Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition • 09-14 May 2026

Digital Poster

Body Diffusion MRI Methods

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Body Diffusion MRI Methods
Digital Poster
Diffusion
Monday, 11 May 2026
Digital Posters Row F
13:50 - 14:45
Session Number: 365-03
No CME/CE Credit
This session highlights innovative methods in improving data acquisition and reconstruction for diffusion-based microstructure measurements in a range of body applications such as tumours, muscle, kidney, heart, liver and more.

  Figure 365-03-001.  Perfusion fraction mapping in the prostate with state-of-the-art intravoxel incoherent motion (IVIM) MRI
Malwina Molendowska, Ivan Rashid, Kieran Foley, Lars Mueller, Lars Olsson, Patrik Brynolfsson, Filip Szczepankiewicz
Lund University, Lund, Sweden
Impact: Our state-of-the-art velocity-compensated IVIM exposes that conventional prostate IVIM yields biases in diffusivity and perfusion fraction. This warrants the consideration of velocity-compensation for reliable IVIM experiments, pending further validation.
  Figure 365-03-002.  A Deep learning-based Spectral Analysis of Multi-Exponential Intravoxel Incoherent Motion (D-SAME-IVIM) MRI of the Kidney
Julia Stabinska, Thomas Thiel, Alexandra Ljimani, Hans-Joerg Wittsack, Helge Zöllner
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States of America
Impact: A robust and fast method for spectral diffusion analysis capable of detecting pathophysiological changes in the kidney from multi-b-value DWI data.
  Figure 365-03-003.  Deep learning reconstruction for accelerated and quality-preserving liver IVIM protocols
Anna Casellato, Alessandra Bertoldo, Marco Castellaro, Giovanni Morana, Laura Alabiso, Angiola Saccomanno, Robert Grimm, Omar Darwish, Giovanna Nordio, Davide Piccini
University of Padova, Padova, Italy
Impact: The use of deep learning-based image reconstruction on IVIM-DWI liver imaging allows accelerating the acquisition while simultaneously preserving image quality and improving the reliability of IVIM parameter estimation, potentially offering a faster framework for non-contrast liver imaging.
  Figure 365-03-004.  Image Quality in Breast DWI Using DL readout-segmented EPI: A Comparison with Standard readout-segmented EPI at 3T
Zoia Laraib, Marialena Tsarouchi, Carla Sitges, Antonio Portaluri, Gregor Thoermer, Marnix Maas, Elisabeth Weiland, Wei Liu, Ritse Mann
Radboud University Medical Center, Nijmegen, Netherlands
Impact: DL rs-EPI improves diffusion image quality and lesion visibility without affecting maintaining similar ADC values. Its shorter acquisition time and comparable performance supports clinical implementation for faster, more robust breast MRI in the clinical practice.
  Figure 365-03-005.  Optimization of Respiratory Synchronization for Abdominal Intravoxel Incoherent Motion MRI in the Renal Medulla
Chinatsu Yamakawa, Shingo Nito, atsushi kondo, Saki Tsuchihashi, Keita Nagawa, Iichiro Osawa, Masami Yoneyama, Kaiji Inoue, Eito Kozawa
Dept.of Central Radiological Technology, Saitama Medical University Hospital, Saitama, Japan
Impact: This study provides practical guidance for optimizing abdominal intravoxel incoherent motion acquisition. Trigger and track synchronization and a 3-beat repetition time can improve the accuracy and reproducibility of perfusion and diffusion parameters in the renal medulla, enhancing diagnostic reliability.
  Figure 365-03-006.  Hybrid Diffusion of Cervical-Thoracic Pediatric Spinal Cord: Normative Analysis of NODDI, DKI, and DTI Metrics
Zahra Sadeghi Adl, Devon Middleton, Laura Krisa, Sara Naghizadehkashani, Mahdi Alizadeh, Slimane Tounekti, Scott Faro, Adam Flanders, Julien Cohen-Adad, Feroze Mohamed
Jefferson Integrated Magnetic Resonance Imaging Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Impact: First pediatric, tissue-specific diffusion reference curves (DTI, DKI, NODDI) across C1-T12 enable z-score outlier detection and age-adjusted interpretation. They provide effect-size anchors for normal development and a baseline for clinical and research uses, including pediatric SCI, transverse myelitis, and myelopathy.
  Figure 365-03-007.  Evaluation of generalist, on-the-scanner, deep learning recon for M2SE cardiac DTI
Daniel Atkinson, Peter Gatehouse, Vanessa Ferreira, Elizabeth Tunnicliffe, Rebecca Mills, Betty Raman, Patricia Lan, Haonan Wang, Xinzeng Wang, Stephen Jermy, James Grist, Damian Tyler, Margarita Gorodezky, Stefan Piechnik
Oxford Centre for Clinical MR Research (OCMR), University of Oxford, Oxford, United Kingdom
Impact: Generalist, on-the-scanner, deep learning recon appears to achieve comparable to non-deep learning cardiac diffusion tensor imaging (DTI) results with a reduced scan time. This may improve feasibility of cardiac DTI on clinical scanners where time is short.
  Figure 365-03-008.  Two-Step Fitting Enables Improved Precision of Simultaneous IVIM and Compartmental R2 Quantification
Gregory Simchick, Diego Hernando
University of Wisconsin - Madison, Madison, United States of America
Impact: Two- versus one-step fitting improved the noise performance and test-retest repeatability of the perfusion signal fraction and R2 of blood when performing simultaneous IVIM and compartmental R2 quantification. The improved repeatability may enhance clinical diagnostic value and enable treatment monitoring.
  Figure 365-03-009.  Comparison of Conventional and Deep Neural Network IVIM Fitting Strategies for Soft-Tissue Tumor Characterization
Julia Augusta de Souza Buratti, Huseyin Ekin Ergi, Ahmet Peker, Guangyu Dan, Albert Yen, Yusuf Oner, Xiaohong Joe Zhou, Muge Karaman
University of Illinois Chicago, Chicago, United States of America
Impact: This study demonstrates that DNN–based IVIM fitting achieves reproducible diffusion parameters and comparable diagnostic performance to IVIM segmented nonlinear least squares fitting, while reducing parameter variability. These findings may promote clinical translation of IVIM for reliable soft-tissue tumor characterization.
  Figure 365-03-010.  Decoding Tumor and Muscle Microstructure in HNC via Simplified IVIM MRI
Kai-Lun Cheng, Hsueh-Ju Lu, Chao-Yu Shen, Hui-Yu Wang, Ying-Hsiang Chou, Yeu-Sheng Tyan, Ping-Huei Tsai
Chung Shan Medical University Hospital, Taichung, Taiwan
Impact: This study demonstrates the potential of simplified IVIM MRI to evaluate both macrostructural and microstructural changes in the masseter muscle of HNC patients, providing valuable insights into altered tumor microenvironments and cancer-related muscle inflammation for improved prognosis prediction.
  Figure 365-03-011.  Enhanced Intravoxel Incoherent Motion three-compartmental modeling using fusion neural network
Nhat Hoang, Abrar Faiyaz, Emmanuel Mensah, Md Nasir Uddin, Jianhui Zhong, Giovanni Schifitto
University of Rochester, Rochester, United States of America
Impact: We propose a fusion network for Intravoxel Incoherent Motion (IVIM) modeling that leverages T1-weighted and FLAIR anatomical priors to improve estimation of tissue diffusion and perfusion characteristics.
  Figure 365-03-012.  Highly Efficient Cardiac Diffusion Tensor Imaging Using Interleaved Simultaneous Multi-Slice Motion-Compensated Spin-Echo
Ke Wen, Eun Ji Lim, Yaqing Luo, Pedro Ferreira, Alberto di Biase, Dudley Pennell, Andrew Scott, Sonia Nielles-Vallespin
Imperial College London, London, United Kingdom
Impact: The proposed interleaved simultaneous multi-slice flip-back motion-compensated spin-echo significantly improves the efficiency of cDTI acquisitions, enabling whole-heart coverage within 20-30 minutes while maintaining image quality, paving the way for whole-heart cDTI as an add-on to clinical exams.
  Figure 365-03-013.  AI-THiNR: A Modular AI Toolbox for Quantitative Multicontrast MRI of Head and Neck Tumors
Muhammad Awais, Ramesh Paudyal, Akash Shah, Vaios Hatzoglou, Nora Katabi, Eve LoCastro, Richard Wong, Ashok Shaha, R. M. Tuttle, Nadeem Riaz, Nancy Lee, Lawrence Schwartz, Amita Shukla-Dave
Memorial Sloan Kettering Cancer Center, New York, United States of America
Impact: AI-THiNR is a comprehensive AI toolbox for multicontrast MRI analysis. It integrates convolutional neural network (CNN)-based deep feature extraction and physics-based diffusion modeling, enabling tumor characterization, improved diagnostic precision, and scalable clinical translation in head-and-neck oncology.
  Figure 365-03-014.  Gender and Age Effects on Lumbar Paraspinal Muscles: A Multimodal MRI Study Correlating DTI, PDFF and Muscle Strength
bo hu, Dandan Zheng, ling wang, xiaoguang cheng
beijing jishuitan hospital, capital medical university, Beijing, China
Impact: This study provides novel insights into paraspinal muscle degeneration, demonstrating multimodal MRI's capability to detect microstructural changes predictive of functional decline, potentially enabling early intervention for age-related spinal disorders.
  Figure 365-03-015.  Definition of a liver function index using intra-voxel incoherent motion modelling for function-guided liver cancer radiation
Fidel Navarro Salazar, Yu Sun, Tim Wang, Sheryl Foster, Naeim Sanaei, Jonathan Sykes, Annette Haworth, Sirisha Tadimalla
The University of Sydney, Sydney, Australia
Impact: This study introduces a liver functional index to generate voxel-wise liver function maps, enabling functional-avoidance radiation therapy for patients with HCC and impaired liver function.

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