Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition

Body Diffusion MRI

Oral

Diffusion

Wednesday, 13 May 2026

Auditorium 1

13:40 - 15:30

Moderators: Malwina Molendowska & Martijn Froeling

Session Number: 503-02

No CME/CE Credit

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This session highlights innovative methods and applications in microstructure measurements, covering a range of body applications in heart, liver, breast, kidney and prostate. Body diffusion MRI is challenging due to effects such as motion, distortion, eddy currents and more. In this session, methods for addressing these challenges are presented, alongside a range of exciting and novel applications for tissue microstructure mapping in the body.

13:40		503-02-001. In-vivo microstructural dynamics of the Hypoplastic Left Heart Pedro Ferreira, Sylvia Krupickova, Julieta Rancati, Melonie Johns, Andrea Freixa-Benavente, Alessandra Frigiola, Hannah Bellsham-Revell, Kuberan Pushparajah, Elettra Pomiato, Alberto Di Biase, Rick Wage, Camila Munoz, Andrew Scott, Sonia Nielles-Vallespin, Dudley Pennell Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom Impact: In-vivo cardiac diffusion tensor imaging revealed that in Hypoplastic Left Heart Syndrome, the systemic right ventricle adopts a left ventricle–like microstructure although with reduced sheetlet mobility, indicating impaired myocardial dynamics and potential long-term maladaptation.
13:51		503-02-002. Fat-removal Reconstruction for Improved Body DWI Fat Suppression Aidan Tollefson, Julius Heidenreich, Felix Schön, Orhan Unal, Ali Pirasteh, Diego Hernando University of Wisconsin - Madison, Madison, United States of America Impact: Fat suppression failure artifacts in body DWI are mitigated through a fat-removal reconstruction that improves visualization and diagnostic confidence. This parallel imaging-based post-processing approach serves as a practical complementary reconstruction for clinical exam interpretation.
14:02		503-02-003. Advanced Diffusion-Weighted Imaging Modeling to Predict Upstaging of Ductal Carcinoma In Situ to Invasive Cancer at Surgery Debosmita Biswas, Daniel Hippe, Dariya Malyarenko, Anum Kazerouni, Isabella Li, Vivian Youngjean Park, sara javid, Mark Kilgore, Savannah Partridge, Habib Rahbar University of Washington, Seattle, United States of America Impact: Advanced DWI models, particularly diffusion kurtosis and impeded diffusion fraction, were predictive of DCIS upstaging to invasive and superior to conventional ADC. Combining DWI with DCE features enhanced risk stratification, supporting imaging-based approaches to match treatment to biological aggressiveness.
14:13		503-02-004. Correlation of diffusion anisotropy measurements from phase-contrast micro-CT and DTI in prostate tissue Adam Phipps, Geoffrey Watson, Paul Sved, Benedicta Arhatari, Nyoman Kurniawan, Roger Bourne University College London, London, United Kingdom Impact: 3D phase-contrast micro-CT (MCT) imaging presents novel opportunities for investigating the structural determinants of diffusion behaviour in prostate tissue.
14:24		503-02-005. Eddy Current Compensated Diffusion-Encoded Preparation Module for Cardiac Diffusion Tensor Imaging Sandra Haltmeier, Maximilian Fuetterer, Limin Zhou, Christian Stoeck, Kevin Moulin, Sebastian Kozerke University Zurich and ETH Zurich, Zurich, Switzerland Impact: Diffusion-encoded preparation modules for cardiac diffusion tensor imaging increase signal-to-noise ratio by minimizing T₂-relaxation while establishing readout flexibility. It will facilitate multi-contrast 3D image acquisition that reveals both structural and chemical properties for extended cardiac muscle assessment.
14:35		503-02-006. Accelerated Motion-Robust Time-Efficient Whole-Liver Diffusion MRI with DWI PLUS-Plus (DWI++) for improved image quality Masami Yoneyama, Johannes Peeters, YASUHIRO GOTO, Daichi Murayama, TAKAYUKI SAKAI, Shuo Zhang, Michinobu Nagao, Marc Van Cauteren Philips Japan, Tokyo, Japan Impact: DWI++ enables motion-robust, time-efficient whole-liver DWI with improved diagnostic reliability and consistency, particularly for left-lobe evaluation. This advancement supports more accurate lesion detection, quantitative liver assessment, and broader clinical adoption of diffusion MRI in routine abdominal imaging workflows.
14:46		503-02-007. Dual-phase systolic and diastolic cardiac diffusion MRI using higher-order motion compensation at 300 mT/m gradient strength Maryam Afzali, Irvin Teh, Sam Coveney, Lars Mueller, Sarah Jones, May Lwin, Fabrizio Fasano, John Evans, Isaac Watson, Filip Szczepankiewicz, Derek Jones, Erica Dall’Armellina, Jurgen Schneider Cardiff University, Cardiff, United Kingdom Impact: This study demonstrates in vivo cardiac diffusion MRI of the human heart in systole and diastole using higher-order motion-compensated encoding at ultra-strong gradients. The approach advances diffusion assessment of myocardial microstructure and provides a framework for probing cardiac microdynamics.
14:57		503-02-008. Neural Controlled Differential Equation (NCDE) for IVIM Analysis in Flow Phantom and Multisite Breast Tumor Patients Dibash Basukala, Artem Mikheev, Daan Kuppens, Nima Gilani, Linda Moy, Savannah Partridge, Mami Iima, Oliver Gurney-Champion, Sunitha Thakur, Eric Sigmund Center for Advanced Imaging Innovation and Research (CAI²R), New York University Grossman School of Medicine, New York, United States of America Impact: Tissue diffusivity (D_t) and perfusion fraction (f_p) obtained from a flow phantom and heterogenous multi-site patient dataset with varying b-values protocols showed robustness and diagnostic utility using single deep neural network, supporting potential for widespread usage with further optimization.
15:08		503-02-009. Diffusion kurtosis imaging for detecting renal functional changes in glomerulonephritis: a longitudinal study JIAN LIU, Yu Wu, Daoyu Yang, Lisha Nie, Xianchun Zeng Guizhou Provincial People’s Hospital, Guizhou, China Impact: Medullary MD from DKI provides a noninvasive endpoint for early detection and serial monitoring of GN. It enables preclinical efficacy readouts and dose selection, supports stratification and treatment monitoring, and may lessen biopsy reliance as protocols are standardized across centers.
15:19		503-02-010. Cardiac diffusion tensor imaging at 0.6T using second-order motion-compensated single- and multi-shot EPI Yiming Dong, Martijn Nagtegaal, Ece Ercan, Jouke Smink, Christian Stoeck, Andrew Webb, Peter Börnert, Matthias van Osch, Sebastian Kozerke C.J. Gorter MRI Center, Leiden University Medical Center, Netherlands Impact: This study demonstrates the feasibility of cardiac diffusion tensor imaging at 0.6T using motion-compensated single- and multi-shot EPI. The results highlight mid-field MRI as a promising, distortion-minimized platform for motion-robust myocardial microstructure imaging in broader and potentially decentralized clinical settings.