multi-band fMRI techniques capture distinct aspects of post-stroke neuroplasticity. Single-band fMRI identifies dominant recovery networks, while multi-band fMRI detects finer directional coupling. These methods provide comprehensive insight into lesion-driven reorganisation dynamics.
09:59		503-01-010. Multiparametric MR features of carotid atherosclerotic plaques using SQUMA: Insights into ischemic stroke risk Ning Xu, Shuwan Yu, Zihan Ning, Xihai Zhao Tsinghua University, Beijing, China Impact: This study explored the correlation between ischemic stroke and carotid artery T1-T2-T2* multi-parametric features of patients with carotid plaque. A multi-parametric feature system composed of single parameter features and joint parameters features were proposed.