Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition - From Diffusion Characteristics Toward Clinical Impact

From Diffusion Characteristics Toward Clinical Impact

Oral

Diffusion

Tuesday, 12 May 2026

Ballroom West

16:00 - 17:50

Moderators: Jennifer McNab & Oscar Jalnefjord

Session Number: 405-04

No CME/CE Credit

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This session highlights recent methodological and translational advances in diffusion MRI. Presentations span foundational developments in DWI/DTI/DKI and diffusion modeling, as well as applications in white matter characterization for neurological and psychiatric disorders and in oncologic imaging. Particular attention is given to challenges that limit clinical deployment, such as inter-site variability and MRI harmonization, as well as to emerging solutions that improve robustness, interpretability, and reproducibility. By integrating technical innovation with disease-focused applications, this session aims to bridge diffusion MRI methodology and real-world clinical decision-making.

Skill Level: Intermediate

16:00		405-04-001. Introduction Oscar Jalnefjord University of Gothenburg, Gothenburg, Sweden
16:11		405-04-002. Characterization and longitudinal assessment of myocardial microstructure in ICI myocarditis using ultra-high-gradient cDTI Xianling Qian, Ling Chen, Zhuolin Liu, Jili Chen, Christopher Nguyen, Caixia Fu, xiaoming Liu, Yuchi Liu, Yishi Wang, Yunzhu Wu, Jing An, Danielle Kara, Dingheng Mai, Moses Cook, Zachary Player, Xuhao Song, Yinyin Chen, Hang Jin, Mengsu Zeng Zhongshan Hospital, Fudan University, Shanghai, China Impact: Free-breathing cardiac diffusion tensor imaging enables contrast-free detection and monitoring of microstructural injury in immune checkpoint inhibitor-related myocarditis, providing a robust imaging biomarker that complements guideline-recommended T1/T2 criteria and may improve early diagnosis, risk stratification, and therapeutic monitoring.
16:22		405-04-003. Signatures of structural disorder in axons and glial processes in human white matter using time-dependent diffusion MRS Jessie Mosso, Santiago Coelho, Ricardo Coronado-Leija, Valentin Stepanov, Andrè Döring, Roland Kreis, Els Fieremans, Dmitry Novikov New York University Grossman School of Medicine, New York, United States of America Impact: Diffusion-tensor MRS uncovers time-dependence of diffusion coefficient for axon- and glia-specific metabolites in human white matter. The derived axon geometry parameters agree for NAA and water, and differ for choline, suggesting that glial processes are microstructurally distinct from axons.
16:33		405-04-004. Characterizing the diffusion properties of prostate epithelium across Gleason grades using MR microscopy Adam Phipps, Nyoman Kurniawan, Geoffrey Watson, Paul Sved, Samson Dowland, Marta Masramon, Eleftheria Panagiotaki, David Atkinson , Roger Bourne University College London, London, United Kingdom Impact: Characterizing the diffusion properties of prostate epithelium across Gleason grades will help to assess the potential for non-invasive prostate cancer grading using quantitative dMRI.
16:44		405-04-005. Evaluation of Stimulated Echo Diffusion Weighted Imaging in Patients with Suspected Prostate Cancer Srijyotsna Volety, Felix Schön, Ali Pirasteh, Diego Hernando University of Wisconsin - Madison, Madison, United States of America Impact: Stimulated-echo DWI acquired with an intermediate b-value (b = 1000 s/mm²) demonstrated high SNR, lesion contrast, and reliable ADC mapping for evaluation of prostate lesions.
16:55		405-04-006. Shared and specific submillimeter cortical radial diffusion changes in schizophrenia and bipolar disorder Xing Li, Jiaxin Zeng, Naici Liu, Huilou Liang, Wenjing Zhang, Su Lui West China Hospital of Sichuan University, Chendu, China Impact: This study reveals shared and specific submillimeter radial diffusion parameter alterations in schizophrenia and bipolar disorder, highlighting macroscopic gray matter diffusion changes and providing new insights into the neurobiological underpinnings and psychopathological mechanisms of these major mental disorders.
17:06		405-04-007. Privacy-Preserving Multi-Site Diffusion MRI Harmonization via Federated Learning Wei Zhang, Yijie Li, Xi Zhu, Chengjin Li, Lipeng Ning, Yogesh Rathi, Lauren O’Donnell, Fan Zhang University of Electronic Science and Technology of China, Chengdu, China Impact: This study introduces a novel federated style-transfer learning framework for multi-site diffusion MRI harmonization. It preserves data privacy, requires no traveling subjects, and enables flexible harmonization across multiple sites for large-scale data analysis.
17:17		405-04-008. Towards high-performance breast diffusion MRI: evaluation of temperature, nerve stimulation, and diffusion measurements with Gerrit Arends, Edwin Versteeg, Feng Jia, Dennis Klomp, Maxim Zaitsev, Sebastian Littin, Chantal Tax University Medical Center Utrecht, Utrecht, Netherlands Impact: This work demonstrates feasibility of diffusion MRI with a dedicated breast gradient insert, validating safety, temperature, and PNS performance. Results on this prototype enable development of a high-performance breast gradient which could improve breast cancer characterization with diffusion MRI.
17:28		405-04-009. Predictive Value of MR Cytometry at Different Diffusion Times for pCR in Breast Cancer After Neoadjuvant Chemotherapy JIE DING, Diwei Shi, Chao You, Junzhong Xu, Caixia Fu, Xiuzheng Yue, Hua Guo, Yajia Gu Medical Imaging Center, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China Impact: Temporal diffusion spectroscopy provides microstructure-sensitive biomarkers that improve pCR prediction over ADC and RECIST within each protocol, with highest discrimination at short diffusion times. Findings support biopsy-sparing stratification, therapy adaptation, and model-specific use of TDS in management of breast cancer.